Search
Results: 455
Prevalence and predictors of hospital prealerting in acute stroke
JP Sheppard, A Lindenmeyer, RM Mellor, S Greenfield, J Mant, T Quinn, A Rosser, D Sandler, D Sims, M Ward, RJ McManus, CLAHRC BBC investigators
May 02, 2018
BACKGROUND: Thrombolysis can significantly reduce the burden of stroke but the time window for safe and effective treatment is short. In patients travelling to hospital via ambulance, the sending of a 'prealert' message can...
The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls
BACKGROUND: Modern cognitive neuropsychological models of depression posit that negatively biased emotional ("hot") processing confers risk for depression, while preserved executive function ("cold") cognition promotes...
Prevalence and costs of treating uncomplicated stage 1 hypertension in primary care
Antihypertensive Agents cardiovascular disease risk Guidelines Primary Prevention Adult Aged Antihypertensive Agents Cardiovascular Diseases Cost-Benefit Analysis Cross-Sectional Studies England Female General Practice Humans Hypertension Male Middle Aged Practice Guidelines as Topic prevalence Primary Health Care Primary Prevention
Chiral soliton predictions for exotic baryons.
We re-analyze the predictions of chiral-soliton models for the masses and
decay widths of baryons in the exotic antidecuplet of flavour SU(3). The calculated
ranges of the chiral-soliton moment of inertia and the π-nucleon...
Published by: HEP, Cavendish Laboratory, University of Cambridge
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta.
Alzheimer’s disease IL1β LIPOPOLYSACCHARIDE Microglia Organotypic hippocampal slice culture Presynaptic synapse Synaptophysin Animals Brain Inflammation Inflammation Mediators Interleukin-1beta Lipopolysaccharides Mice Mice Inbred C57BL Microglia Organ Culture Techniques Presynaptic Terminals Synapses
Missed opportunities in prevention of cardiovascular disease in primary care
Antihypertensive Agents Primary Health Care Primary Prevention risk Secondary Prevention Statins Adult Aged Antihypertensive Agents Cardiovascular Diseases Cross-Sectional Studies Early Diagnosis Female General Practice Guideline Adherence Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Practice Guidelines as Topic Primary Prevention Retrospective Studies Risk Assessment United Kingdom Young Adult
Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.
Amyloid beta peptides (Aβ) proteins play a key role in vascular pathology in Alzheimer's Disease (AD) including impairment of the blood-brain barrier and aberrant angiogenesis. Although previous work has demonstrated a...
Published by: Cell Death & Disease
Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections.
Bethany L Dearlove, Alison J Cody, Ben Pascoe, Guillaume Méric, Daniel J Wilson, Samuel K Sheppard
Jul 24, 2015
Association of guideline and policy changes with incidence of lifestyle advice and treatment for uncomplicated mild hypertension in primary care
James P Sheppard, Sarah Stevens, Richard J Stevens, Jonathan Mant, Una Martin, FD Richard Hobbs, Richard J McManus
Nov 07, 2018
OBJECTIVES: Evidence to support initiation of pharmacological treatment in patients with uncomplicated (low risk) mild hypertension is inconclusive. As such, clinical guidelines are contradictory and healthcare policy has...
blood pressure Cardiovascular disease prevention Electronic Health Records General Practice interrupted time series Adult Antihypertensive Agents blood pressure Directive Counseling Electronic Health Records England Female Health Policy Humans Hypertension Interrupted Time Series Analysis Life Style Longitudinal Studies Male Medical Record Linkage Middle Aged Practice Guidelines as Topic Primary Health Care Quality of Health Care
Genome-wide identification of host-segregating SNPs for source attribution of clinical Campylobacter coli isolates
Quentin Jehanne, Ben Pascoe, Lucie Bénéjat, Astrid Ducournau, Alice Buissonnière, Evangelos Mourkas, Francis Mégraud, Emilie Bessède, Samuel K Sheppard, Philippe Lehours
Dec 31, 2020
Campylobacter is among the most common causes of gastroenteritis worldwide. Campylobacter jejuni and Campylobacter coli are the most common species causing human-disease. DNA-sequence-based methods for strain characterization...
Impact of Changes to National Hypertension Guidelines on Hypertension Management and Outcomes in the United Kingdom.
Sarah L Lay-Flurrie, James P Sheppard, Richard J Stevens, Christian Mallen, Carl Heneghan, FD Richard Hobbs, Bryan Williams, Jonathan Mant, Richard J McManus
Feb 10, 2020
In recent years, national and international guidelines have recommended the use of out-of-office blood pressure monitoring for diagnosing hypertension. Despite evidence of cost-effectiveness, critics expressed concerns this...
Published by: Hypertension
A comparative genomics study of <i>Staphylococcus epidermidis</i> from orthopedic device-related infections correlated with patient outcome
Virginia Post, Llinos G Harris, Mario Morgenstern, Leonardos Mageiros, Matthew D. Hitchings, Guillaume Méric, Ben Pascoe, Samuel K Sheppard, R Geoff Richards, T Fintan Moriarty
Oct 01, 2017
Staphylococcus epidermidis has emerged as an important opportunistic pathogen causing orthopedic device-related infections (ODRIs). This study investigated the association of genome variation and phenotypic features of the...
Genome-wide identification of host-segregating epidemiological markers for source attribution in <i>Campylobacter jejuni</i>
Amandine Thépault, Guillaume Méric, Katell Rivoal, Ben Pascoe, Leonardos Mageiros, Fabrice Touzain, Valérie Rose, Véronique Béven, Marianne Chemaly, Samuel K Sheppard
Apr 01, 2017
Campylobacter is among the most common worldwide causes of bacterial gastroenteritis. This organism is part of the commensal microbiota of numerous host species, including livestock, and these animals constitute potential...
|
|< |
< |
1 |