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CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease
Chemically Aware Model Builder (camb)
Daniel S Murrell, Isidro Cortes-Ciriano, Gerard JP van Westen, Ian P Stott, Andreas Bender, Thérèse E Malliavin, Robert C Glen
Apr 26, 2018
BACKGROUND: In silico predictive models have proved to be valuable for the optimisation of compound potency, selectivity and safety profiles in the drug discovery process. RESULTS: camb is an R package that provides an...
The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls
BACKGROUND: Modern cognitive neuropsychological models of depression posit that negatively biased emotional ("hot") processing confers risk for depression, while preserved executive function ("cold") cognition promotes...
Disordered domains in chromatin-binding proteins.
Chromatin comprises proteins, DNA and RNA, and its function is to condense and package the genome in a way that allows the necessary transactions such as transcription, replication and repair to occur in a highly organised and...
SDSS-IV MaNGA
E Cheung, DV Stark, S Huang, KHR Rubin, L Lin, C Tremonti, K Zhang, R Yan, D Bizyaev, M Boquien, JR Brownstein, N Drory, JD Gelfand, JH Knapen, R Maiolino, O Malanushenko, KL Masters, MR Merrifield, Z Pace, K Pan, RA Riffel, A Roman-Lopes, W Rujopakarn, DP Schneider, JP Stott, D Thomas, A-M Weijmans
Dec 21, 2016
Hyperosmotic stress induces cell-dependent aggregation of α-synuclein.
Alexandra MC Fragniere, Simon RW Stott, Shaline V Fazal, Maria Andreasen, Kirsten Scott, Roger A Barker
Jan 17, 2019
Chiral soliton predictions for exotic baryons.
We re-analyze the predictions of chiral-soliton models for the masses and
decay widths of baryons in the exotic antidecuplet of flavour SU(3). The calculated
ranges of the chiral-soliton moment of inertia and the π-nucleon...
Published by: HEP, Cavendish Laboratory, University of Cambridge
Characterization of the interaction between HMGB1 and H3-a possible means of positioning HMGB1 in chromatin.
High mobility group protein B1 (HMGB1) binds to the internucleosomal linker DNA in chromatin and abuts the nucleosome. Bending and untwisting of the linker DNA results in transmission of strain to the nucleosome core, disrupting...
Underpotential surface reduction of mesoporous CeO 2 nanoparticle films
Charles Y. Cummings, Susan J. Stott, Michael J. Bonné, Karen J. Edler, Pauline M. King, Roger J. Mortimer, Frank Marken
Dec 01, 2008
The formation of variable-thickness CeO 2 nanoparticle mesoporous films from a colloidal nanoparticle solution (approximately 1-3-nm-diameter CeO 2) is demonstrated using a layer-by-layer deposition...
assembly CeO Cyclic voltammetry Electroanalysis Electrocatalysis ITO nanoparticle sensor Underpotential reduction /dk/atira/pure/subjectarea/asjc/1600/1603 name=Electrochemistry /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science
Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.
Ruma Raha-Chowdhury, Animesh Alexander Raha, Serhiy Forostyak, Jing-Wei Zhao, Simon Russell William Stott, Adrian Bomford
Sep 29, 2016
BACKGROUND: Hepcidin is a peptide hormone belonging to the defensin family of cationic antimicrobial molecules that has an essential role in systemic iron homeostasis. The peptide is synthesised by hepatocytes and transported in...
Characterization of chromoshadow domain-mediated binding of heterochromatin protein 1α (HP1α) to histone H3.
Alexandria N Richart, Clair IW Brunner, Katherine Stott, Natalia V Murzina, Jean O Thomas
Dec 03, 2020
The chromoshadow domain (CSD) of heterochromatin protein 1 (HP1) was recently shown to contribute to chromatin binding and transcriptional regulation through interaction with histone H3. Here, we demonstrate the structural basis...
Convocation for the Conferring of Degrees, 1961
The Rockefeller University
Jan 01, 0001
Convocation for the Conferring of Degrees. 16 June 1961
The addresses printed here were given by members of the faculty in presenting candidates for the degree of Doctor of Philosophy, and by President Bronk in citing Thomas...
Published by: The Rockefeller Institute Press
Changing trends in the management of intertrochanteric hip fractures - a single centre experience
Piers R. J. Page, Roxana Lord, Ahsin Jawad, Edward Dawe, Philip Stott, Benedict Rogers, Richie Gill
Jul 01, 2016
With an annual incidence greater than 65,000 in the United
Kingdom, hip fractures are a common but debilitating injury predominantly
affecting those over 65. Treatment is based on the anatomical location of
the...
Kingdom, hip fractures are a common but debilitating injury predominantly
affecting those over 65. Treatment is based on the anatomical location of
the...
Highly disordered histone H1-DNA model complexes and their condensates.
Abigail L Turner, Matthew Watson, Oscar G Wilkins, Laura Cato, Andrew Travers, Jean O Thomas, Katherine Stott
Nov 21, 2018
Disordered proteins play an essential role in a wide variety of biological processes, and are often posttranslationally modified. One such protein is histone H1; its highly disordered C-terminal tail (CH1) condenses...
Chromatin histone H1 intrinsic disorder phase separation Phosphorylation Animals Chromatin Chromatin Assembly and Disassembly DNA DNA-Binding Proteins Histones Humans Magnetic Resonance Spectroscopy Nucleic Acid Conformation Phosphorylation Protein Binding Protein Conformation Protein Processing Post-Translational
Bounds on the dynamics of sink populations with noisy immigration
Eric Alan Eager, Chris Guiver, Dave Hodgson, Richard Rebarber, Iain Stott, Stuart Townley
Mar 01, 2014
Sink populations are doomed to decline to extinction in the absence of immigration. The dynamics of sink populations are not easily modelled using the standard framework of per capita rates of immigration, because numbers of...
Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α.
CK2α is a ubiquitous, well-studied kinase that is a target for small-molecule inhibition, for treatment of cancers. While many different classes of adenosine 5'-triphosphate (ATP)-competitive inhibitors have been described for...
Adenosine Triphosphate Allosteric Regulation Allosteric Site Binding Competitive Casein Kinase II Crystallography X-Ray Deuterium Exchange Measurement Humans Ligands Molecular Dynamics Simulation Naphthyridines Nuclear Magnetic Resonance Biomolecular Phenazines Protein Binding Protein Kinase Inhibitors Recombinant Proteins
Characterisation of FUT4 and FUT6 α-(1 → 2)-fucosyltransferases reveals that absence of root arabinogalactan fucosylation increases Arabidopsis root growth salt sensitivity.
Theodora Tryfona, Tina E Theys, Tanya Wagner, Katherine Stott, Kenneth Keegstra, Paul Dupree
Jan 16, 2018
Plant type II arabinogalactan (AG) polysaccharides are attached to arabinogalactan proteins (AGPs) at hydroxyproline residues, and they are very diverse and heterogeneous structures. The AG consists of a β-(1 → 3)-linked...
The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination.
Bahja Al-Riyami, Fatma Işık Üstok, Katherine Stott, Dimitri Y Chirgadze, Graham Christie
Sep 16, 2016
GH25 family cortex lytic enzyme peptidoglycan lysin spore Bacterial Proteins Catalytic Domain Cloning Molecular Clostridium perfringens Crystallography X-Ray Escherichia coli Fibronectin Type III Domain Gene Expression Hydrolysis Models Molecular Muramidase Peptidoglycan Protein Multimerization Protein Structure Secondary Recombinant Proteins Spores Bacterial
Underpotential surface reduction of mesoporous CeO 2 nanoparticle films
Charles Y. Cummings, Susan J. Stott, Michael J. Bonné, Karen J. Edler, Pauline M. King, Roger J. Mortimer, Frank Marken
Dec 01, 2008
The formation of variable-thickness CeO 2 nanoparticle mesoporous films from a colloidal nanoparticle solution (approximately 1-3-nm-diameter CeO 2) is demonstrated using a layer-by-layer deposition...
assembly CeO Cyclic voltammetry Electroanalysis Electrocatalysis ITO nanoparticle sensor Underpotential reduction /dk/atira/pure/subjectarea/asjc/1600/1603 name=Electrochemistry /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science
Development of an oligosaccharide library to characterise the structural variation in glucuronoarabinoxylan in the cell walls of vegetative tissues in grasses.
Theodora Tryfona, Mathias Sorieul, Carolina Feijao, Katherine Stott, Denis V Rubtsov, Nadine Anders, Paul Dupree
Apr 29, 2019
BACKGROUND: Grass glucuronoarabinoxylan (GAX) substitutions can inhibit enzymatic degradation and are involved in the interaction of xylan with cell wall cellulose and lignin, factors which contribute to the recalcitrance of...
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