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Newcastle disease virus expressing a dendritic cell-targeted HIV Gag protein induces a potent Gag-specific immune response in mice
Viral vaccine vectors have emerged as an attractive strategy for the development of a human immunodeficiency virus (HIV) vaccine. Recombinant Newcastle disease virus (rNDV) stands out as a vaccine vector since it has a proven...
Published by: Rockefeller University
The spectrum of STAT functions in mammary gland development.
The signal transducer and activator of transcription (STAT) family of transcription factors have a spectrum of functions in mammary gland development. In some cases these roles parallel those of STATs in other organ systems...
Sinus-like dilatations of the mammary milk ducts, Ki67 expression, and CD3-positive T lymphocyte infiltration, in the mammary gland of wild European rabbits during pregnancy and lactation.
Sinus-like dilatations of the mammary duct are recognisable in the mammary gland of pregnant and lactating wild European rabbits. These dilatations exhibit a bilaminar epithelial lining, with luminal epithelial cells expressing...
Mammary gland development from a single cell 'omics view.
Understanding the complexity and heterogeneity of mammary cell subpopulations is vital to delineate the mechanisms behind breast cancer development, progression and prevention. Increasingly sophisticated tools for investigating...
Development and Pathology of the Equine Mammary Gland
Katherine Hughes
Jun 26, 2021
Abstract: An understanding of the anatomy, histology, and development of the equine mammary gland underpins study of the pathology of diseases including galactorrhoea, agalactia, mastitis, and mammary tumour development. This...
Dynamic architectural interplay between leucocytes and mammary epithelial cells.
The adult mammary gland undergoes dynamic changes during puberty and the postnatal developmental cycle. The mammary epithelium is composed of a bilayer of outer basal, or myoepithelial, cells and inner luminal cells, the latter...
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer.
Marine Inglebert, Martina Dettwiler, Kerstin Hahn, Anna Letko, Cord Drogemuller, John Doench, Adam Brown, Yasin Memari, Helen R Davies, Andrea Degasperi, Serena Nik-Zainal, Sven Rottenberg
Oct 27, 2022
Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features, hormone receptor expression...
Developmental Stage-Specific Distribution of Macrophages in Mouse Mammary Gland.
Mammary gland development begins in the embryo and continues throughout the reproductive life of female mammals. Tissue macrophages (Mϕs), dependent on signals from the Mϕ colony stimulating factor 1 receptor (CSF1R), have been...
Thirteenth Annual ENBDC Workshop
The thirteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) Laboratories Annual Workshop took place on the 28-30 April 2022 in Weggis, Switzerland and focused on methods in mammary gland...
Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB.
Holly Holliday, Daniel Roden, Simon Junankar, Sunny Z Wu, Laura A Baker, Christoph Krisp, Chia-Ling Chan, Andrea McFarland, Joanna N Skhinas, Thomas R Cox, Bhupinder Pal, Nicholas D Huntington, Christopher J Ormandy, Jason S Carroll, Jane Visvader, Mark P Molloy, Alexander Swarbrick
Jan 28, 2021
Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem...
A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland.
BACKGROUND: This paper describes the derivation and characterization of a novel, conditionally immortal mammary epithelial cell line named KIM-2. These cells were derived from mid-pregnant mammary glands of a mouse harbouring...
Animals Antigens Viral Tumor Apoptosis Biomarkers Breast Caseins Cell Culture Techniques Cell Differentiation Cell Line Transformed Epithelium Female Gene Dosage Genetic Vectors Lactoglobulins Mice Mice Transgenic Milk Proteins Pregnancy Promoter Regions Genetic Recombinant Proteins Signal Transduction Simian virus 40 Transcriptional Activation
The Eleventh ENBDC Workshop
Vida Vafaizadeh, Emilia Peuhu, Marja L Mikkola, Walid T Khaled, Mohamed Bentires-Alj, Zuzana Koledova
Oct 29, 2019
The eleventh annual workshop of the European Network for Breast Development and Cancer, Methods in mammary gland biology and breast cancer, took place on the 16th to 18th of May 2019 in Weggis, Switzerland. The main topics of...
Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing.
Karsten Bach, Sara Pensa, Marta Grzelak, James Hadfield, David J Adams, John C Marioni, Walid T Khaled
Jun 08, 2018
Characterising the hierarchy of mammary epithelial cells (MECs) and how they are regulated during adult development is important for understanding how breast cancer arises. Here we report the use of single-cell RNA sequencing to...
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer.
Marine Inglebert, Martina Dettwiler, Kerstin Hahn, Anna Letko, Cord Drogemuller, John Doench, Adam Brown, Yasin Memari, Helen R Davies, Andrea Degasperi, Serena Nik-Zainal, Sven Rottenberg
Nov 27, 2022
Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features, hormone receptor expression...
Alveolar cells in the mammary gland
Christine J Watson
Jun 13, 2022
The mammary gland provides a spectacular example of physiological cell death whereby the cells that produce milk during lactation are removed swiftly, efficiently, and without inducing inflammation upon the cessation of...
Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
Anna D Staniszewska, Sara Pensa, Maria M Caffarel, Lisa H Anderson, Valeria Poli, Christine J Watson
Mar 18, 2021
Stat3 has a defined role in mammary gland where it is a critical mediator of cell death during post-lactational regression. On the other hand, Stat3 is required for the self-renewal of embryonic stem cells and is sufficient for...
The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer.
Since seminal descriptions of signal transducer and activator of transcription 3 (STAT3) as a signal transducer and transcriptional regulator, which is most usually activated by phosphorylation of a specific tyrosine residue, a...
4T1 CLCA STAT3 Breast Cancer chitinase 3-like 1 cow involution lysosome mammary gland microenvironment Animals Biomarkers Breast Neoplasms Cell Transformation Neoplastic Cellular Microenvironment Female Gene Expression Regulation Humans Mammary Glands Human STAT3 Transcription Factor Signal Transduction
The Mammary Microenvironment in Mastitis in Humans, Dairy Ruminants, Rabbits and Rodents
The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition...
Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression.
INTRODUCTION: In order to gain a better understanding of the molecular processes that underlie apoptosis and tissue regression in mammary gland, we undertook a large-scale analysis of transcriptional changes during the mouse...
Acute-Phase Reaction Animals Apoptosis Cytokines DNA-Binding Proteins Female Gene Expression Profiling Gene Expression Regulation Genes Immunity Innate Lactation Mammary Glands Animal Mice Mice Inbred C57BL Oligonucleotide Array Sequence Analysis Pregnancy Receptors Tumor Necrosis Factor STAT3 Transcription Factor Time Factors Trans-Activators Weaning
MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene.
Yu Wei Phua, Akira Nguyen, Daniel L Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea McFarland, Roslin Russell, Warren Kaplan, Mark J Cowley, Radhika Nair, Elena Zotenko, Sandra O'Toole, Shi-Xiong Tan, David E James, Susan J Clark, Hosein Kouros-Mehr, Alexander Swarbrick
May 07, 2019
INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary...
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Cell Transformation Neoplastic Cluster Analysis Epigenesis Genetic Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing Genes Tumor Suppressor Humans Mammary Glands Animal Mice MicroRNAs Neoplasm Metastasis Prognosis Proto-Oncogene Proteins c-akt RNA Interference Sexual Maturation TOR Serine-Threonine Kinases
Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk
Abstract Under normal conditions, the most significant expansion and differentiation of the adult mammary gland occurs in response to systemic reproductive hormones during pregnancy and lactation...
Alecia-Jane Twigger, Lisa K Engelbrecht, Karsten Bach, Isabel Schultz-Pernice, Sara Pensa, Jack Stenning, Stefania Petricca, Christina H Scheel, Walid T Khaled
Jan 28, 2022
The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours
Loreta M Rodrigues, Santiago Uribe-Lewis, Basetti Madhu, Davina J Honess, Marion Stubbs, John R Griffiths
May 05, 2017
Abstract
Background
Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases;...
Disruptive Innovation in the Middle Eastern FinTech Sector
Building on prior suggestions concerning corporate resources as causes of disruptive innovation for increasing competitive advantage in developed economies, this research empirically re-investigated such assumptions in emerging...
Published by: IGI Global Scientific Publishing
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
Daniel G Holland, Angela Burleigh, Anna Git, Mae A Goldgraben, Pedro A Perez-Mancera, Suet-Feung Chin, Antonio Hurtado, Alejandra Bruna, H Raza Ali, Wendy Greenwood, Mark J Dunning, Shamith Samarajiwa, Suraj Menon, Oscar M Rueda, Andy G Lynch, Steven McKinney, Ian O Ellis, Connie J Eaves, Jason S Carroll, Christina Curtis, Samuel Aparicio, Carlos Caldas
Feb 17, 2021
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon...
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