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NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K. Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M. Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D’Alessio, Nicola Personeni, Lorenza Rimassa, Ann K. Daly, Bernhard Scheiner, Katharina Pomej, Martha M. Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G. Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G. Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E. Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U. Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N. Marche, Thomas Decaens, David J. Pinato, Roland Rad, Joachim C. Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M. Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M. Llovet, Mathias Heikenwalder
Apr 14, 2021
Abstract: Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based...
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.
Carmen Rubio, Marta Puerto, Juan J García-Rodríquez, Van B Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M Gribble, Frank Reimann, Luis G Guijarro, Jose M Carrascosa, Ángela M Valverde
May 05, 2020
OBJECTIVE:Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase...
Published by: Molecular metabolism
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K Daly, Bernhard Scheiner, Katharina Pomej, Martha M Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N Marche, Thomas Decaens, David J Pinato, Roland Rad, Joachim C Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M Llovet, Mathias Heikenwalder
May 05, 2021
Hepatocellular carcinoma (HCC) can have viral or non-viral causes1-5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of...
Cross-linkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis.
Carlos Patino Descovich, Daniel B Cortes, Sean Ryan, Jazmine Nash, Li Zhang, Paul S Maddox, Francois Nedelec, Amy Shaub Maddox
Jul 29, 2020
Cell shape changes such as cytokinesis are driven by the actomyosin contractile cytoskeleton. The molecular rearrangements that bring about contractility in nonmuscle cells are currently debated. Specifically, both filament...
Random-settlement arbitration and the generalized Nash solution:
We study bilateral bargaining á la Nash (Econometrica 21:128–140, 1953) but where players face two sources of uncertainty when demands are mutually incompatible. First, there is complete breakdown of negotiations with players...
Random-settlement arbitration and the generalized Nash solution:
We study bilateral bargaining á la Nash (Econometrica 21:128–140, 1953) but where players face two sources of uncertainty when demands are mutually incompatible. First, there is complete breakdown of negotiations with players...
On Distributed Scheduling of Flexible Demand and Nash Equilibria in the Electricity Market
This paper presents a novel game theory approach for large-scale deployment of price-responsive electrical appliances. In the proposed distributed control scheme, each appliance independently schedules its power consumption on...
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
Elizabeth K Speliotes, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim, Cameron D Palmer, Vilmundur Gudnason, Gudny Eiriksdottir, Melissa E Garcia, Lenore J Launer, Michael A Nalls, Jeanne M Clark, Braxton D Mitchell, Alan R Shuldiner, Johannah L Butler, Marta Tomas, Udo Hoffmann, Shih-Jen Hwang, Joseph M Massaro, Christopher J O'Donnell, Dushyant V Sahani, Veikko Salomaa, Eric E Schadt, Stephen M Schwartz, David S Siscovick, NASH CRN, GIANT Consortium, MAGIC Investigators, Benjamin F Voight, J Jeffrey Carr, Mary F Feitosa, Tamara B Harris, Caroline S Fox, Albert V Smith, WH Linda Kao, Joel N Hirschhorn, Ingrid B Borecki, GOLD Consortium
Jan 23, 2018
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide...
Adaptor Proteins Signal Transducing Adult Aged Aged 80 and over Blood Glucose Case-Control Studies Chondroitin Sulfate Proteoglycans Cohort Studies Fatty Liver Genome-Wide Association Study Humans Insulin Lectins C-Type LIPASE Male Membrane Proteins Middle Aged Mutation Missense Nerve Tissue Proteins Neurocan non-alcoholic fatty liver disease Polymorphism Single Nucleotide Quantitative Trait Loci Tomography X-Ray Computed
On Distributed Scheduling of Flexible Demand and Nash Equilibria in the Electricity Market
This paper presents a novel game theory approach for large-scale deployment of price-responsive electrical appliances. In the proposed distributed control scheme, each appliance independently schedules its power consumption on...
Dining on a Dollar: Financial Social Work and Healthy Food Options
For the working poor and other food-insecure families, with limited resources, the USDA monthly food budget recommendations are unattainable. Often families are faced with having to choose between paying household bills or...
Published by: Winthrop University
Focality and Asymmetry in Multi-battle Contests
This article examines the influence of focality in Colonel Blotto games with a lottery contest success function, where the equilibrium is unique and in pure strategies. We hypothesize that the salience of battlefields affects...
Focality and Asymmetry in Multi-battle Contests
This article examines the influence of focality in Colonel Blotto games with a lottery contest success function, where the equilibrium is unique and in pure strategies. We hypothesize that the salience of battlefields affects...
Unmet needs in pediatric NAFLD research
Pediatric nonalcoholic fatty liver disease (NAFLD) is common disorder that has complex pathophysiology and unquantified clinical significance. Though there have been major advances in the field, there is much yet to be...
Nonalcoholic fatty liver disease fatty liver disease hepatology Microbiome Pediatrics Adolescent Biomedical Research Cardiovascular Diseases Child Child Preschool Dysbiosis Gastrointestinal Microbiome Host Microbial Interactions Humans Infant Infant Newborn Metabolic Syndrome non-alcoholic fatty liver disease Risk Assessment
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.
Gretchen Wolff, Minako Sakurai, Amit Mhamane, Maria Troullinaki, Adriano Maida, Ioannis K Deligiannis, Kelvin Yin, Peter Weber, Jakob Morgenstern, Annika Wieder, Yun Kwon, Revathi Sekar, Anja Zeigerer, Michael Roden, Matthias Blüher, Nadine Volk, Tanja Poth, Thilo Hackert, Lena Wiedmann, Francesca De Angelis Rigotti, Juan Rodriguez-Vita, Andreas Fischer, Rajesh Mukthavaram, Pattraranee Limphong, Kiyoshi Tachikawa, Priya Karmali, Joseph Payne, Padmanabh Chivukula, Bilgen Ekim-Üstünel, Celia P Martinez-Jimenez, Julia Szendrödi, Peter Nawroth, Stephan Herzig
May 09, 2022
OBJECTIVE: Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic...
The Grizzly, April 23, 2009
Kristi Blust, Gabrielle Poretta, Gianna Paone, Caitlin Dalik, Lisa Jobe, Serena Mithboakar, Liz Kilmer, Roger Lee, Laurel Salvo, Zach Shamberg, Chris Capone, Christopher Schaeffer, Jonathan Edward Barber, Karin Swartz
Jan 01, 0001
Breakaway Productions Holds Annual One-Act Play Festival Red in the Face? Blushing May Indicate More Than Sheer Embarrassment Are You Contributing to Violence in Congo? Taking the Industry by Storm: Ms. Jazmine Sullivan ...
Ursinus College Collegeville Pennsylvania newspaper theater Jazmine Sullivan tennis cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Potential renewable oxygenated biofuels for the aviation and road transport sectors
Currently two major biofuels are present in the global fuel market; bioethanol which is largely produced by the fermentation of sugars or starches and biodiesel which is produced from the transesterification of vegetable oils...
The effect of microstructure on models for the flow of a Bingham fluid in porous media
The Buckingham-Reiner models for the one-dimensional flow of a Bingham fluid along a uniform pipe or channel are well-known, but are modified here to cover much more general one-dimensional configurations. These...
Potential renewable oxygenated biofuels for the aviation and road transport sectors
Currently two major biofuels are present in the global fuel market; bioethanol which is largely produced by the fermentation of sugars or starches and biodiesel which is produced from the transesterification of vegetable oils...
Biocatalytic dearomatisation of para-fluorobenzoic acid
The enzyme benzoate dioxygenase (BZDO) from Ralstonia eutropha B9 is able to dihydroxylate benzoic acids in a dearomative process that proceeds with a different regioselectivity than other known dioxygenase enzymes. Here we show...
The effect of microstructure on models for the flow of a Bingham fluid in porous media
The Buckingham-Reiner models for the one-dimensional flow of a Bingham fluid along a uniform pipe or channel are well-known, but are modified here to cover much more general one-dimensional configurations. These...
Hypoxia-Inducible Factors as Key Players in the Pathogenesis of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) and its more severe form non-alcoholic steatohepatitis (NASH) are a major public health concern with high and increasing global prevalence, and a significant disease burden owing to its...
Physiological responses to moderate intensity continuous and high-intensity interval exercise in persons with paraplegia
Study design: Randomized crossover. Objectives: To test differences in the duration and magnitude of physiological response to isocaloric moderate intensity continuous (MICE) and high-intensity interval exercise (HIIE)...
Physiological responses to moderate intensity continuous and high-intensity interval exercise in persons with paraplegia
Study design: Randomized crossover. Objectives: To test differences in the duration and magnitude of physiological response to isocaloric moderate intensity continuous (MICE) and high-intensity interval exercise (HIIE)...
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