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Results: 1747
Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes.
Timothy M Moore, Lijing Cheng, Dane M Wolf, Jennifer Ngo, Mayuko Segawa, Xiaopeng Zhu, Alexander R Strumwasser, Yang Cao, Bethan L Clifford, Alice Ma, Philip Scumpia, Orian S Shirihai, Thomas Q de Aguiar Vallim, Markku Laakso, Aldons J Lusis, Andrea L Hevener, Zhenqi Zhou
Dec 08, 2022
Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue remain unclear....
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Victoria S Burchell, David E Nelson, Alvaro Sanchez-Martinez, Marta Delgado-Camprubi, Rachael M Ivatt, Joe H Pogson, Suzanne J Randle, Selina Wray, Patrick A Lewis, Henry Houlden, Andrey Y Abramov, John Hardy, Nicholas W Wood, Alexander J Whitworth, Heike Laman, Helene Plun-Favreau
Aug 08, 2017
Compelling evidence indicates that two autosomal recessive Parkinson's disease genes, PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box...
Animals Animals Genetically Modified Carbonyl Cyanide m-Chlorophenyl Hydrazone Cell Line Tumor Cells Cultured Drosophila F-Box Proteins Female Fertility FIBROBLASTS Humans Male Microtubule-Associated Proteins Mitochondria Mitochondrial Degradation Mutation Parkinson Disease Protein Transport Proton Ionophores RNA Small Interfering Time Factors Ubiquitin-Protein Ligases Ubiquitination
Jane Smith and Jennifer Disney Capture Faculty Awards
Winthrop University
Jan 01, 0001
Faculty members Jane Smith, English, and Jennifer Disney, political science, were named Distinguished Professor and Outstanding Junior Professor. The awards were presented May 5 during spring commencement.
Published by: Winthrop University
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a...
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease.
I Celardo, AC Costa, S Lehmann, C Jones, N Wood, NE Mencacci, GR Mallucci, SHY Loh, LM Martins
Nov 10, 2017
Mutations in PINK1 and PARKIN cause early-onset Parkinson's disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to...
Animals Disease Models Animal Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Endoplasmic reticulum stress Humans Membrane Proteins Mitochondria Mutation Nerve Degeneration Neuroprotection Parkinson Disease Phosphorylation Protein Serine-Threonine Kinases Signal Transduction Ubiquitin-Protein Ligases Unfolded Protein Response eIF-2 Kinase
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a...
Published by: Scientific reports
Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.
Antonina J Kruppa, Chieko Kishi-Itakura, Thomas A Masters, Joanna E Rorbach, Guinevere L Grice, John Kendrick-Jones, James A Nathan, Michal Minczuk, Folma Buss
Mar 14, 2018
Mitochondrial quality control is essential to maintain cellular homeostasis and is achieved by removing damaged, ubiquitinated mitochondria via Parkin-mediated mitophagy. Here, we demonstrate that MYO6 (myosin VI), a unique...
An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster.
Adeola O Adedara, Ayoade D Babalola, Flora Stephano, Ifeoluwa O Awogbindin, James O Olopade, João BT Rocha, Alexander J Whitworth, Amos O Abolaji
Mar 10, 2022
Loss-of-function mutations in parkin is associated with onset of juvenile Parkinson's disease (PD). Resveratrol is a polyphenolic stilbene with neuroprotective activity. Here, we evaluated the rescue action of resveratrol in...
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models
Abstract: Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson’s disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described...
Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss.
Alice Biosa, Alvaro Sanchez-Martinez, Roberta Filograna, Ana Terriente-Felix, Sarah M Alam, Mariano Beltramini, Luigi Bubacco, Marco Bisaglia, Alexander J Whitworth
Jul 04, 2018
Reactive oxygen species exert important functions in regulating several cellular signalling pathways. However, an excessive accumulation of reactive oxygen species can perturb the redox homeostasis leading to oxidative stress, a...
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1...
Activating Transcription Factor 4 Animals Drosophila Drosophila Proteins Folic Acid Glycine Hydroxymethyltransferase Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Mutagenesis Neuroprotection Parkinson Disease Phenotype Protein Serine-Threonine Kinases RNA Interference RNA Small Interfering Ubiquitin-Protein Ligases Up-Regulation
3D Virtual Learning Environment for Acquisition of Cultural Competence
As educational systems emphasize and experiment with forms of online and remote learning, it is increasingly important to investigate the cultural competence of instructional designers. This chapter addresses the experiences of...
Virtual Communities & Virtual Reality Computer Science and Information Technology Human-Computer Interaction Media and Communications Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Alumni Couple Establishes Scholarship for Financial Planning Students
Winthrop University
Jan 01, 0001
The Mike and Jennifer Fayed Scholarship will support students studying finance with a concentration in financial planning. The Fayeds, who met at Winthrop, live in Belmont, North Carolina.
Published by: Winthrop University
A Comparison of Your Better Life Index and Its Antecedents Across Two Chinese Cultures
Jennifer Gao
Jul 01, 2021
OECD identified 11 topics in Your Better Life Index (YBLI). YBLI is generally accepted as an essential indicator of material living conditions and quality of life. This study compared YBLI in two predominantly Chinese regions...
Published by: IGI Global Scientific Publishing
Board Member's Award Honors Faculty for Exemplary Graduate Instruction
Winthrop University
Jan 01, 0001
The Jane LaRoche Endowed Award for Excellence in Graduate Instruction honors faculty for exemplary instruction in grad-level courses. The 2015 recipient is College of Education faculty member Jennifer Jordan.
Published by: Winthrop University
20th Annual Holiday Pottery Sale Set for Dec. 4
Winthrop University
Jan 01, 0001
The 20th Annual Holiday Pottery Sale will be held Dec. 4 from noon-6 p.m. in Rutledge Building G-10. Jennifer Mecca, ceramics lecturer and studio potter, will be the featured artist.
Published by: Winthrop University
The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference
Abstract Extended CAG trinucleotide repeats (TNR) in the genes huntingtin (HTT ) and androgen receptor (AR ) are the cause of two progressive...
Andrea E Murmann, Monal Patel, Si-Yeon Jeong, Elizabeth T Bartom, A Jennifer Morton, Marcus E Peter
Jan 04, 2023
S.C. Gov. Appoints Counseling Professor to State Board
Winthrop University
Jan 01, 0001
Associate Professor of Counseling Jennifer Jordan has been appointed to the Board of Examiners for Licensure of Professional Counselors, Marriage and Family Therapists and Psycho-Educational Specialists.
Published by: Winthrop University
Associate Professor, P-12 Colleagues Nab S.C. Association of Teacher Educators Awards
Winthrop University
Jan 01, 0001
Sue Spencer won the Exemplary Service to the Teaching Profession Award from the South Carolina Association of Teacher Educators. Local teachers Jennifer Gaston and Adrian Deese won the Cooperating Teacher of the Year Awards.
Published by: Winthrop University
3D Virtual Learning Environment for Acquisition of Cultural Competence
As educational systems emphasize and experiment with forms of online and remote learning, it is increasingly important to investigate the cultural competence of instructional designers. This chapter addresses the experiences of...
Virtual Learning Environments Education Educational Technologies Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
The Evolution of Data Science
Is data science a new field of study or simply an extension or specialization of a discipline that already exists, such as statistics, computer science, or mathematics? This article explores the evolution of data science as a...
Published by: IGI Global Scientific Publishing
Energy or carbon? Exploring the relative size of universal zero carbon and zero energy design spaces
One aim of zero carbon, or zero energy, buildings is to help slow climate change. However, regulatory definitions frequently miss substantial emissions, for example ones associated with the materials the building is constructed...
Energy or carbon? Exploring the relative size of universal zero carbon and zero energy design spaces
One aim of zero carbon, or zero energy, buildings is to help slow climate change. However, regulatory definitions frequently miss substantial emissions, for example ones associated with the materials the building is constructed...
Two Faculty Members Take on Additional Duties July 1
Winthrop University
Jan 01, 0001
Jennifer Leigh Disney, political science, is the new director of Winthrop's Office of Nationally Competitive Awards (ONCA). Keith Benson, health care management, will direct Distinction in Leadership, a new program for students.
Published by: Winthrop University
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