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PESH's Seth Jenny Takes His Love of Running International
Winthrop University
Jan 01, 0001
Jenny has run at least 29,301 miles since 1996. He's run in places such as Anchorage, Alaska; Scotland; and Athens, Greece.
Published by: Winthrop University
Jenny Lind, Voice, Celebrity
F Vella
Apr 13, 2017
Voice has a long history in modern Western culture as a transparent signifier of subjectivity and presence. This ideology of immediacy has meant that exploration of singing voices as mediated has mostly been confined to classic...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Lesion site and therapy time predict responses to a therapy for anomia after stroke
Thomas MH Hope, Davide Nardo, Rachel Holland, Sasha Ondobaka, Haya Akkad, Cathy J Price, Alexander P Leff, Jenny Crinion
Sep 20, 2021
Stroke is a leading cause of disability, and language impairments (aphasia) after stroke are both common and particularly feared. Most stroke survivors with aphasia exhibit anomia (difficulties with naming common objects), but...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Embedding action research in teacher candidate elementary classroom and physical education settings
This article is primarily designed to assist teacher candidates and classroom teachers in conducting action research. Where the authors ask teacher candidates to discuss or share their research drafts with cooperating teachers...
Published by: Winthrop University
Efficacy of spoken word comprehension therapy in patients with chronic aphasia
Victoria Fleming, Sonia Brownsett, Anna Krason, Maria A Maegli, Henry Coley-Fisher, Yean-Hoon Ong, Davide Nardo, Rupert Leach, David Howard, Holly Robson, Elizabeth Warburton, John Ashburner, Cathy J Price, Jenny T Crinion, Alexander P Leff
Oct 28, 2020
OBJECTIVE: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, 'Listen-In', and examined the relation between brain...
Efficacy of spoken word comprehension therapy in patients with chronic aphasia
Victoria Fleming, Sonia Brownsett, Anna Krason, Maria A Maegli, Henry Coley-Fisher, Yean-Hoon Ong, Davide Nardo, Rupert Leach, David Howard, Holly Robson, Elizabeth Warburton, John Ashburner, Cathy J Price, Jenny T Crinion, Alexander P Leff
Nov 09, 2020
Objective: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, ‘Listen-In’, and examined the relation between brain...
Published by: BMJ Publishing Group
Facilitating Teacher Reflection through a mutual understanding of the Characteristics of Exemplary Teachers
Teachers meet challenges as they make a plethora of daily choices. It is a responsibility to learn from past choices. An exemplary teacher is a person who accepts the challenge of lifelong learning experiences in the domains of...
pedagogy Teacher Education Reflective Practitioner teacher assessment Education Higher Education and Teaching Scholarship of Teaching and Learning Teacher Education and Professional Development
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
A homozygous variant disrupting the PIGH start-codon is associated with developmental delay, epilepsy, and microcephaly.
Alistair T Pagnamenta, Yoshiko Murakami, Consuelo Anzilotti, Hannah Titheradge, Adam J Oates, Jenny Morton, DDD Study, Taroh Kinoshita, Usha Kini, Jenny C Taylor
Feb 07, 2019
Defective glycosylphosphatidylinositol (GPI)-anchor biogenesis can cause a spectrum of predominantly neurological problems. For eight genes critical to this biological process, disease associations are not yet reported. Scanning...
GPI-anchor biogenesis PIGH developmental delay Exome Microcephaly phosphatidylinositol N-acetylglucosaminyltransferase Adolescent Animals Child Child Preschool Codon Initiator Cricetinae Developmental Disabilities Epilepsy Exome Female Glycosylphosphatidylinositols Humans Male Membrane Proteins Microcephaly Mutation Pedigree
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
Ionic immune suppression within the tumour microenvironment limits T cell effector function.
Robert Eil, Suman K Vodnala, David Clever, Christopher A Klebanoff, Madhusudhanan Sukumar, Jenny H Pan, Douglas C Palmer, Alena Gros, Tori N Yamamoto, Shashank J Patel, Geoffrey C Guittard, Zhiya Yu, Valentina Carbonaro, Klaus Okkenhaug, David S Schrump, W Marston Linehan, Rahul Roychoudhuri, Nicholas P Restifo
Jun 27, 2018
Tumours progress despite being infiltrated by tumour-specific effector T cells. Tumours contain areas of cellular necrosis, which are associated with poor survival in a variety of cancers. Here, we show that necrosis releases...
Animals cations Monovalent Humans Immune Tolerance Immunotherapy Kv1.3 Potassium Channel Male Melanoma Membrane Potentials Mice Necrosis Potassium Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell Signal Transduction Survival Analysis T-Lymphocytes TOR Serine-Threonine Kinases Tumor Escape Tumor Microenvironment
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
Heimat and the place of humans in the world
A H Goodbody
Jan 01, 0001
This essay considers the human-nature relationship in modern Heimat (homeland) discourse, and its depiction in literary representations of Heimat. The first part examines the environmental turn in thinking on Heimat in the...
Heimat and the place of humans in the world
A H Goodbody
Jan 01, 0001
This essay considers the human-nature relationship in modern Heimat (homeland) discourse, and its depiction in literary representations of Heimat. The first part examines the environmental turn in thinking on Heimat in the...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
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