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Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies.
Historically tools and technologies facilitated scientific discoveries. Steroid hormone research is not an exception. Unfortunately, the dramatic advancement of the field faded this research area and flagged it as a solved...
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells.
Sougata Roy, James Sipthorp, Bidesh Mahata, Jhuma Pramanik, Marco L Hennrich, Anne-Claude Gavin, Steven V Ley, Sarah A Teichmann
May 13, 2021
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Jhuma Pramanik, Jani Huuhtanen, Gozde Kar, Roser Vento-Tormo, Tzachi Hagai, Xi Chen, Muzlifah A Haniffa, Jacqueline D Shields, Sarah A Teichmann
May 01, 2020
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, Tomás Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B Meyer, Zhichao Miao, Andrew NJ McKenzie, Bidesh Mahata, Sarah A Teichmann
May 14, 2019
BACKGROUND: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory...
Genome-wide XBP1 chromatin occupancy IRE1a IRE1a-XBP1 pathway RNA-seq T helper cell activation Th2 lymphocyte proliferation Th2 transcriptome xbp1 XBP1 ChIP-seq Animals Base Sequence Cell Cycle Cell Differentiation Cell Proliferation Cytokines Endoribonucleases Female Gene Expression Regulation Genome-Wide Association Study Lymphocyte Activation Mice Inbred C57BL Mice Transgenic Protein Serine-Threonine Kinases Signal Transduction Stress Physiological Th2 Cells Up-Regulation X-Box Binding Protein 1
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 17, 2020
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 28, 2021
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A Fonseca, Kousik Kundu, Lia S Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J Adams, Jacqueline D Shields, Sarah A Teichmann
Jul 30, 2020
Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to evade...
Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation.
Valentina Proserpio, Andrea Piccolo, Liora Haim-Vilmovsky, Gozde Kar, Tapio Lönnberg, Valentine Svensson, Jhuma Pramanik, Kedar Nath Natarajan, Weichao Zhai, Xiuwei Zhang, Giacomo Donati, Melis Kayikci, Jurij Kotar, Andrew NJ McKenzie, Ruddy Montandon, Oliver Billker, Steven Woodhouse, Pietro Cicuta, Mario Nicodemi, Sarah A Teichmann
May 16, 2019
BACKGROUND: Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model...
Adaptive Immunity CD4+ T cells Cell Cycle DIFFERENTIATION Live imaging Single-cell RNA-seq Animals CD4-Positive T-Lymphocytes Cell Differentiation Cell Proliferation Cells Cultured Cytokines Female Gene Expression Profiling Malaria Mice Mice Inbred C57BL Models Biological Sequence Analysis RNA Single-Cell Analysis Transcriptome
Material flow and sustainability analyses of biorefining of municipal solid waste
This paper presents material flow and sustainability analyses of novel mechanical biological chemical treatment system for complete valorization of municipal solid waste (MSW). It integrates material recovery facility (MRF);...
Biomass Biorefineries Municipal solid waste management levulinic acid biofuels /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Material flow and sustainability analyses of biorefining of municipal solid waste
This paper presents material flow and sustainability analyses of novel mechanical biological chemical treatment system for complete valorization of municipal solid waste (MSW). It integrates material recovery facility (MRF);...
Biomass Biorefineries Municipal solid waste management levulinic acid biofuels /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Mapping Rora expression in resting and activated CD4+ T cells.
Liora Haim-Vilmovsky, Johan Henriksson, Jennifer A Walker, Zhichao Miao, Eviatar Natan, Gozde Kar, Simon Clare, Jillian L Barlow, Evelina Charidemou, Lira Mamanova, Xi Chen, Valentina Proserpio, Jhuma Pramanik, Steven Woodhouse, Anna V Protasio, Mirjana Efremova, Julian L Griffin, Matt Berriman, Gordon Dougan, Jasmin Fisher, John C Marioni, Andrew N J McKenzie, Sarah A Teichmann
Jun 19, 2021
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an...
Published by: PLOS ONE
Mapping Rora expression in resting and activated CD4+ T cells
Liora Haim-Vilmovsky, Johan Henriksson, Jennifer A. Walker, Zhichao Miao, Eviatar Natan, Gozde Kar, Simon Clare, Jillian L. Barlow, Evelina Charidemou, Lira Mamanova, Xi Chen, Valentina Proserpio, Jhuma Pramanik, Steven Woodhouse, Anna V. Protasio, Mirjana Efremova, Julian L. Griffin, Matt Berriman, Gordon Dougan, Jasmin Fisher, John C. Marioni, Andrew N. J. McKenzie, Sarah A. Teichmann
May 20, 2021
Erratum to
Valentina Proserpio, Andrea Piccolo, Liora Haim-Vilmovsky, Gozde Kar, Tapio Lönnberg, Valentine Svensson, Jhuma Pramanik, Kedar Nath Natarajan, Weichao Zhai, Xiuwei Zhang, Giacomo Donati, Melis Kayikci, Jurij Kotar, Andrew NJ McKenzie, Ruddy Montandon, Kylie R James, Daniel Fernandez-Ruiz, William R Heath, Ashraful Haque, Oliver Billker, Steven Woodhouse, Pietro Cicuta, Mario Nicodemi, Sarah A Teichmann
May 16, 2019
Novel integrated mechanical biological chemical treatment (MBCT) systems for the production of levulinic acid from fraction of municipal solid waste
This paper, for the first time, reports integrated conceptual MBCT/biorefinery systems for unlocking the value of organics in municipal solid waste (MSW) through the production of levulinic acid (LA by 5 wt%) that increases...
circular economy Combined heat and power (CHP) Metal and energy and material resource recovery from MSW Municipal solid waste management Refuse /dk/atira/pure/subjectarea/asjc/1500/1502 name=Bioengineering /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Novel integrated mechanical biological chemical treatment (MBCT) systems for the production of levulinic acid from fraction of municipal solid waste
This paper, for the first time, reports integrated conceptual MBCT/biorefinery systems for unlocking the value of organics in municipal solid waste (MSW) through the production of levulinic acid (LA by 5 wt%) that increases...
circular economy Combined heat and power (CHP) Metal and energy and material resource recovery from MSW Municipal solid waste management Refuse /dk/atira/pure/subjectarea/asjc/1500/1502 name=Bioengineering /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Mapping Rora expression in resting and activated CD4+ T cells.
Liora Haim-Vilmovsky, Johan Henriksson, Jennifer A Walker, Zhichao Miao, Eviatar Natan, Gozde Kar, Simon Clare, Jillian L Barlow, Evelina Charidemou, Lira Mamanova, Xi Chen, Valentina Proserpio, Jhuma Pramanik, Steven Woodhouse, Anna V Protasio, Mirjana Efremova, Julian L Griffin, Matt Berriman, Gordon Dougan, Jasmin Fisher, John C Marioni, Andrew NJ McKenzie, Sarah A Teichmann
Jul 20, 2021
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an...
Animals Antigens Helminth CD4-Positive T-Lymphocytes Cells Cultured Cytokines Disease Models Animal Female Gene Expression Regulation Lymphocyte Activation MACROPHAGES Mice Mice Inbred C57BL Mice Knockout Mice Transgenic Nippostrongylus Nuclear Receptor Subfamily 1 Group F Member 1 Pneumonia Strongylida Infections Th2 Cells
Light-triggered syneresis of a water insoluble peptide-hydrogel effectively removes small molecule waste contaminants.
A short peptide based hydrogel exhibits aqueous insolubility, thixotropy and efficient light induced syneresis. Upon irradiation with UV light, the hydrogel shrinks and expells ∼50% of the solvent. Syneresis is caused by...
Role of bioenergy, biorefinery and bioeconomy in sustainable development
Jhuma Sadhukhan, Elias Martinez-Hernandez, Richard J. Murphy, Denny K.s. Ng, Mimi H. Hassim, Kok Siew Ng, Wan Yoke Kin, Ida Fahani Md Jaye, Melissa Y. Leung Pah Hang, Viknesh Andiappan
Jan 01, 2018
Malaysia has a plethora of biomass that can be utilized in a sustainable manner to produce bio-products for circular green economy. At the 15th Conference of Parties in Copenhagen, Malaysia stated to voluntarily reduce its...
Adaptation and resilience circular economy Climate Change Mitigation Lignocellulosic biorefinery Malaysia development plan Resource recovery from waste (RRfW) sustainable development goals /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Role of bioenergy, biorefinery and bioeconomy in sustainable development
Jhuma Sadhukhan, Elias Martinez-Hernandez, Richard J. Murphy, Denny K.s. Ng, Mimi H. Hassim, Kok Siew Ng, Wan Yoke Kin, Ida Fahani Md Jaye, Melissa Y. Leung Pah Hang, Viknesh Andiappan
Jan 01, 2018
Malaysia has a plethora of biomass that can be utilized in a sustainable manner to produce bio-products for circular green economy. At the 15th Conference of Parties in Copenhagen, Malaysia stated to voluntarily reduce its...
Adaptation and resilience circular economy Climate Change Mitigation Lignocellulosic biorefinery Malaysia development plan Resource recovery from waste (RRfW) sustainable development goals /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Speckle Noise Removal by SORAMA Segmentation in Digital Image Processing to Facilitate Precise Robotic Surgery
Sabyasachi Pramanik, Jeba Kumar R. J. S., Roopa Jayasingh J., Deepika Telagathoti, K. Sagayam, Om Jena, Samir Bandyopadhyay, K. Sagayam
Jan 01, 2022
Kidney stones are renal calculi that are formed due to the collection of calcium and uric acid. The major symptom for the existence of these renal calculi is severe pain, especially when it travels down the urethras To detect...
Published by: IGI Global Scientific Publishing