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Results: 91
QT Prolongation in Critically Ill Patients With SARS-CoV-2 Infection.
Wasim S El Nekidy, Khalid Almuti, Hazem ElRefaei, Bassam Atallah, Lana M Mohammad, Wael Almahmeed, Mohamed Badr, Khaled Abdallah, Fadi Hamed, Jihad Mallat
Jan 28, 2022
BACKGROUND: Several reports linked the use of repurposed drugs such as hydroxychloroquine (HCQ), azithromycin, lopinavir/ritonavir, and favipiravir with QT interval prolongation in patients with SARS-CoV2 infection. Little is...
Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid
The pathophysiology of aortic dissection is poorly understood, and its risk is resistant to medical treatment. Most studies have focused on a proposed pathogenic role of transforming growth factor-β in Marfan disease and related...
actin Aneurysm Extracellular Fluid pericyte vasa vasorum aortic dissection Animals Aorta Thoracic Aortic Aneurysm Thoracic Dilatation Pathologic Extracellular Fluid Extracellular Matrix Gene Expression Regulation Genetic Predisposition to Disease Humans Mechanotransduction Cellular Microcirculation Microvessels Models Biological Models Cardiovascular Pressure Vasoconstriction
The CXCL10/CXCR3 Axis and Cardiac Inflammation
Animals Humans Cardiovascular Diseases Inflammation vitamin D Immunoglobulins Intravenous Receptors Lysosphingolipid Interleukin-2 Immunotherapy Signal Transduction T-Lymphocytes Regulatory Chemokine CXCL10 Receptors CXCR3 Chemokine CXCL11
Published by: Journal of immunology research
Sialyltransferase activity and atherosclerosis.
This is the author accepted manuscript. The final version is available from American Heart Association at http://dx.doi.org/10.1161/CIRCRESAHA.114.303480.
NLRP3 inflammasome pathways in atherosclerosis.
Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns...
Targeting B cells in atherosclerosis
B lymphocytes B-Cell Activating Factor Antibodies Atherosclerosis belimumab Cardiovascular Diseases Rituximab Animals Atherosclerosis B-Lymphocyte Subsets Disease Models Animal Humans Immunologic Factors Inflammation Mediators Molecular Targeted Therapy Myocardial Infarction Phenotype Signal Transduction Translational Research Biomedical
The CANTOS Trial
The results of the CANTOS trial provide exciting evidence in support of the inflammatory hypothesis of atherosclerosis in humans, and is the first phase III clinical trial to show clinical benefit of a targeted anti-inflammatory...
Atherosclerosis Coronary Artery Disease Inflammation Interleukins translational medical research Anti-Inflammatory Agents Antibodies Monoclonal Antibodies Monoclonal Humanized Atherosclerosis Cardiology Clinical Trials Phase III as Topic Coronary Artery Disease Humans Randomized Controlled Trials as Topic Treatment Outcome
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
Plan B (-cell) in atherosclerosis.
Atherosclerosis is a leading cause of death worldwide. It is a complex chronic inflammatory disease involving interactions between vascular, circulating and immune cells. B cells play an important role in chronic inflammation...
Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response.
Marc Clément, Gemma Basatemur, Leanne Masters, Lauren Baker, Patrick Bruneval, Takao Iwawaki, Manfred Kneilling, Sho Yamasaki, Jane Goodall, Ziad Mallat
Nov 14, 2016
Monocytes and macrophages in abdominal aortic aneurysm.
Juliette Raffort, Fabien Lareyre, Marc Clément, Réda Hassen-Khodja, Giulia Chinetti, Ziad Mallat
Jun 21, 2018
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical and endovascular repair of AAA have been achieved...
PET Imaging of Post-infarct Myocardial Inflammation.
PURPOSE OF REVIEW: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. RECENT FINDINGS: Dysregulated immune responses after myocardial infarction are associated...
Vascular smooth muscle cells in atherosclerosis.
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media...
Micro-RNAs in abdominal aortic aneurysms
Abdominal aortic aneurysm (AAA) is a major health concern and may be associated with high rates of mortality linked to acute complications. Diagnosis and treatment are, respectively, based on imaging and surgical techniques....
2019 ATVB Plenary Lecture: Interleukin-2 Therapy in Cardiovascular Disease
Regulatory T cells and type-2 innate lymphoid cells represent 2 subsets of immune cells, which have been shown in preclinical models to be important in atherosclerosis and myocardial repair. Regulatory T cells play a crucial...
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