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Results: 7654
f-scLVM
Florian Buettner, Naruemon Pratanwanich, Davis J McCarthy, John C Marioni, Oliver Stegle
Mar 26, 2018
Single-cell RNA-sequencing (scRNA-seq) allows studying heterogeneity in gene expression in large cell populations. Such heterogeneity can arise due to technical or biological factors, making decomposing sources of variation...
Gene set annotations Single-cell RNA-seq Sparse factor analysis Animals Computer Simulation Databases as Topic Factor Analysis Statistical Gene Expression Regulation Mice Models Theoretical Mouse embryonic stem cells Neurons Reproducibility of Results Sequence Analysis RNA Single-Cell Analysis Software
A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening.
Bárbara B Sousa, Marcos FQ Sousa, Marta C Marques, João D Seixas, José A Brito, Pedro M Matias, Gonçalo JL Bernardes, António Roldão
Sep 15, 2020
Bone Marrow Tyrosine kinase in the chromosome X (BMX) is a TEC family kinase associated with numerous pathological pathways in cancer cells. Covalent inhibition of BMX activity holds promise as a therapeutic approach against...
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
Decision-Making Model to Assess Organizational Climate in Healthcare Organizations
Organizational climate impacts on the employee's well-being, commitment, and positive behavior. Most studies to assess climate in healthcare organizations use qualitative and/or statistical methods. Here, the authors propose a...
Published by: IGI Global Scientific Publishing
A Systematic Literature Review on Hospitality Analytics
With the growth of data generated by all systems involved in a hotel, terms like big data and business analytics (BA) gain strength within the hotel industry. Business analytics can be used in hospitality management to increase...
Published by: IGI Global Scientific Publishing
Bioaugmentation of activated sludge with <i>Achromobacter denitrificans</i> PR1 for enhancing the biotransformation of sulfamethoxazole and its human conjugates in real wastewater
P. Y. Nguyen, G. Carvalho, Fabio Polesel, Elena Torresi, Alexandre M. Rodrigues, João E. Rodrigues, Vitor Vale Cardoso, Maria João Benoliel, Benedek Gy Plósz, M. A.M. Reis, A. Oehmen
Nov 15, 2018
Achromobacter denitrificans PR1 has previously shown potential to degrade the antibiotic sulfamethoxazole, whereby sulfamethoxazole biotransformation was stimulated in the presence of biogenic substrates. This study examined...
Antibiotics Cometabolism modelling N-acetyl-SMX Retransformation SMX-N-Glucuronide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Bioaugmentation of activated sludge with <i>Achromobacter denitrificans</i> PR1 for enhancing the biotransformation of sulfamethoxazole and its human conjugates in real wastewater
P. Y. Nguyen, G. Carvalho, Fabio Polesel, Elena Torresi, Alexandre M. Rodrigues, João E. Rodrigues, Vitor Vale Cardoso, Maria João Benoliel, Benedek Gy Plósz, M. A.M. Reis, A. Oehmen
Nov 15, 2018
Achromobacter denitrificans PR1 has previously shown potential to degrade the antibiotic sulfamethoxazole, whereby sulfamethoxazole biotransformation was stimulated in the presence of biogenic substrates. This study examined...
Antibiotics Cometabolism modelling N-acetyl-SMX Retransformation SMX-N-Glucuronide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Homer F. Swift, 1920
The Rockefeller University
Jan 01, 0001
Homer F. Swift, M.D. Trench Fever
Lecture delivered January 10th, 1920
Published by: J.B. Lippincott Company
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.
João D Seixas, Bárbara B Sousa, Marta C Marques, Ana Guerreiro, Rui Traquete, Tiago Rodrigues, Inês S Albuquerque, Marcos FQ Sousa, Ana R Lemos, Pedro MF Sousa, Tiago M Bandeiras, Di Wu, Shelby K Doyle, Carol V Robinson, Angela N Koehler, Francisco Corzana, Pedro M Matias, Gonçalo JL Bernardes
Oct 01, 2021
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with...
The management of COVID-19 cases through telemedicine in Brazil.
Alfredo Montelongo, João Luiz Becker, Rudi Roman, Elise Botteselle de Oliveira, Roberto Nunes Umpierre, Marcelo Rodrigues Gonçalves, Rodolfo Silva, Katarzyna Doniec, Ali K Yetisen
Aug 14, 2021
In Dec 2020 Brazil became one of the worldwide epicenters of the COVID-19 pandemic with more than 7.2M reported cases. Brazil has a large territory with unequal distribution of healthcare resources including physicians. Resource...
Systematics of the α′ expansion in F-theory
Abstract: Extracting reliable low-energy information from string compactifications notoriously requires a detailed understanding of the UV sensitivity of the corresponding effective field theories. Despite past efforts in...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
Biocultural predictors of motor coordination among pre-pubertal boys and girls
Leonardo Luz, João Valente-dos-Santos, Tatiana Luz, Paulo Sousae-e-Silva, João P. Duarte, Aristides Machado-Rodrigues, Andre Seabra, Rute Santos, Sean P. Cumming, Manuel J. Coelho-e-Silva
Feb 01, 2018
This study aimed to predict motor coordination from a matrix of biocultural factors. The sample included 173 children (89 boys, 84 girls) aged 7-9 years assessed on the Körperkoordinationtest für Kinder test battery....
Binding hotspots of BAZ2B bromodomain
Fleur M Ferguson, David M Dias, João PGLM Rodrigues, Hans Wienk, Rolf Boelens, Alexandre MJJ Bonvin, Chris Abell, Alessio Ciulli
Oct 01, 2014
Experimental and computational studies of the copper borate complexes [(NHC)Cu(HBEt<sub>3</sub>)] and [(NHC)Cu(HB(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>)]
Lee R. Collins, Nasir A. Rajabi, Stuart A. Macgregor, Mary F. Mahon, Michael K. Whittlesey
Dec 05, 2016
The synthesis of the Cu-borate complexes [(6Mes)Cu(HBR3)] featuring the unusual [HBEt3]− (5) and [HB(C6F5)3]− (6) ligands is described. Experimental...
Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase.
Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, Liang Deng, Yanrong Shi, Peter F Leadlay, Heng Song, Kui Hong, Zixin Deng, Yuhui Sun
Oct 19, 2020
The colinearity of canonical modular polyketide synthases, which creates a direct link between multienzyme structure and the chemical structure of the biosynthetic end-product, has become a cornerstone of knowledge-based genome...
Systematics of the α′ expansion in F-theory
Extracting reliable low-energy information from string compactifications
notoriously requires a detailed understanding of the UV sensitivity of the
corresponding effective field theories. Despite past efforts in...
Biocultural predictors of motor coordination among pre-pubertal boys and girls
Leonardo Luz, João Valente-dos-Santos, Tatiana Luz, Paulo Sousae-e-Silva, João P. Duarte, Aristides Machado-Rodrigues, Andre Seabra, Rute Santos, Sean P. Cumming, Manuel J. Coelho-e-Silva
Feb 01, 2018
This study aimed to predict motor coordination from a matrix of biocultural factors. The sample included 173 children (89 boys, 84 girls) aged 7-9 years assessed on the Körperkoordinationtest für Kinder test battery....
Pathogens and host immunity in the ancient human oral cavity.
Christina Warinner, João F Matias Rodrigues, Rounak Vyas, Christian Trachsel, Natallia Shved, Jonas Grossmann, Anita Radini, Y Hancock, Raul Y Tito, Sarah Fiddyment, Camilla Speller, Jessica Hendy, Sophy Charlton, Hans Ulrich Luder, Domingo C Salazar-García, Elisabeth Eppler, Roger Seiler, Lars H Hansen, José Alfredo Samaniego Castruita, Simon Barkow-Oesterreicher, Kai Yik Teoh, Christian D Kelstrup, Jesper V Olsen, Paolo Nanni, Toshihisa Kawai, Eske Willerslev, Christian von Mering, Cecil M Lewis, Matthew J Collins, M Thomas P Gilbert, Frank Rühli, Enrico Cappellini
Nov 22, 2018
Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional...
The management of COVID-19 cases through telemedicine in Brazil
Alfredo Montelongo, João Luiz Becker, Rudi Roman, Elise Botteselle de Oliveira, Roberto Nunes Umpierre, Marcelo Rodrigues Gonçalves, Rodolfo Silva, Katarzyna Doniec, Ali K. Yetisen
Jul 28, 2021
In Dec 2020 Brazil became one of the worldwide epicenters of the COVID-19 pandemic with more than 7.2M reported cases. Brazil has a large territory with unequal distribution of healthcare resources including physicians. Resource...
Developing local RG
Abstract: In this paper we study various forms of RG and apply these to the BFSS model of N coincident D0-branes. Firstly, as a warm-up, we perform standard Wilsonian RG, investigating the conditions under which supersymmetry is...
Experimental and computational studies of the copper borate complexes [(NHC)Cu(HBEt<sub>3</sub>)] and [(NHC)Cu(HB(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>)]
Lee R. Collins, Nasir A. Rajabi, Stuart A. Macgregor, Mary F. Mahon, Michael K. Whittlesey
Dec 05, 2016
The synthesis of the Cu-borate complexes [(6Mes)Cu(HBR3)] featuring the unusual [HBEt3]− (5) and [HB(C6F5)3]− (6) ligands is described. Experimental...
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