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Results: 783
Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance.
Here we investigate the effects of expressing an activated mutant of Notch (ICD-E) in an inducible transgenic mouse model. Hepatic expression of ICD-E in adult animals has no detectable phenotype, but simultaneous induction of...
Human keratinocytes have two interconvertible modes of proliferation.
Amit Roshan, Kasumi Murai, Joanna Fowler, Benjamin D Simons, Varvara Nikolaidou-Neokosmidou, Philip H Jones
Nov 23, 2015
Concert on the Lawn Set for Sept. 24
Winthrop University
Jan 01, 0001
The Department of Music will host a "Concert on the Lawn" Sept. 24 outside Byrnes Auditorium. John Fowler, Michael Hough and Sarita Maxwell will be featured faculty soloists.
Published by: Winthrop University
Prevention Is Better Than Cure
One of the common uses of artificial intelligence in higher education is learning dashboards, which aim at collecting and analyzing student information and providing feedback to students. Despite limited studies on dashboards in...
Artificial Intelligence Education Educational Technologies Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 16, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
GFAP Expression of Radial Glial Cells of the Regenerating Spinal Cord of Axolotls
Erin Fowler
Jan 01, 0001
Unlike humans, axolotls (Ambystoma mexicanum) possess the ability to completely regenerate their spinal cord following injury. It is theorized that the population of radial glial cells in the spinal cord act as the progenitors...
Published by: Ursinus College
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 19, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
Winthrop Alumna Will Represent Education Superintendent on Board of Trustees
Winthrop University
Jan 01, 0001
Fowler, a resident of Piedmont, South Carolina, is a deputy state superintendent at the S.C. State Department of Education. She has experience as a classroom teacher at the elementary, middle and high school level, and has...
Published by: Winthrop University
The formation of three-grain junctions during solidification. Part I
Abstract: The thermodynamic equilibrium dihedral angle at grain junctions in crystalline rocks is set by the grain boundary interfacial surface energies, but the long times required to attain equilibrium mean that the observed...
Interdisciplinary Exploration of the Impact of Tree and Shrub Species on Soil Health at the Ursinus College Food Forest
Lexi Fowler
Jan 01, 0001
The Ursinus College Food Forest (UCFF) represents a transformation from an herbaceous pasture to a forested system characterized by long-lived wood tree and shrub species. This project sought to understand, quantify, and educate...
interdisciplinary food forest Soil Health Ceramics accessibility roots Agricultural Education Agronomy and Crop Sciences Biodiversity Botany Environmental Microbiology and Microbial Ecology Environmental Sciences Forest Biology
Published by: Ursinus College
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Bartomeu Colom, Maria P Alcolea, Gabriel Piedrafita, Michael WJ Hall, Agnieszka Wabik, Stefan C Dentro, Joanna C Fowler, Albert Herms, Charlotte King, Swee Hoe Ong, Roshan K Sood, Moritz Gerstung, Inigo Martincorena, Benjamin A Hall, Philip H Jones
Apr 28, 2020
ADAM10 Protein Amyloid Precursor Protein Secretases Animals Cell Lineage Diethylnitrosamine Epithelium esophagus Female High-Throughput Nucleotide Sequencing Male Membrane Proteins Mice Inbred C57BL Mice Transgenic Mutation Receptor Notch1 Receptor Notch2 Reproducibility of Results Tumor Suppressor Protein p53
Somatic mutant clones colonize the human esophagus with age.
Iñigo Martincorena, Joanna C Fowler, Agnieszka Wabik, Andrew RJ Lawson, Federico Abascal, Michael WJ Hall, Alex Cagan, Kasumi Murai, Krishnaa Mahbubani, Michael R Stratton, Rebecca C Fitzgerald, Penny A Handford, Peter J Campbell, Kourosh Saeb-Parsy, Philip H Jones
Dec 06, 2018
The formation of three-grain junctions during solidification. Part II
Abstract We provide a simple geometric theory of crystal growth which predicts the shape and final dihedral angle of three-grain junctions of an augite crystal with two plagioclase grains. The...
The formation of three-grain junctions during solidification. Part II
Abstract We provide a simple geometric theory of crystal growth which predicts the shape and final dihedral angle of three-grain junctions of an augite crystal with two plagioclase grains. The...
Selection of oncogenic mutant clones in normal human skin varies with body site.
Joanna C Fowler, Charlotte King, Christopher Bryant, Michael Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Oct 23, 2020
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by...
The formation of three-grain junctions during solidification. Part I
Abstract The thermodynamic equilibrium dihedral angle at grain junctions in crystalline rocks is set by the grain boundary interfacial surface energies, but the long times required to attain...
Winthrop English Majors Recognized at International Conference
Winthrop University
Jan 01, 0001
Senior Alex Muller, president of the Winthrop Iota Mu Chapter of Sigma Tau Delta and editor of the Winthrop Literary Magazine The Anthology, was awarded the $4,000 Sigma Tau Delta Senior Scholarship for his outstanding scholarly...
Published by: Winthrop University
Use of machine learning to identify a T cell response to SARS-CoV-2.
M Saad Shoukat, Andrew D Foers, Stephen Woodmansey, Shelley C Evans, Anna Fowler, Elizabeth J Soilleux
Feb 24, 2021
The identification of SARS-CoV-2-specific T cell receptor (TCR) sequences is critical for understanding T cell responses to SARS-CoV-2. Accordingly, we reanalyze publicly available data from SARS-CoV-2-recovered patients who had...
Building research capacity in Education
Zoe Louise Fowler, Adela Baird, Susan MB Davies, Richard Procter, Stephen Baron, Jane Salisbury
Apr 13, 2010
There is a pressing need to build research capacity in Education across the UK to combat the effects of the ageing research population and the increasing polarisation between research-intensive institutions and the remainder of...
Published by: University of Cambridge
Changes in Bone Mineral Density During and After Lactation in Ugandan Women With HIV on Tenofovir-Based Antiretroviral Therapy.
Florence Nabwire, Ann Prentice, Matthew M Hamill, Mary Glenn Fowler, Josaphat Byamugisha, Adeodata Kekitiinwa, Gail R Goldberg
Jul 17, 2020
Antiretroviral therapy (ART) in people living with human immunodeficiency virus (HIV) is associated with bone loss, but data are limited in lactation, when physiological bone mineral mobilization is occurring. This research...
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