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S.C. Governor Appoints Gary Williams to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
HIGHLIGHTS Williams will immediately fill the seat held by Don Long, who was appointed to the seat by former S.C. Governor Nikki Haley. Williams is the CEO of Williams & Fudge Corp., a financial services firm in Rock Hill....
Published by: Winthrop University
Dorothy W. Williams '60 Endows Fund for Family and Consumer Sciences
Winthrop University
Jan 01, 0001
The Dorothy W. Williams Family and Consumer Sciences Fund will provide funds for the family and consumer sciences program to be used for scholarship awards; travel for student and faculty development; activities of the Winthrop...
Published by: Winthrop University
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective...
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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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Tennessee Williams' ''A Streetcar Named Desire'' Returns to Winthrop Feb. 17
Winthrop University
Jan 01, 0001
Russell Luke, instructor of theatre, will direct Tennessee Williams' classic play, which runs Feb. 17-21. "A Streetcar Named Desire" was last performed at Winthrop in 1960.
Published by: Winthrop University
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Published by:
Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

There is ongoing debate about the role of G protein receptor kinases (GRKs) in agonist-induced desensitization of the μ opioid receptor (MOPr) in brain neurons (see Williams et al., 2013, Pharmacol Rev 15;223-254). In the...

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The shaken realist
Abstract: Bernard Williams thought that philosophy should address real human concerns felt beyond academic philosophy. But what wider concerns are addressed by Ethics and the Limits of Philosophy, a book he introduces as being...
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Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

There is ongoing debate about the role of G protein receptor kinases (GRKs) in agonist-induced desensitization of the μ opioid receptor (MOPr) in brain neurons (see Williams et al., 2013, Pharmacol Rev 15;223-254). In the...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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