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Results: 22099
Glycaemic control targets after traumatic brain injury
Jeroen Hermanides, Mark P Plummer, Mark Finnis, Adam M Deane, Jonathan P Coles, David K Menon
Jan 29, 2018
BACKGROUND: Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing intensive with conventional glycaemic...
Anaesthesia for magnetic resonance imaging and positron emission tomography.
PURPOSE OF REVIEW: This article reviews the important aspects of managing patients undergoing anaesthesia and monitoring for MRI and PET. RECENT FINDINGS: The use of MRI and PET is expanding and an increasing number of...
Imaging in the diagnosis and prognosis of traumatic brain injury.
INTRODUCTION: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Improved understanding of the impact of head injury and the extent and development of neuronal loss and cognitive dysfunction could...
1109 Neurosciences Biomedical Clinical Medicine and Science Injury - Childhood Injuries Injury - Trauma - (Head and Spine) Neurosciences Injury - Traumatic brain injury Diagnostic Radiology Pediatric Injury (total) Accidents/Adverse Effects Brain Disorders Neurological Injuries and accidents 4.2 Evaluation of markers and technologies
Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.
Thomas Geeraerts, Jonathan P Coles, Franklin I Aigbirhio, John D Pickard, David K Menon, Tim D Fryer, Young T Hong
Jun 18, 2018
OBJECTIVE: [(11)C]Flumazenil ([(11)C]FMZ) positron emission tomography (PET) can be used as a measure of neuronal loss. The purpose of this study was to validate reference tissue kinetic modelling of [(11)C]FMZ PET within a...
Magnetic resonance imaging and thermal injury.
We read with interest the recent case report by Tanaka and coauthors (Tanaka R, Yumoto T, Shiba N, et al: Overheated and melted intracranial pressure transducer as cause of thermal brain injury during magnetic resonance imaging....
Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure.
Thomas Geeraerts, Virginia FJ Newcombe, Jonathan P Coles, Maria Giulia Abate, Iain E Perkes, Peter JA Hutchinson, Jo G Outtrim, Dot A Chatfield, David K Menon
Jun 17, 2011
INTRODUCTION: The dural sheath surrounding the optic nerve communicates with the subarachnoid space, and distends when intracranial pressure is elevated. Magnetic resonance imaging (MRI) is often performed in patients at risk...
Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.
Negin Holland, P Simon Jones, George Savulich, Julie K Wiggins, Young T Hong, Tim D Fryer, Roido Manavaki, Selena Milicevic Sephton, Istvan Boros, Maura Malpetti, Frank H Hezemans, Franklin I Aigbirhio, Jonathan P Coles, John O'Brien, James B Rowe
Jun 11, 2020
BACKGROUND: Synaptic loss is a prominent and early feature of many neurodegenerative diseases. OBJECTIVES: We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy...
Interview with Gwen P. Howell
Gwen P. Howell
Jan 01, 0001
Interview with Gwen P. Howell, member of the South Carolina Mothers Association.
Published by: Winthrop University
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
Survey evaluating clinical equipoise around platelet transfusion after head injury and traumatic intracranial haemorrhage (ICH) in patients on antiplatelet medications.
Catherine Ashton, M Laffan, PJ Hutchinson, Fiona Lecky, S Ralhan, Jason E Smith, Jonathan P Coles, Simon Stanworth, Nicola Curry
Jun 11, 2021
INTRODUCTION: Patients aged 60 or over account for over half of the severely injured trauma patients and a traumatic brain injury is the most common injury sustained. Many of these patients are taking antiplatelet medications...
Motivations and Social Media Influencing Online Purchase Intention in India
The purpose of the study is to examine the influence of hedonic and utilitarian motivation on Indian consumer's online purchase intention. Second, this study tried to explore if social media mediates the influence of hedonic and...
Published by: IGI Global Scientific Publishing
PSK Method for Solving Mixed and Type-4 Intuitionistic Fuzzy Solid Transportation Problems
P. Kumar
Apr 01, 2019
In this article, the author categorises the solid transportation problem (STP) under uncertain environments. He formulates the mixed and fully intuitionistic fuzzy solid transportation problems (FIFSTPs) and utilizes the...
Published by: IGI Global Scientific Publishing
Characterising neuropsychiatric disorders in patients with COVID-19 - Authors' reply.
Aravinthan Varatharaj, Thomas A Pollak, Timothy R Nicholson, Jonathan P Coles, Laura A Benjamin, Alan Carson, Rhys H Thomas, Benedict D Michael, study authors
Oct 27, 2020
Language Learning Through Zoom
Jonathan White
Jan 01, 2024
Attributable to the COVID pandemic, Zoom has become one of most widely used digital tools for online interaction. Schools and universities had to transition to wholly online teaching, and Zoom was one of the platforms used for...
Published by: IGI Global Scientific Publishing
In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.
W Richard Bevan-Jones, Thomas E Cope, P Simon Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Jan 28, 2019
Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes...
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury
Jussi P Posti, Iftakher Hossain, Riikka SK Takala, Hilkka Liedes, Virginia Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzen, Henna Ala-Seppala, Jonathan P Coles, Anna Kyllonen, Henna-Riikka Maanpaa, Jussi Tallus, Peter J Hutchinson, Mark van Gils, David K Menon, Olli Tenovuo, TBIcare Investigators
Aug 16, 2017
Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) have been studied as potential
biomarkers of mild traumatic brain injury (mTBI). We report the levels of GFAP and UCH-L1 in patients with...
Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
Nicholas O. Burton, Cristian Riccio, Alexandra Dallaire, Jonathan Price, Benjamin Jenkins, Albert Koulman, Eric A. Miska
Apr 08, 2021
Abstract: Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis...
Immune reconstitution after alemtuzumab therapy for multiple sclerosis triggering Graves' orbitopathy
Jonathan CP Roos, Carla Moran, V Krishna Chatterjee, Joanne Jones, Alasdair Coles, Rachna Murthy
Dec 20, 2018
Alemtuzumab-a monoclonal antibody targeting the CD52 glycoprotein expressed by most mature leucocytes-effectively decreases relapse rate and disability progression in early, relapsing-remitting multiple sclerosis (MS). However...
Adolescent Adult Alemtuzumab Antineoplastic Agents Immunological Autoantibodies Disease Progression Enzyme-Linked Immunosorbent Assay Female Graves Ophthalmopathy Humans Immune Reconstitution Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis Receptors Thyrotropin Recurrence Retrospective Studies Risk Factors
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
Correction to
Jonathan M Lawton, Mariam Habib, Bingkui Ma, Roger A Brooks, Serena M Best, Andrew L Lewis, Neil Rushton, William Bonfield
Jun 11, 2018
The article "The effect of cationically modified phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo", written by Jonathan M. Lawton, Mariam Habib, Bingkui Ma, Roger A. Brooks...
Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection.
Nicholas O Burton, Cristian Riccio, Alexandra Dallaire, Jonathan Price, Benjamin Jenkins, Albert Koulman, Eric A Miska
May 10, 2020
Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a...
Published by: Nature Communications
[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.
Richard W Bevan-Jones, Thomas E Cope, Simon P Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin A Aigbirhio, Karalyn Patterson, John T O'Brien, James B Rowe
Nov 29, 2018
The PET ligand [18F]AV-1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP-43...
Rare Diseases Brain Disorders Dementia Acquired Cognitive Impairment aging Neurodegenerative Neurosciences Alzheimer's Disease Alzheimer's Disease Related Dementias (ADRD) Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) frontotemporal dementia (FTD) 2 Aetiology 2.1 Biological and endogenous factors Neurological
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