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Results: 14731
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Parasvi S Patel, Karan Joshua Abraham, Kiran Kumar Naidu Guturi, Marie-Jo Halaby, Zahra Khan, Luis Palomero, Brandon Ho, Shili Duan, Jonathan St-Germain, Arash Algouneh, Francesca Mateo, Samah El Ghamrasni, Haithem Barbour, Daniel R Barnes, Jonathan Beesley, Otto Sanchez, Hal K Berman, Grant W Brown, El Bachir Affar, Georgia Chenevix-Trench, Antonis C Antoniou, Cheryl H Arrowsmith, Brian Raught, Miquel Angel Pujana, Karim Mekhail, Anne Hakem, Razqallah Hakem
Feb 15, 2021
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain...
Multivariate spatio-temporal modelling for assessing Antarctica's present-day contribution to sea-level rise
Antarctica is the world's largest fresh-water reservoir, with the potential to raise sea levels by about 60m. An ice sheet contributes to sea-level rise (SLR) when its rate of ice discharge and/or surface melting exceeds...
Multivariate spatio-temporal modelling for assessing Antarctica's present-day contribution to sea-level rise
Antarctica is the world's largest fresh-water reservoir, with the potential to raise sea levels by about 60m. An ice sheet contributes to sea-level rise (SLR) when its rate of ice discharge and/or surface melting exceeds...
R/BHC
BACKGROUND: Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data analysis, little attention has been paid to uncertainty in...
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
Understanding the influences on successful quality improvement in emergency general surgery
Timothy J Stephens, Jonathan R Bamber, Ian J Beckingham, Ellie Duncan, Nial F Quiney, John F Abercrombie, Graham Martin, Chole-QuIC collaborator group
May 13, 2019
BACKGROUND: Acute gallstone disease is the highest volume Emergency General Surgical presentation in the UK. Recent data indicate wide variations in the quality of care provided across the country, with national guidance for...
Breakthrough collaborative evaluation Gallstone disease Normalisation process theory Quality Improvement service improvement Acute Disease Attitude of Health Personnel Case-Control Studies Cholecystectomy Cooperative Behavior Emergency Service hospital Gallstones Humans leadership Patient Care Team Prospective Studies Quality Improvement Time-to-Treatment United Kingdom
Alphonse R. Dochez, 1925
The Rockefeller University
Jan 01, 0001
Alphonse R. Dochez. Etiology of Scarlet Fever
Lecture delivered January 17th, 1925
Posted with permission
Published by: J.B. Lippincott Company
Florence R. Sabin, 1915
The Rockefeller University
Jan 01, 0001
Prof. Florence R. Sabin. The Method of Growth of the Lymphatic System
Lecture delivered December 18th, 1915
Published by: J.B. Lippincott Company
The CBI-R detects early behavioural impairment in genetic frontotemporal dementia.
Annabel Nelson, Lucy L Russell, Georgia Peakman, Rhian S Convery, Arabella Bouzigues, Caroline V Greaves, Martina Bocchetta, David M Cash, John C van Swieten, Lize Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Chris R Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan D Rohrer, Genetic FTD Initiative (GENFI)
Sep 10, 2022
INTRODUCTION: Behavioural dysfunction is a key feature of genetic frontotemporal dementia (FTD) but validated clinical scales measuring behaviour are lacking at present. METHODS: We assessed behaviour using the revised version...
Personality Antecedents of EWoM in Determining Online Customer Purchase Behavior
Electronic word of mouth (EWoM) is similar to the standard word of mouth- the only difference is, the use of Internet as a base in EWoM. By understanding the personality antecedents of EWoM, the consumer buyer beahviour could be...
Published by: IGI Global Scientific Publishing
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
Bayesian Spatial Modelling with R-INLA
The principles behind the interface to continuous domain spatial models in the R- INLA software package for R are described. The integrated nested Laplace approximation (INLA) approach proposed by Rue, Martino, and Chopin (2009)...
A cross-machine comparison of shear-wave speed measurements using 2d shear-wave elastography in the normal female breast
Quantitative measures of radiation-induced breast stiffness are required to support clinical studies of novel breast radiotherapy regimens and exploration of personalised therapy, however, variation between shear-wave...
Bayesian Spatial Modelling with R-INLA
The principles behind the interface to continuous domain spatial models in the R- INLA software package for R are described. The integrated nested Laplace approximation (INLA) approach proposed by Rue, Martino, and Chopin (2009)...
Language Learning Through Zoom
Jonathan White
Jan 01, 2024
Attributable to the COVID pandemic, Zoom has become one of most widely used digital tools for online interaction. Schools and universities had to transition to wholly online teaching, and Zoom was one of the platforms used for...
Published by: IGI Global Scientific Publishing
Using R and Bioconductor for proteomics data analysis.
This review presents how R, the popular statistical environment and programming language, can be used in the frame of proteomics data analysis. A short introduction to R is given, with special emphasis on some of the features...
A farewell to <i>R</i>
The time-dependent reproduction number, Rt, is a key metric used by epidemiologists to assess the current state of an outbreak of an infectious disease. This quantity is usually estimated using...
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD.
Yannick Marcon, Tom Bishop, Demetris Avraam, Xavier Escriba-Montagut, Patricia Ryser-Welch, Stuart Wheater, Paul Burton, Juan R González
Apr 09, 2021
Combined analysis of multiple, large datasets is a common objective in the health- and biosciences. Existing methods tend to require researchers to physically bring data together in one place or follow an analysis plan and share...
Explanatory Adequacy in Phonology
Eric Russell Webb
Aug 01, 2013
This work reexamines phonological variation particular to the /R/ of convergent French, departing from the hypothesis that a deductive approach to this question can offer explanatory advantages. In contrast to data-driven...
Published by: Atlantic Provinces Linguistic Association
The impact of the alkyne substitution pattern and metalation on the photo-isomerization of azobenzene-based platinum(II) diynes and polyynes
Rayya A. Al-balushi, Ashanul Haque, Maharaja Jayapal, Mohammed K. Al-Suti, John Husband, Muhammad S. Khan, Jonathan M. Skelton, Kieran C. Molloy, Paul R. Raithby
Nov 07, 2016
Trimethylsilyl-protected di-alkynes incorporating azobenzene linker groups, Me3Si─C≡C─R─C≡C─SiMe3 (R = azobenzene-3,3’-diyl, azobenzene-4,4’-diyl, 2,5-bisoctylazobenzene-4,4’-diyl), and the corresponding terminal dialkynes...
The impact of the alkyne substitution pattern and metalation on the photo-isomerization of azobenzene-based platinum(II) diynes and polyynes
Rayya A. Al-balushi, Ashanul Haque, Maharaja Jayapal, Mohammed K. Al-Suti, John Husband, Muhammad S. Khan, Jonathan M. Skelton, Kieran C. Molloy, Paul R. Raithby
Nov 07, 2016
Trimethylsilyl-protected di-alkynes incorporating azobenzene linker groups, Me3Si─C≡C─R─C≡C─SiMe3 (R = azobenzene-3,3’-diyl, azobenzene-4,4’-diyl, 2,5-bisoctylazobenzene-4,4’-diyl), and the corresponding terminal dialkynes...
Correction to
Jonathan M Lawton, Mariam Habib, Bingkui Ma, Roger A Brooks, Serena M Best, Andrew L Lewis, Neil Rushton, William Bonfield
Jun 11, 2018
The article "The effect of cationically modified phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo", written by Jonathan M. Lawton, Mariam Habib, Bingkui Ma, Roger A. Brooks...
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