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Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins.
Michael Fernandopulle, GuoZhen Wang, Jonathon Nixon-Abell, Seema Qamar, Varun Balaji, Ryuta Morihara, Peter H St George-Hyslop
Jul 08, 2019
ANXA11 Amyotrophic Lateral Sclerosis FUS TDP-43 biological condensates fronto-temporal dementia gelation Hydrogels local RNA translation neuronal transport granules phase separation Stress granules Amyotrophic Lateral Sclerosis Annexins Biological Transport DNA-Binding Proteins Frontotemporal Lobar Degeneration Humans Intracellular Membranes Mutation Missense Neurodegenerative Diseases Neurons Protein Processing Post-Translational RNA-Binding Protein FUS Temporal Lobe
Spatially non-uniform condensates emerge from dynamically arrested phase separation.
Nadia A Erkamp, Tomas Sneideris, Hannes Ausserwöger, Daoyuan Qian, Seema Qamar, Jonathon Nixon-Abell, Peter St George-Hyslop, Jeremy D Schmit, David A Weitz, Tuomas P J Knowles
Mar 13, 2023
The formation of biomolecular condensates through phase separation from proteins and nucleic acids is emerging as a spatial organisational principle used broadly by living cells. Many such biomolecular condensates are not...
Published by: Nature Communications
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Ya-Cheng Liao, Michael Fernandopulle, GuoZhen Wang, Heejun Choi, Ling Hao, Catherine M Drerup, Seema Qamar, Jonathon Nixon-Abell, Yi Shen, William Meadows, Michele Vendruscolo, Tuomas Knowles, Matthew Nelson, Magda Czekalska, Greta Musteikyte, Rajan Patel, Christina Stephens, Amalia Pasolli, Lucy Forrest, Peter St George-Hyslop, Jennifer Lippincott-Schwartz, Michael E Ward
Sep 04, 2019
Long-distance RNA transport enables local protein synthesis at metabolicallyactive
sites distant from the nucleus. This process ensures an appropriate spatial
organization of proteins, vital to polarized cells such as neurons....
ANXA11 Amyotrophic Lateral Sclerosis local translation lysosome neurodegeneration neuron Organelles contact phase separation RNA granule RNA transport Amyotrophic Lateral Sclerosis Animals Animals Genetically Modified Annexins Axonal Transport Axons Cell Line Tumor Cytoplasmic Granules Female Humans Induced Pluripotent Stem Cells Lysosomes Male Mutation Protein Binding RNA Rats Rats Sprague-Dawley Transfection Zebrafish
A Ten Billion Solar Mass Outflow of Molecular Gas Launched by Radio Bubbles in the Abell 1835 Brightest Cluster Galaxy
B. R. McNamara, H. R. Russell, P. E. J. Nulsen, A. C. Edge, N. W. Murray, R. A. Main, A. N. Vantyghem, F. Combes, A. C. Fabian, P. Salome, C. C. Kirkpatrick, S. A. Baum, J. N. Bregman, M. Donahue, E. Egami, S. Hamer, C. P. O'Dea, J. B. R. Oonk, G. Tremblay, G. M. Voit
Mar 25, 2014
We report ALMA Early Science observations of the Abell 1835 brightest cluster galaxy (BCG) in the CO (3-2) and CO (1-0) emission lines. We detect 5E10 solar masses of molecular gas within 10 kpc of the BCG. Its velocity width of...
Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state.
Joseph E Chambers, Nikita Zubkov, Markéta Kubánková, Jonathon Nixon-Abell, Ioanna Mela, Susana Abreu, Max Schwiening, Giulia Lavarda, Ismael López-Duarte, Jennifer A Dickens, Tomás Torres, Clemens F Kaminski, Liam J Holt, Edward Avezov, James A Huntington, Peter St George-Hyslop, Marina K Kuimova, Stefan J Marciniak
May 09, 2022
A Ten Billion Solar Mass Outflow of Molecular Gas Launched by Radio Bubbles in the Abell 1835 Brightest Cluster Galaxy
B. R. McNamara, H. R. Russell, P. E. J. Nulsen, A. C. Edge, N. W. Murray, R. A. Main, A. N. Vantyghem, F. Combes, A. C. Fabian, P. Salome, C. C. Kirkpatrick, S. A. Baum, J. N. Bregman, M. Donahue, E. Egami, S. Hamer, C. P. O'Dea, J. B. R. Oonk, G. Tremblay, G. M. Voit
Mar 25, 2014
We report ALMA Early Science observations of the Abell 1835 brightest cluster galaxy (BCG) in the CO (3-2) and CO (1-0) emission lines. We detect 5E10 solar masses of molecular gas within 10 kpc of the BCG. Its velocity width of...
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
William E Arter, Runzhang Qi, Nadia A Erkamp, Georg Krainer, Kieran Didi, Timothy J Welsh, Julia Acker, Jonathan Nixon-Abell, Seema Qamar, Jordina Guillén-Boixet, Titus M Franzmann, David Kuster, Anthony A Hyman, Alexander Borodavka, Peter St George-Hyslop, Simon Alberti, Tuomas PJ Knowles
Jan 22, 2023
The assembly of biomolecules into condensates is a fundamental process underlying the organisation of the intracellular space and the regulation of many cellular functions. Mapping and characterising phase behaviour of...
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
William E Arter, Runzhang Qi, Nadia A Erkamp, Georg Krainer, Kieran Didi, Timothy J Welsh, Julia Acker, Jonathan Nixon-Abell, Seema Qamar, Jordina Guillén-Boixet, Titus M Franzmann, David Kuster, Anthony A Hyman, Alexander Borodavka, Peter St George-Hyslop, Simon Alberti, Tuomas PJ Knowles
Dec 21, 2022
The Future of Cardiovascular Computed Tomography
Edward D Nicol, Bjarne L Norgaard, Philipp Blanke, Amir Ahmadi, Jonathon Weir-McCall, Pal Maurovich Horvat, Kelly Han, Jeroen J Bax, Jonathon Leipsic
Jan 10, 2020
Cardiovascular computed tomography (CCT) has undergone rapid maturation over the last decade and is now of proven clinical utility in the diagnosis and management of coronary artery disease, in guiding structural heart disease...
FFR(CT) TMVR Atherosclerosis cardiac CT Machine Learning Radiomics Computed Tomography Angiography Coronary Angiography Diffusion of Innovation Forecasting Heart Diseases Humans Models Cardiovascular Patient-Specific Modeling Predictive Value of Tests printing Three-Dimensional Prognosis Tomography Scanners X-Ray Computed
Milk microbiome in dairy cattle and the challenges of low microbial biomass and exogenous contamination.
BACKGROUND: The blanket usage of antimicrobials at the end of lactation (or "drying off") in dairy cattle is under increasing scrutiny due to concerns about antimicrobial resistance. To lower antimicrobial usage in dairy...
Biased motion-adaptive temporal filtering for speckle reduction in echocardiography
Describes a new fully motion-adaptive spatio-temporal filtering technique to reduce the speckle in ultrasound images. The advantages of this approach are demonstrated in echocardiographic boundary detection and in comparison...
Biased motion-adaptive temporal filtering for speckle reduction in echocardiography
Describes a new fully motion-adaptive spatio-temporal filtering technique to reduce the speckle in ultrasound images. The advantages of this approach are demonstrated in echocardiographic boundary detection and in comparison...
Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.
Bernhard Strauss, Andrew Harrison, Paula Almeida Coelho, Keiko Yata, Magdalena Zernicka-Goetz, Jonathon Pines
May 02, 2018
There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential...
Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).
Ana Trapero, Angela Pacitto, Daniel Shiu-Hin Chan, Chris Abell, Tom L Blundell, David B Ascher, Anthony G Coyne
Nov 15, 2019
Inosine-5'-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme involved in nucleotide biosynthesis. Because of its critical role in purine biosynthesis, IMPDH is a drug design target for immunosuppressive, anticancer...
Aura-3D
Atmospheric retrievals of exoplanet transmission spectra allow constraints on
the composition and structure of the day-night terminator region. Such
retrievals in the past have typically assumed one-dimensional...
Quarantine encounters with digital animals
Quarantine conditions led to the proliferation of digital encounters with nonhuman animals. Here, we explore three prominent forms: creaturely cameos, avatar acquaintances and background birding. These virtual encounters...
Reverse iontophoresis of L-lactate
This work investigates the reverse iontophoretic extraction of lactate, a widely used marker of tissue distress in critically ill patients and of sports performance. In vitro experiments were performed to establish the...
The Ursinus Weekly, October 10, 1960
Catherine A. Nicolai, Richard F. Levine, Gail Ford, Cynthia Morris, Kathryn Moyer O'Donnell, Frederick Bauman, Jr., Gerald Morita, Brenda Theisz
Jan 01, 0001
Noted cellist to appear here; Orlando Cole plays Oct. 12 "Touchdown 1960" a great success WAA holds meeting; To sell candy in dorms College students can cast absentee ballots SMU extends alma mater song contest one year ...
Ursinus College Collegeville Pennsylvania newspaper Philadelphia Symphonic Orchestra Women's Athletic Association Southern Methodist University Lantern Business Administration Club International Relations Commission German Club Young Republicans Dick Schweiker Beardwood Chemical Society Vernon Morgan Chi Alpha society Curtain Club student government Young Democrats Jacob Bronowski sororities rushing Richard Nixon Intramural Sports field hockey Football Canterbury Club Donald L. Helfferich cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
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