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Dependency ratios in healthy ageing
Although people are living longer, there is no discernible pattern about the quality of life in an increasing lifespan. This restricts our capacity to predict and prepare for the consequences of population ageing. Accordingly...
Dependency ratios in healthy ageing
Although people are living longer, there is no discernible pattern about the quality of life in an increasing lifespan. This restricts our capacity to predict and prepare for the consequences of population ageing. Accordingly...
The Translators' Take on Three Possible Typos in Jorge L. Borges' Story “Tlön, Uqbar, Orbis Tertius”
Marcelo Sanchez
Jan 01, 2023
This article examines how translators tackled the problem given by three possible typos in Jorge Luis Borges' short story “Tlön, Uqbar, Orbis Tertius.” Translations to all major Western languages are considered. The translators'...
Published by: IGI Global Scientific Publishing
Direct measurement of lensing amplification in Abell S1063 using a strongly lensed high redshift HII galaxy
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo JL Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Sep 15, 2020
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their...
Synthesis, conformational analysis and <i>in vivo</i> assays of an anti-cancer vaccine that features an unnatural antigen based on an sp<sup>2</sup>-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo J L Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Jul 28, 2021
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to...
Published by: Chemical science
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley, Juan Cadiñanos
Oct 27, 2020
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional...
Animals Cell Line Cell Movement DNA Transposable Elements Epithelial Cells Gene Dosage Genes Tumor Suppressor Genetic Predisposition to Disease Humans Kaplan-Meier Estimate Male Mice Knockout Mice Transgenic Mutagenesis Insertional Mutation PTEN Phosphohydrolase Prostate Prostatic Neoplasms RNA Interference Signal Transduction
Rethinking Technology-Based Services to Promote Citizen Participation in Urban Mobility
Cities are complex and dynamic systems in which a network of actors interact, creating value through different activities. Cities can, therefore, be viewed as service ecosystems. Municipalities take advantage of digitalization...
Published by: IGI Global Scientific Publishing
From JWH-018 to OXIZIDS
With new synthetic cannabinoids (SCs) appearing on the European drug market every year, early warning systems are key to detect, monitor, and respond to threats posed by them. The European Union Early Warning System (EU EWS)...
European drug market drug detection early warning system new psychoactive substances synthetic cannabinoids /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/1600/1607 name=Spectroscopy /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
OKR Methodology
In a changing world, dominated by fierce competition, it is imperative that companies have the necessary agility to adapt to the market constraints where they operate, investing in frameworks that promote the achievement of...
Published by: IGI Global Scientific Publishing
Gaining a Competitive Advantage Through Benefits Management
To gain competitive advantage, organizations need to have something that the competitors do not have and cannot achieve in the short-term. In the past, organizations invested large amounts of financial resources to the finest...
Published by: IGI Global Scientific Publishing
Defining Business Objectives Supported by Organizational Maturity and Benefits Management
Organizations today need to provide better products and services. The issues they face require integrated approaches and effective management of their resources. Maturity models help integrate traditionally separate...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.
Jorge López-Tello, Vicente Pérez-García, Jaspreet Khaira, Laura C Kusinski, Wendy N Cooper, Adam Andreani, Imogen Grant, Edurne Fernández de Liger, Brian YH Lam, Myriam Hemberger, Ionel Sandovici, Miguel Constancia, Amanda N Sferruzzi-Perri
Mar 08, 2021
Studies suggest that placental nutrient supply adapts according to fetal demands. However, signaling events underlying placental adaptations remain unknown. Here we demonstrate that phosphoinositide 3-kinase p110α in the fetus...
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.
Jorge de la Rosa, José MP Freije, Rubén Cabanillas, Fernando G Osorio, Mario F Fraga, M Soledad Fernández-García, Roland Rad, Víctor Fanjul, Alejandro P Ugalde, Qi Liang, Haydn M Prosser, Allan Bradley, Juan Cadiñanos, Carlos López-Otín
Oct 14, 2020
Defining the relationship between ageing and cancer is a crucial but challenging task. Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate...
Rethinking the Postwar Period in Spain
Jorge Marco
Jul 31, 2020
There is a consensus among scholars regarding the slow transformation of ‘hot-blooded terror’ into ‘cold-blooded terror’ during the Civil War and the Post-war period in Spain. This article challenges this framework in two ways....
Aligning Project and Benefits Management With Balanced Scorecard Approach to Achieve Project Success
The organizations have spent an increased amount of financial resources in systems and technology without getting all the potential of their investments or collecting the promise business benefits. Organizational success is...
Published by: IGI Global Scientific Publishing
From JWH-018 to OXIZIDS
With new synthetic cannabinoids (SCs) appearing on the European drug market every year, early warning systems are key to detect, monitor, and respond to threats posed by them. The European Union Early Warning System (EU EWS)...
European drug market drug detection early warning system new psychoactive substances synthetic cannabinoids /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/1600/1607 name=Spectroscopy /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Rényi Entropy in Statistical Mechanics.
Rényi entropy was originally introduced in the field of information theory as a parametric relaxation of Shannon (in physics, Boltzmann-Gibbs) entropy. This has also fuelled different attempts to generalise statistical...
To go or not to go with the flow
Jorge E. Santos
Jun 17, 2021
Abstract: We construct the gravitational dual of a one-parameter class of states of strongly coupled SU(N) N = 4 SYM at infinite N and asymptotic temperature T∞, on a fixed Schwarzschild black hole background with temperature...
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