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An Exploration of COVID-19 and Its Consideration as a Black Swan for the Construction Industry in Switzerland
COVID-19 and its devastating yet unforeseeable effects affect the entire global economy value chain. Effects will be long-lasting and interfere with the way construction worked so far. Losses in the industry are expected to run...
Published by: IGI Global Scientific Publishing
Open Source Software Adoption in the Financial Services Industry
Although OSS has gained traction across industries worldwide, few studies have been reported on OSS adoption in the financial industry and even less in the context of developing countries. This paper presents an exploratory...
Published by: IGI Global Scientific Publishing
Simple reaction time for broadband sounds compared to pure tones.
Although many studies have explored the relation between reaction time (RT) and loudness, including effects of intensity, frequency, and binaural summation, comparable work on spectral summation is rare. However, most real-world...
Application of Bayesian Active Learning to the Estimation of Auditory Filter Shapes Using the Notched-Noise Method.
Time-efficient hearing tests are important in both clinical practice and research studies. This particularly applies to notched-noise tests, which are rarely done in clinical practice because of the time required....
Increasing incidence of immune-mediated necrotizing myopathy
Martin Klein, Heřman Mann, Lenka Pleštilová, Josef Zámečník, Zoe Betteridge, Neil McHugh, Jiří Vencovský
Aug 06, 2015
OBJECTIVES: Immune-mediated necrotizing myopathy (IMNM) is characterized by the predominant presence of necrotic muscle fibres in muscle biopsy and variable response to immunosuppressive treatment. The aims of this study were...
SciPy 1.0
Pauli Virtanen, Ralf Gommers, Travis E Oliphant, Matt Haberland, Tyler Reddy, David Cournapeau, Evgeni Burovski, Pearu Peterson, Warren Weckesser, Jonathan Bright, Stéfan J van der Walt, Matthew Brett, Joshua Wilson, K Jarrod Millman, Nikolay Mayorov, Andrew RJ Nelson, Eric Jones, Robert Kern, Eric Larson, CJ Carey, İlhan Polat, Yu Feng, Eric W Moore, Jake VanderPlas, Denis Laxalde, Josef Perktold, Robert Cimrman, Ian Henriksen, EA Quintero, Charles R Harris, Anne M Archibald, Antônio H Ribeiro, Fabian Pedregosa, Paul van Mulbregt, SciPy 1.0 Contributors
Aug 02, 2021
SciPy is an open-source scientific computing library for the Python programming language. Since its initial release in 2001, SciPy has become a de facto standard for leveraging scientific algorithms in Python, with over 600...
Development of a Deep Neural Network for Speeding Up a Model of Loudness for Time-Varying Sounds
The “time-varying loudness” (TVL) model of Glasberg and Moore calculates “instantaneous loudness” every 1 ms, and this is used to generate predictions of short-term loudness, the loudness of a short segment of sound, such as a...
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
Ilias Georgakopoulos-Soares, Gene Koh, Sophie E. Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Apr 24, 2021
Abstract: The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method...
Overall judgment of loudness of time-varying sounds.
Listeners can judge the overall loudness of time-varying sounds quite easily, i.e., assign a single value that represents the loudness of the entire sound. This holds even if the duration is long and the judgment includes memory...
Political Policy Implementation Analysis Kupang City Regional Income And Expenditure Budget (Study On The Budget For Managing Covid-19 In 2021)
The issue of COVID-19 has affected the economy and society of the country. So the government is taking various steps to prevent it by pushing laws of isolation and quarantine, as well as enforcing restrictions and community...
Published by: Indonesia Strategic Sustainability
A Hearing-Model-Based Active-Learning Test for the Determination of Dead Regions.
This article describes a Bayesian active-learning procedure for estimating the edge frequency, fe, of a dead region, that is, a region in the cochlea with no or very few functioning inner hair cells or neurons. The method is...
Increasing incidence of immune-mediated necrotizing myopathy
Martin Klein, Heřman Mann, Lenka Pleštilová, Josef Zámečník, Zoe Betteridge, Neil McHugh, Jiří Vencovský
Aug 06, 2015
OBJECTIVES: Immune-mediated necrotizing myopathy (IMNM) is characterized by the predominant presence of necrotic muscle fibres in muscle biopsy and variable response to immunosuppressive treatment. The aims of this study were...
3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action
Josef Köhrle, Ina Lehmphul, Maik Pietzner, Kostja Renko, Eddy Rijntjes, Keith Richards, João Anselmo, Mark Danielsen, Jacqueline Jonklaas
Jan 22, 2020
Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods....
In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells.
Laura Ostermann, Julia Ladewig, Franz-Josef Müller, Jaideep Kesavan, Jignesh Tailor, Austin Smith, Oliver Brüstle, Philipp Koch
Aug 21, 2019
During nervous system development, early neuroepithelial stem (NES) cells with a highly polarized morphology and responsiveness to regionalizing morphogens give rise to radial glia (RG) cells, which generate region-specific...
Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification.
Josef Wagner, Paul Coupland, Hilary P Browne, Trevor D Lawley, Suzanna C Francis, Julian Parkhill
Sep 06, 2019
BACKGROUND: Currently, bacterial 16S rRNA gene analyses are based on sequencing of individual variable regions of the 16S rRNA gene (Kozich, et al Appl Environ Microbiol 79:5112-5120, 2013).This short read approach can introduce...
Capillary sequencing Full-length bacterial 16S rRNA gene sequencing MiSeq sequencing PacBio sequencing Base Sequence Biodiversity Computational Biology DNA Bacterial DNA Ribosomal Female genetic variation High-Throughput Nucleotide Sequencing Humans Metagenome Microbiota Phylogeny RNA Ribosomal 16S Sequence Analysis DNA Staphylococcus aureus Vagina
Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response.
Evgeniya Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton Enright, Andrew J Macpherson, Brian Ferguson, Geoffrey Smith
Apr 21, 2022
Interactions between pathogens, host microbiota and the immune system influence many physiological and pathological processes. In the 20th century, widespread dermal vaccination with vaccinia virus (VACV) led to the eradication...
A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke.
Alexandra Lucaciu, Hannah Kuhn, Sandra Trautmann, Nerea Ferreirós, Helmuth Steinmetz, Josef Pfeilschifter, Robert Brunkhorst, Waltraud Pfeilschifter, Julien Subburayalu, Rajkumar Vutukuri
Aug 29, 2020
Emerging evidence suggests a complex relationship between sphingosine 1-phosphate (S1P) signaling and stroke. Here, we show the kinetics of S1P in the acute phase of ischemic stroke and highlight accompanying changes in immune...
Ceramides fingolimod regulatory T helper cells sphingosine 1-phosphate sphingosine 1-phosphate receptor sphingosine kinase stroke Animals Brain Disease Models Animal ischemic stroke Lysophospholipids Male Mice Mice Inbred C57BL Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory
The S1P-S1PR Axis in Neurological Disorders-Insights into Current and Future Therapeutic Perspectives.
Alexandra Lucaciu, Robert Brunkhorst, Josef M Pfeilschifter, Waltraud Pfeilschifter, Julien Subburayalu
Jun 23, 2020
Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena. Studies have highlighted its importance regarding intracellular signaling...
S1P1–5 fingolimod Multiple Sclerosis neurodegeneration sphingosine 1-phoshate sphingosine 1-phosphate antagonistst/inhibitors sphingosine 1-phosphate metabolism sphingosine 1-phosphate receptor sphingosine 1-phosphate signaling stroke Humans Lysophospholipids Nervous System Diseases Signal Transduction Sphingosine
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts.
Ilias Georgakopoulos-Soares, Gene Koh, Sophie E Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Mar 31, 2020
Amino Acid Motifs Computational Biology DNA Breaks Double-Stranded DNA Mutational Analysis DNA Repair DNA Replication Gene Deletion Gene Expression Regulation Neoplastic genetic variation Genome Human Genomics Humans INDEL Mutation Mutagenesis Neoplasms Polynucleotides Repetitive Sequences Nucleic Acid Sequence Analysis RNA Transcription Genetic
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