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Problem formulation for theorizing at the frontier
Ostensibly, the evolving science of strategic management is geared towards addressing vexing
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
Problem formulation for theorizing at the frontier
Ostensibly, the evolving science of strategic management is geared towards addressing vexing
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
After Joseph Needham
We all owe Joseph Needham an immense debt for discovering Chinese science and technology for Western scholars. But his famous question (Why did the Chinese, who had been so far in advance of Europe until the 17th...
Geoffrey Lloyd
Jun 27, 2020
Some Reflections on Joseph Needham's Intellectual Heritage.
Jianjun Mei
Apr 03, 2020
In this essay, I reflect on Joseph Needham's intellectual heritage, its impact on understanding the world history of knowledge circulation, and its broad influence on generations of scholars. I present two case studies of...
Mature dendritic cells boost functionally superior CD8+ T-cell in humans without foreign helper epitopes
We have recently shown that a single injection of mature, antigen- pulsed, human dendritic cells (DCs) rapidly elicits CD4+ and CD8+ T-cell immunity in vivo. The DCs were pulsed with 2 foreign proteins, keyhole limpet hemocyanin...
CD8 antigen cytotoxic T lymphocy tedendritic cell Immunization helper cell T lymphocyte subpopulation
Published by: Rockefeller University
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Extracting and re-using research data from chemistry e-theses
Peter Morgan, Jim Downing, Peter Murray-Rust, Diana Stewart, Alan Tonge, Joseph A Townsend, Matt Harvey, Henry S Rzepa
Feb 14, 2011
Scientific e-theses are data-rich resources, but much of the information they contain is not readily accessible. For chemistry, the SPECTRa-T project has addressed this problem by developing data-mining techniques to extract...
Natural selection rules
We derive new effective field theory (EFT) positivity bounds on the elastic
$2\to2$ scattering amplitudes of massive spinning particles from the standard
UV properties of unitarity, causality, locality and Lorentz invariance....
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
Immunostimulatory properties of dendritic cells (DCs) are linked to their maturation state. Injection of mature DCs rapidly enhances antigen-specific CD4+ and CD8+ T cell immunity in humans. Here we describe the immune response...
cytokine production dendritic cell immunological tolerance Major Histocompatibility Complex T lymphocyte
Published by: Rockefeller University
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Leo Swadling, Mariana O Diniz, Nathalie M Schmidt, Oliver E Amin, Aneesh Chandran, Emily Shaw, Corinna Pade, Joseph M Gibbons, Nina Le Bert, Anthony T Tan, Anna Jeffery-Smith, Cedric CS Tan, Christine YL Tham, Stephanie Kucykowicz, Gloryanne Aidoo-Micah, Joshua Rosenheim, Jessica Davies, Marina Johnson, Melanie P Jensen, George Joy, Laura E McCoy, Ana M Valdes, Benjamin M Chain, David Goldblatt, Daniel M Altmann, Rosemary J Boyton, Charlotte Manisty, Thomas A Treibel, James C Moon, COVIDsortium Investigators, Lucy van Dorp, Francois Balloux, Áine McKnight, Mahdad Noursadeghi, Antonio Bertoletti, Mala K Maini
Jan 28, 2022
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before...
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Leo Swadling, Mariana O Diniz, Nathalie M Schmidt, Oliver E Amin, Aneesh Chandran, Emily Shaw, Corinna Pade, Joseph M Gibbons, Nina Le Bert, Anthony T Tan, Anna Jeffery-Smith, Cedric CS Tan, Christine YL Tham, Stephanie Kucykowicz, Gloryanne Aidoo-Micah, Joshua Rosenheim, Jessica Davies, Marina Johnson, Melanie P Jensen, George Joy, Laura E McCoy, Ana M Valdes, Benjamin M Chain, David Goldblatt, Daniel M Altmann, Rosemary J Boyton, Charlotte Manisty, Thomas A Treibel, James C Moon, COVIDsortium Investigators, Lucy van Dorp, Francois Balloux, Áine McKnight, Mahdad Noursadeghi, Antonio Bertoletti, Mala K Maini
Jan 10, 2022
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
Review of John Haugeland, Dasein Disclosed: John Haugeland’s Heidegger. Ed. Joseph Rouse. Cambridge, Massachusetts
Emily-Jean Gallant
Jan 04, 2019
John Haugeland passed away suddenly in 2010 leaving behind an unfinished book manuscript on Heidegger. He was an analytic philosopher who specialized in the philosophy of mind and cognitive science; however, he had an “extensive...
Published by: Memorial University of Newfoundland
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
Does Race Influence Executive Compensation in Chinese Firms?
Elizabeth Mahoney
Jan 01, 0001
In this study, we considered the effects of Chinese cultural and political influences on executive compensation in Chinese firms. The chief focus of this study is on whether the race of executives or the racial composition of...
Financial Performance race Executive Compensation Corporate governance China merit agency theory Chinese Communist Party CEOs compensation committees Benefits and Compensation Business Chinese Studies Performance management
Published by: Ursinus College
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
Review of John Haugeland, Dasein Disclosed: John Haugeland’s Heidegger. Ed. Joseph Rouse. Cambridge, Massachusetts
Emily-Jean Gallant
Jan 04, 2019
John Haugeland passed away suddenly in 2010 leaving behind an unfinished book manuscript on Heidegger. He was an analytic philosopher who specialized in the philosophy of mind and cognitive science; however, he had an “extensive...
Published by: Memorial University of Newfoundland
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