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Results: 251
Body mass index, prudent diet score and social class across three generations
Sarah Carter, Camille Parsons, Kate Ward, Michael Clynes, Elaine M Dennison, Cyrus Cooper
Jan 11, 2021
Background: Studies describing body mass index (BMI) and prudent diet score have reported that they are associated between parents and children. The Hertfordshire Intergenerational Study, which contains BMI, diet and social...
Published by: BMJ Publishing Group
Body mass index, prudent diet score and social class across three generations
Sarah Carter, Camille Parsons, Kate Ward, Michael Clynes, Elaine M Dennison, Cyrus Cooper
Aug 26, 2021
BACKGROUND: Studies describing body mass index (BMI) and prudent diet score have reported that they are associated between parents and children. The Hertfordshire Intergenerational Study, which contains BMI, diet and social...
Mitochondrial dynamics
Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and size. Their transient and rapid...
Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling
Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this family is known to control the mitochondrial outer membrane permeabilization (MOMP): a central step in the mitochondrial pathway of...
De-fusing mitochondria defuses the mtDNA time-bomb.
Being uniparentally inherited and with a high mutation rate, mitochondrial DNA (mtDNA) should relentlessly acquire mutations, eventually destroying a species through “mutational meltdown”. Lieber et al. now show that...
A free boundary problem arising from branching Brownian motion with selection
We study a free boundary problem for a parabolic partial differential equation in which the solution is coupled to the moving boundary through an integral constraint. The problem arises as the hydrodynamic limit of an...
Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration.
Hope I Needs, Margherita Protasoni, Jeremy M Henley, Julien Prudent, Ian Collinson, Gonçalo C Pereira
Jul 26, 2021
The fact that >99% of mitochondrial proteins are encoded by the nuclear genome and synthesised in the cytosol renders the process of mitochondrial protein import fundamental for normal organelle physiology. In addition to this...
A free boundary problem arising from branching Brownian motion with selection
We study a free boundary problem for a parabolic partial differential equation in which the solution is coupled to the moving boundary through an integral constraint. The problem arises as the hydrodynamic limit of an...
The Complex Dance of Organelles during Mitochondrial Division.
Mitochondria are dynamic organelles that undergo cycles of fission and fusion events depending on cellular requirements. During mitochondrial division, the GTPase dynamin-related protein-1 is recruited to endoplasmic reticulum...
Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling
Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this family is known to control the mitochondrial outer membrane permeabilization (MOMP): a central step in the mitochondrial pathway of...
Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration
Hope I. Needs, Margherita Protasoni, Jeremy M. Henley, Julien Prudent, Ian Collinson, Gonçalo C. Pereira
May 20, 2021
The fact that >99% of mitochondrial proteins are encoded by the nuclear genome and synthesised in the cytosol renders the process of mitochondrial protein import fundamental for normal organelle physiology. In addition to this...
A latex agglutination assay to quantify the amount of hemagglutinin protein in adjuvanted low-dose influenza monovalent vaccines.
Sophie Buffin, Nabila Ikhelef, Julien Prudent, Joseline Dubayle, Nolwenn Nougarede, Marie-Pierre Varenne, Catherine Moste, Isabelle Legastelois
Mar 22, 2018
To formulate inactivated influenza vaccines, the concentration of hemagglutinin (HA) must be accurately determined. The standard test currently used to measure HA in influenza vaccines is the Single Radial Immunodiffusion (SRID)...
Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ42 toxicity.
Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth
Aug 14, 2022
Mitochondria-ER contact sites (MERCs) orchestrate many important cellular functions including regulating mitochondrial quality control through mitophagy and mediating mitochondrial calcium uptake. Here, we identify and...
Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro.
Mikael G Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F Chinnery
Jun 17, 2021
Most humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1-2% of molecules, but rapid percentage shifts occur over one generation leading to severe mitochondrial diseases. A decrease in the...
Published by: Communications biology
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology
Olivier Lurette, Hala Guedouari, Jordan L. Morris, Rebeca Martín-Jiménez, Julie-Pier Robichaud, Geneviève Hamel-Côté, Mehtab Khan, Nicholas Dauphinee, Nicolas Pichaud, Julien Prudent, Etienne Hebert-Chatelain
Jun 29, 2022
Abstract: The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during...
Mitochondrial translation is required for sustained killing by cytotoxic T cells.
Miriam Lisci, Philippa R Barton, Lyra O Randzavola, Claire Y Ma, Julia M Marchingo, Doreen A Cantrell, Vincent Paupe, Julien Prudent, Jane C Stinchcombe, Gillian M Griffiths
Oct 18, 2021
T cell receptor activation of naïve CD8+ T lymphocytes initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells. Although CTLs show an increased reliance on...
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Olivier Lurette, Hala Guedouari, Jordan L Morris, Rebeca Martín-Jiménez, Julie-Pier Robichaud, Geneviève Hamel-Côté, Mehtab Khan, Nicholas Dauphinee, Nicolas Pichaud, Julien Prudent, Etienne Hebert-Chatelain
Jul 01, 2022
The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress....
Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
Mikael G. Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F. Chinnery
May 20, 2021
Abstract: Most humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1–2% of molecules, but rapid percentage shifts occur over one generation leading to severe mitochondrial diseases. A decrease in...
Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro.
Mikael G Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F Chinnery
Apr 01, 2021
Most humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1-2% of molecules, but rapid percentage shifts occur over one generation leading to severe mitochondrial diseases. A decrease in the...
NICHOLSON LECTURE
The Rockefeller University
Jan 01, 0001
Julien R. Zierath, Ph.D.
Molecular Mechanism for the Health-promoting Effects of Exercise: Why Muscle Matters!
Published by: The Rockefeller University
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.
Lisa Tilokani, Fiona M Russell, Stevie Hamilton, Daniel M Virga, Mayuko Segawa, Vincent Paupe, Anja V Gruszczyk, Margherita Protasoni, Luis-Carlos Tabara, Mark Johnson, Hanish Anand, Michael P Murphy, D Grahame Hardie, Franck Polleux, Julien Prudent
Dec 12, 2022
Mitochondria are dynamic organelles that undergo membrane remodeling events in response to metabolic alterations to generate an adequate mitochondrial network. Here, we investigated the function of mitochondrial fission...
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Olivier Lurette, Hala Guedouari, Jordan L Morris, Rebeca Martín-Jiménez, Julie-Pier Robichaud, Geneviève Hamel-Côté, Mehtab Khan, Nicholas Dauphinee, Nicolas Pichaud, Julien Prudent, Etienne Hebert-Chatelain
Jun 07, 2022
The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress....
Asset Liquidity and Indivisibility
We study asset liquidity in a search-theoretic framework where divisible assets can facilitate exchange for an indivisible consumption good. The distinctive characteristics of our theory are that the asset dividend can be either...
Asset Liquidity and Indivisibility
We study asset liquidity in a search-theoretic framework where divisible assets can facilitate exchange for an indivisible consumption good. The distinctive characteristics of our theory are that the asset dividend can be either...
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