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Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Impulsivity and craving in subjects with opioid use disorder on methadone maintenance treatment.
Jun Li, Kathrin Weidacker, Alekhya Mandali, Yingying Zhang, Seb Whiteford, Qihuan Ren, Zhirong Zhou, Huijing Zhou, Haifeng Jiang, Jiang Du, Chencheng Zhang, Bomin Sun, Valerie Voon
Dec 01, 2020
BACKGROUND: Methadone maintenance treatment (MMT) is effective in decreasing opioid use or facilitating abstinence. Previous studies using small opioid use disorder samples suggest that cognitive impairments including...
An M-Learning Model in the Context of the Blended Synchronous Learning Environment
Mobile learning provides more flexibility and holds considerable promise for improving the learning process and promoting lifelong learning. In order to reduce the sense of isolation felt by the learners, this research...
Published by: IGI Global Scientific Publishing
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Responses and sensitivities of maize phenology to climate change from 1971 to 2020 in Henan Province, China.
Climate change affects many aspects of the physiological and biochemical processes of growing maize and ultimately its yield. A comprehensive climate suitability model is proposed that quantifies the effects of temperature...
Responses and sensitivities of maize phenology to climate change from 1971 to 2020 in Henan Province, China.
Climate change affects many aspects of the physiological and biochemical processes of growing maize and ultimately its yield. A comprehensive climate suitability model is proposed that quantifies the effects of temperature...
Resonant Raman spectroscopy of twisted multilayer graphene.
Jiang-Bin Wu, Xin Zhang, Mari Ijäs, Wen-Peng Han, Xiao-Fen Qiao, Xiao-Li Li, De-Sheng Jiang, Andrea C Ferrari, Ping-Heng Tan
Sep 05, 2018
Graphene and other two-dimensional crystals can be combined to form various hybrids and heterostructures, creating materials on demand with properties determined by the interlayer interaction. This is the case even for a single...
Measuring gravity wave parameters from a nighttime satellite low-light image based on two-dimensional stockwell transform
Atmospheric gravity waves are a kind of mesoscale disturbance, commonly found in the atmospheric system, that plays a key role in a series of mesospheric dynamic processes. When propagating to the upper atmosphere, the...
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures
Jiao Li, Jakob Seidlitz, John Suckling, Feiyang Fan, Gong-Jun Ji, Yao Meng, Siqi Yang, Kai Wang, Jiang Qiu, Huafu Chen, Wei Liao
Mar 12, 2021
Abstract: Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene...
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures.
Jiao Li, Jakob Seidlitz, John Suckling, Feiyang Fan, Gong-Jun Ji, Yao Meng, Siqi Yang, Kai Wang, Jiang Qiu, Huafu Chen, Wei Liao
Mar 18, 2021
Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene expression...
Template-based Synthesis of a Formate Metal-Organic Framework/Activated Carbon Fiber Composite for High-performance Methane Adsorptive Separation.
Xiao-Wei Liu, Jiang-Liang Hu, Tian-Jun Sun, Ya Guo, Thomas D Bennett, Xin-Yu Ren, Shu-Dong Wang
Nov 08, 2016
Measuring gravity wave parameters from a nighttime satellite low-light image based on two-dimensional stockwell transform
Atmospheric gravity waves are a kind of mesoscale disturbance, commonly found in the atmospheric system, that plays a key role in a series of mesospheric dynamic processes. When propagating to the upper atmosphere, the...
ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
Haibin Jiang, Mingxia Du, Yaning Li, Tengfei Zhou, Jia Lei, Hongqing Liang, Zhen Zhong, Rafia S Al-Lamki, Ming Jiang, Jun Yang
Jul 15, 2022
Inhibition of DNA binding proteins 1 and 3 (ID1 and ID3) are important downstream targets of BMP signalling that are necessary for embryonic development. However, their specific roles in regulating the pluripotency of human...
Hexagonal boron nitride nanosheets doped pyroelectric ceramic composite for high-performance thermal energy harvesting
Qingping Wang, Chris R. Bowen, Rhodri Lewis, Jun Chen, Wen Lei, Haibo Zhang, Ming Yu Li, Shenglin Jiang
Jun 30, 2019
Recently, recycling energy from wasted heat with pyroelectric materials has received significant attention. However, pyroelectric energy harvesters generally suffer from a low energy efficiency due to the low rates of heat...
hexagonal boron nitride Pyroelectric ceramic Thermal conductivity Thermal energy harvesting /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Hexagonal boron nitride nanosheets doped pyroelectric ceramic composite for high-performance thermal energy harvesting
Qingping Wang, Chris R. Bowen, Rhodri Lewis, Jun Chen, Wen Lei, Haibo Zhang, Ming Yu Li, Shenglin Jiang
Jun 30, 2019
Recently, recycling energy from wasted heat with pyroelectric materials has received significant attention. However, pyroelectric energy harvesters generally suffer from a low energy efficiency due to the low rates of heat...
hexagonal boron nitride Pyroelectric ceramic Thermal conductivity Thermal energy harvesting /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
Activation and Monitoring of mtDNA Damage in Cancer Cells via the "proton-Triggered" Decomposition of an Ultrathin Nanosheet
Jun W. Liu, Yong G. Yang, Kui Wang, Ge Wang, Cong C. Shen, Yue H. Chen, Yu F. Liu, Tony D. James, Kai Jiang, Hua Zhang
Jan 27, 2021
Mitochondrial DNA (mtDNA) damage is a very important molecular event, which has significant effects on living organisms. Therefore, a particularly important challenge for biomaterials research is to develop functionalized...
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
Activation and Monitoring of mtDNA Damage in Cancer Cells via the "proton-Triggered" Decomposition of an Ultrathin Nanosheet
Jun W. Liu, Yong G. Yang, Kui Wang, Ge Wang, Cong C. Shen, Yue H. Chen, Yu F. Liu, Tony D. James, Kai Jiang, Hua Zhang
Jan 27, 2021
Mitochondrial DNA (mtDNA) damage is a very important molecular event, which has significant effects on living organisms. Therefore, a particularly important challenge for biomaterials research is to develop functionalized...
Dispersion retrieval from multi-level ultra-deep reactive-ion-etched microstructures for terahertz slow-wave circuits
Closed-loop chemical recycling of cross-linked polymeric materials based on reversible amidation chemistry.
Closed-loop chemical recycling provides a solution to the end-of-use problem of synthetic polymers. However, it remains a major challenge to design dynamic bonds, capable of effective bonding and reversible cleaving, for...
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