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Cover Image for SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer. View Article
SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer.
Iswarya Ramu, Sören M Buchholz, Melanie S Patzak, Robert G Goetze, Shiv K Singh, Frances M Richards, Duncan I Jodrell, Bence Sipos, Philipp Ströbel, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse
Oct 29, 2019
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterised by extensive matrix deposition that has been implicated in impaired drug delivery and therapeutic resistance. Secreted protein acidic and rich in cysteine...
chemoresistance Collagen Drug delivery pancreatic cancer SPARC Animals Antimetabolites Antineoplastic Cell Line Tumor Collagen Deoxycytidine Disease Models Animal Disease Progression Gene Expression Regulation Neoplastic Humans Mice Mice Transgenic Osteonectin Pancreatic Neoplasms Gemcitabine
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Cover Image for IL-21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration. View Article
IL-21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration.
Kejing Wang, Shuang Wen, Jiao Jiao, Tingting Tang, Xin ZHAO, Min Zhang, Bingjie Lv, Yuzhi Lu, Xingdi Zhou, Jingyong Li, Shaofang Nie, Yuhua Liao, Qing Wang, Xin Tu, Ziad Mallat, Ni Xia, Xiang Cheng
Mar 25, 2019
BACKGROUND AND PURPOSE: The immune system plays an important role in driving the acute inflammatory response following myocardial ischaemia/reperfusion injury (MIRI). IL-21 is a pleiotropic cytokine with multiple...
Animals Cell Movement Cells Cultured Chemokine CXCL1 Chemokine CXCL2 FIBROBLASTS Interleukins Male Mice Inbred C57BL Myocardial Reperfusion Injury Myocytes Cardiac Neutrophils Receptors Interleukin-21 Troponin T
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Cover Image for The Tidal Disruption Event AT2021ehb View Article
The Tidal Disruption Event AT2021ehb
Y Yao, W Lu, M Guolo, DR Pasham, S Gezari, M Gilfanov, KC Gendreau, F Harrison, SB Cenko, SR Kulkarni, JM Miller, DJ Walton, JA García, SV Velzen, KD Alexander, JCA Miller-Jones, M Nicholl, E Hammerstein, P Medvedev, D Stern, V Ravi, R Sunyaev, JS Bloom, MJ Graham, EC Kool, AA Mahabal, FJ Masci, J Purdum, B Rusholme, Y Sharma, R Smith, J Sollerman
Sep 15, 2022
Abstract We present X-ray, UV, optical, and radio observations of the nearby (≈78 Mpc) tidal disruption event AT2021ehb/ZTF21aanxhjv during its first 430 days of evolution....
330 High-Energy Phenomena and Fundamental Physics
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Cover Image for Artificial ageing of glass with sand abrasion View Article
Artificial ageing of glass with sand abrasion
KC Datsiou, M Overend
May 29, 2017
artificially aged glass naturally aged glass falling abrasive/sand trickling method erosive resistance of glass glass strength long term mechanical performance of glass
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Cover Image for Vaccine uptake in the Irish Travelling community View Article
Vaccine uptake in the Irish Travelling community
KC Dixon, R Mullis, T Blumenfeld
Sep 09, 2016
Ethnicity Immunization PRIMARY CARE Adolescent Child Child Preschool Healthcare Disparities Humans Infant Infant Newborn Ireland Medical Audit Roma Vaccination Vaccination Coverage
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Cover Image for Wild psychometrics View Article
Wild psychometrics
RC Shaw, NJ Boogert, NS Clayton, KC Burns
Dec 22, 2015
cognitive test battery g general intelligence factor individual variation Petroica longipes
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Cover Image for Aerotaxis in the closest relatives of animals View Article
Aerotaxis in the closest relatives of animals
JB Kirkegaard, A Bouillant, AO Marron, KC Leptos, RE Goldstein
Jan 05, 2017
$\textit{S. rosetta}$ aerotaxis biophysics choanoflagellates structural biology
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Cover Image for A rapid method to map mutations in Drosophila. View Article
A rapid method to map mutations in Drosophila.
SG Martin, KC Dobi, D St Johnston
Jun 17, 2011
Animals Chromosome Mapping Crosses Genetic Drosophila melanogaster Female Genes Insect Male Mutation Polymorphism Single Nucleotide
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Cover Image for Rayleigh instability of confined vortex droplets in critical superconductors View Article
Rayleigh instability of confined vortex droplets in critical superconductors
Igor Lukyanchuk, Valerie Vinokur, Andreas Rydh, R Xie, Milorad Milosevic, Ulrich Welp, M Zach, Z L Xiao, George Crabtree, Simon Bending, Francois Peeters, Wai-Kwong Kwok
Jan 01, 2015
Depending on the Ginzburg–Landau parameter K, superconductors can either be fully diamagnetic if K<1/SQRT(2) (type I superconductors) or allow magnetic flux to penetrate through Abrikosov vortices if K>1/SQRT(2) (type II...
Critical superconductors Mesoscopic Superconductivity Hall magnetometry
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Cover Image for Eye movements reveal a dissociation between memory encoding and retrieval in adults with autism View Article
Eye movements reveal a dissociation between memory encoding and retrieval in adults with autism
RA Cooper, KC Plaisted-Grant, S Baron-Cohen, JS Simons
Feb 20, 2017
autism eye-tracking Attention recollection encoding
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Cover Image for Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism View Article
Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism
RA Cooper, FR Richter, PM Bays, KC Plaisted-Grant, S Baron-Cohen, JS Simons
Mar 13, 2017
autism fronto-parietal control network Connectivity Hippocampus memory retrieval
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Cover Image for Rayleigh instability of confined vortex droplets in critical superconductors View Article
Rayleigh instability of confined vortex droplets in critical superconductors
Igor Lukyanchuk, Valerie Vinokur, Andreas Rydh, R Xie, Milorad Milosevic, Ulrich Welp, M Zach, Z L Xiao, George Crabtree, Simon Bending, Francois Peeters, Wai-Kwong Kwok
Jan 01, 2015
Depending on the Ginzburg–Landau parameter K, superconductors can either be fully diamagnetic if K<1/SQRT(2) (type I superconductors) or allow magnetic flux to penetrate through Abrikosov vortices if K>1/SQRT(2) (type II...
Critical superconductors Mesoscopic Superconductivity Hall magnetometry
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Cover Image for Cell size and growth regulation in the $\textit{Arabidopsis thaliana}$ apical stem cell niche View Article
Cell size and growth regulation in the $\textit{Arabidopsis thaliana}$ apical stem cell niche
L Willis, Y Refahi, R Wightman, B Landrein, J Teles, KC Huang, EM Meyerowitz, H Jönsson
Jan 30, 2017
Cell Cycle cell growth Cell Size Homeostasis plant stem cells
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Cover Image for Enhancing photoluminescence yields in lead halide perovskites by photon recycling and light out-coupling View Article
Enhancing photoluminescence yields in lead halide perovskites by photon recycling and light out-coupling
JM Richter, M Abdi-Jalebi, A Sadhanala, M Tabachnyk, JPH Rivett, LM Pazos-Outón, KC Gödel, M Price, F Deschler, RH Friend
Feb 13, 2017
0912 Materials Engineering
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Cover Image for HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer View Article
HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer
Margaret A Stanley, David M Winder, Jane C Sterling, Peter KC Goon
Nov 04, 2012
Anus Neoplasms Carcinoma in Situ Disease Progression Female Humans Incidence Male Papillomavirus Infections
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Cover Image for Thromboembolic Risk in Hospitalized and Nonhospitalized COVID-19 Patients View Article
Thromboembolic Risk in Hospitalized and Nonhospitalized COVID-19 Patients
Frederick K Ho, Kenneth KC Man, Mark Toshner, Colin Church, Carlos Celis-Morales, Ian CK Wong, Colin Berry, Naveed Sattar, Jill P Pell
Nov 25, 2021
OBJECTIVE: To assess the associations between coronavirus disease 2019 (COVID-19) infection and thromboembolism including myocardial infarction (MI), ischemic stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE)....
Aged covid-19 Case-Control Studies Hospitalization Humans Male Middle Aged pulmonary embolism Risk Factors Scotland Thromboembolism
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Cover Image for A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma. View Article
A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma.
N Bolli, Y Li, V Sathiaseelan, K Raine, D Jones, P Ganly, F Cocito, G Bignell, MA Chapman, AS Sperling, KC Anderson, H Avet-Loiseau, S Minvielle, PJ Campbell, NC Munshi
Nov 22, 2018
Genomic lesions are not investigated during routine diagnostic workup for multiple myeloma (MM). Cytogenetic studies are performed to assess prognosis but with limited impact on therapeutic decisions. Recently, several...
Alleles Cell Line Tumor DNA Copy Number Variations Gene Frequency Gene Rearrangement B-Lymphocyte Heavy Chain High-Throughput Nucleotide Sequencing Humans Immunoglobulin Heavy Chains Loss of Heterozygosity multiple myeloma Mutation Reproducibility of Results Translocation Genetic
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Cover Image for Detection of specific HPV subtypes responsible for the pathogenesis of condylomata acuminata. View Article
Detection of specific HPV subtypes responsible for the pathogenesis of condylomata acuminata.
Matthew G Hawkins, David M Winder, Siolian LR Ball, Katie Vaughan, Christopher Sonnex, Margaret A Stanley, Jane C Sterling, Peter KC Goon
May 20, 2013
Coinfection Condylomata Acuminata DNA Viral Female Gene Expression Profiling Genotype Humans Papillomaviridae Papillomavirus Infections RNA Viral Real-Time Polymerase Chain Reaction United Kingdom Viral Load
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Cover Image for Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS) View Article
Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS)
G Bellingan, F Jacono, J Bannard-Smith, D Brealey, N Meyer, D Thickett, D Young, A Bentley, BJ McVerry, RG Wunderink, KC Doerschug, C Summers, M Rojas, A Ting, ED Jenkins
Jan 10, 2022
Acute respiratory distress syndrome (ARDS) Multipotent Adult Progenitor Cells (Mapc) Stem Cells Adult Double-Blind Method Humans Intensive Care Units Quality of life Respiratory Distress Syndrome Stem Cells Treatment Outcome
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Cover Image for In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal View Article
In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal
CD Shaw, J Lonchamp, T Downing, H Imamura, TM Freeman, JA Cotton, M Sanders, G Blackburn, JC Dujardin, S Rijal, B Khanal, CJR Illingworth, GH Coombs, KC Carter
Dec 01, 2015
Animals Antimony Antiprotozoal Agents Drug Resistance Female Leishmania donovani Leishmaniasis Visceral Lipid Metabolism Membrane Transport Proteins Mice Mice Inbred BALB C Mutation Nepal Parasitic Sensitivity Tests Phosphorylcholine
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Cover Image for High Open-Circuit Voltages in Tin-Rich Low-Bandgap Perovskite-Based Planar Heterojunction Photovoltaics View Article
High Open-Circuit Voltages in Tin-Rich Low-Bandgap Perovskite-Based Planar Heterojunction Photovoltaics
B Zhao, M Abdi-Jalebi, M Tabachnyk, H Glass, VS Kamboj, WA Nie, J Pearson, Y Puttisong, KC Gödel, HE Beere, DA Ritchie, AD Mohite, SE Dutton, RH Friend, A Sadhanala
Dec 01, 2016
high mobility perovskites lead–tin perovskite PV low-bandgap perovskites Urbach energy
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Cover Image for A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster. View Article
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster.
Zhihao Zheng, J Scott Lauritzen, Eric Perlman, Camenzind G Robinson, Matthew Nichols, Daniel Milkie, Omar Torrens, John Price, Corey B Fisher, Nadiya Sharifi, Steven A Calle-Schuler, Lucia Kmecova, Iqbal J Ali, Bill Karsh, Eric T Trautman, John A Bogovic, Philipp Hanslovsky, Gregory SXE Jefferis, Michael Kazhdan, Khaled Khairy, Stephan Saalfeld, Richard D Fetter, Davi D Bock
Feb 07, 2019
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only electron microscopy (EM) enables complete...
Drosophila melanogaster connectomics Electron microscopy image stitching mushroom body neural circuits olfaction Animals Brain Brain Mapping Connectome Dendrites Drosophila melanogaster Female Microscopy Electron Mushroom Bodies Nerve Net Neurons Smell Software
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Cover Image for A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing. View Article
A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.
Georgina KC Dowsett, Brian YH Lam, John A Tadross, Irene Cimino, Debra Rimmington, Anthony P Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles SH Yeo
Apr 26, 2021
Area postrema Gene Expression Nucleus tractus solitarius obesity therapeutics Animals Area Postrema Eating Fasting Feeding Behavior Mice Mice Inbred C57BL Neurons Proprotein Convertase 1 Proprotein Convertase 2 Rhombencephalon Sequence Analysis RNA Solitary Nucleus
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Cover Image for Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection View Article
Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection
D Eletto, SO Burns, I Angulo, V Plagnol, KC Gilmour, F Henriquez, J Curtis, M Gaspar, K Nowak, V Daza-Cajigal, D Kumararatne, R Doffinger, AJ Thrasher, S Nejentsev
Feb 13, 2017
Alleles Amino Acid Sequence Base Sequence Blood Cells Child Child Preschool Cytokines Disease Susceptibility Female FIBROBLASTS Gene Expression Regulation Humans Interferon-alpha Interferon-gamma Janus Kinase 1 Male Mutation Mycobacterium Infections Pedigree Phosphorylation Protein Domains STAT Transcription Factors Signal Transduction TYK2 Kinase Young Adult
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Cover Image for Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS) View Article
Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS)
G Bellingan, F Jacono, J Bannard-Smith, D Brealey, N Meyer, D Thickett, D Young, A Bentley, BJ McVerry, RG Wunderink, KC Doerschug, Charlotte Summers, M Rojas, A Ting, ED Jenkins
Jan 07, 2022
Acute respiratory distress syndrome (ARDS) Stem Cells Multipotent Adult Progenitor Cells (Mapc)
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