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Results: 6
Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia.
Andrew Conway Morris, Kallirroi Kefala, Thomas S Wilkinson, Olga Lucia Moncayo-Nieto, Kevin Dhaliwal, Lesley Farrell, Timothy S Walsh, Simon J Mackenzie, David G Swann, Peter JD Andrews, Niall Anderson, John RW Govan, Ian F Laurenson, Hamish Reid, Donald J Davidson, Christopher Haslett, Jean-Michel Sallenave, A John Simpson
Jul 02, 2020
BACKGROUND: Ventilator-associated pneumonia (VAP) is the most commonly fatal nosocomial infection. Clinical diagnosis of VAP remains notoriously inaccurate. The hypothesis was tested that significantly augmented inflammatory...
Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining.
Antonia Kefala Stavridi, Robert Appleby, Shikang Liang, Tom L Blundell, Amanda K Chaplin
Mar 11, 2021
Non-homologous end joining (NHEJ) is one of the two principal damage repair pathways for DNA double-strand breaks in cells. In this review, we give a brief overview of the system including a discussion of the effects of...
Stages, scaffolds and strings in the spatial organisation of non-homologous end joining
Shikang Liang, Amanda K Chaplin, Antonia Kefala Stavridi, Robert Appleby, Ales Hnizda, Tom L Blundell
Jan 20, 2021
Non-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the...
Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.
Thomas P Hellyer, Andrew Conway Morris, Daniel F McAuley, Timothy S Walsh, Niall H Anderson, Suveer Singh, Paul Dark, Alistair I Roy, Simon V Baudouin, Stephen E Wright, Gavin D Perkins, Kallirroi Kefala, Melinda Jeffels, Ronan McMullan, Cecilia M O'Kane, Craig Spencer, Shondipon Laha, Nicole Robin, Savita Gossain, Kate Gould, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Emma M Browne, James G MacFarlane, Sarah Wiscombe, John D Widdrington, Ian Dimmick, Ian F Laurenson, Frans Nauwelaers, A John Simpson
Jun 26, 2020
BACKGROUND: Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful...
Dimers of DNA-PK create a stage for DNA double-strand break repair.
Amanda K Chaplin, Steven W Hardwick, Shikang Liang, Antonia Kefala Stavridi, Ales Hnizda, Lee R Cooper, Taiana Maia De Oliveira, Dimitri Y Chirgadze, Tom L Blundell
Aug 25, 2020
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Amanda K Chaplin, Steven W Hardwick, Antonia Kefala Stavridi, Christopher J Buehl, Noah J Goff, Virginie Ropars, Shikang Liang, Taiana Maia De Oliveira, Dimitri Y Chirgadze, Katheryn Meek, Jean-Baptiste Charbonnier, Tom L Blundell
Jul 12, 2021
DNA Repair DNA-PK NHEJ cryo-EM long-range synaptic complexes Non-homologous end joining Apoptosis Cryoelectron Microscopy DNA Breaks Double-Stranded DNA Damage DNA End-Joining Repair DNA Ligase ATP DNA Repair DNA Repair Enzymes DNA-Activated Protein Kinase DNA-Binding Proteins Humans Ku Autoantigen Multiprotein Complexes Phosphorylation