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Results: 47
Probabilistic landscape of seizure semiology localizing values.
Ali Alim-Marvasti, Gloria Romagnoli, Karan Dahele, Hadi Modarres, Fernando Pérez-García, Rachel Sparks, Sébastien Ourselin, Matthew J Clarkson, Fahmida Chowdhury, Beate Diehl, John S Duncan
Jul 07, 2022
Semiology describes the evolution of symptoms and signs during epileptic seizures and contributes to the evaluation of individuals with focal drug-resistant epilepsy for curative resection. Semiology varies in complexity from...
A Supervised Learning-Based Framework for Predicting COVID-19 in Patients
The integration of ML and loT can provide insightful details for critical decision making, automated responses, etc. Predicting future trends and detecting anomalies are some of the areas where loT and ML are being used at a...
Grid & High Performance Computing Computer Science and Information Technology High Performance Computing
Published by: IGI Global Scientific Publishing
Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β-/-) murine hearts.
Shiraz Ahmad, Haseeb Valli, Karan R Chadda, James Cranley, Kamalan Jeevaratnam, Christopher L-H Huang
Sep 05, 2018
Action potential conduction Fibrosis MITOCHONDRIAL DYSFUNCTION peroxisome proliferator activated receptor-γ coactivator-1 (PGC-1) Ventricular arrhythmia Action Potentials aging Animals Arrhythmias Cardiac Fibrosis Mice Mice Knockout Mitochondria Heart Models Cardiovascular Myocardium Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
A rare case of paediatric astroblastoma with concomitant MN1-GTSE1 and EWSR1-PATZ1 gene fusions altering management.
Karan R Chadda, Katherine Holland, Daniel Scoffings, Andrew Dean, Jessica C Pickles, Sam Behjati, Thomas S Jacques, Jamie Trotman, Patrick Tarpey, Kieren Allinson, Matthew J Murray, Genomics England Research Consortium
Feb 04, 2021
Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed?
While the increased arrhythmic tendency during acute COVID-19 infection is recognised, the long-term cardiac electrophysiological complications are less well known. There are a high number of patients reporting ongoing symptoms...
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Charlotte E Edling, Ibrahim T Fazmin, Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L-H Huang, Kamalan Jeevaratnam
Jan 02, 2020
INTRODUCTION:Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP)...
The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3.
Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Ingrid den Uijl, Ali Bak Al-Hadithi, Samantha C Salvage, Andrew A Grace, Christopher L-H Huang, Kamalan Jeevaratnam
Sep 29, 2018
Long QT Syndrome 3 (LQTS3) arises from gain-of-function Nav1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent risk for major arrhythmic...
Cardiac electrophysiological adaptations in the equine athlete-Restitution analysis of electrocardiographic features.
Mengye Li, Karan R Chadda, Gareth DK Matthews, Celia M Marr, Christopher L-H Huang, Kamalan Jeevaratnam
Sep 10, 2018
Exercising horses uniquely accommodate 7-8-fold increases in heart rate (HR). The present experiments for the first time analysed the related adaptations in action potential (AP) restitution properties recorded by in vivo...
A rare case of paediatric astroblastoma with concomitant MN1 ‐ GTSE1 and EWSR1 ‐ PATZ1 gene fusions altering management
Karan R. Chadda, Katherine Holland, Daniel Scoffings, Andrew Dean, Jessica C. Pickles, Sam Behjati, Thomas S. Jacques, Jamie Trotman, Patrick Tarpey, Kieren Allinson, Matthew J. Murray, Genomics England Research Consortium
Sep 21, 2021
Published by: Neuropathology and Applied Neurobiology
Targeted transperineal biopsy of the prostate has limited additional benefit over background cores for larger MRI-identified tumors.
Tristan Barrett, Andrew J Patterson, Brendan C Koo, Karan Wadhwa, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
Jul 24, 2015
Image-guided biopsy Magnetic Resonance Imaging prostate cancer Transperineal ULTRASOUND Aged Follow-Up Studies Humans Image-Guided Biopsy Magnetic Resonance Imaging Interventional Male Middle Aged Neoplasm Grading Perineum Prostate Prostatic Neoplasms Reproducibility of Results Retrospective Studies Ultrasonography Interventional
Biosensor for Multimodal Characterization of an Essential ABC Transporter for Next-Generation Antibiotic Research.
Karan Bali, Charlotte Guffick, Reece McCoy, Zixuan Lu, Clemens F Kaminski, Ioanna Mela, Róisín M Owens, Hendrik W van Veen
Apr 02, 2023
MsbA PEDOT:PSS Atomic force microscopy Biosensor electrochemical impedance spectroscopy Electrophysiology structured illumination microscopy Supported lipid bilayer ATP-Binding Cassette Transporters Bacterial Proteins Lipid Bilayers Anti-Bacterial Agents Escherichia coli Adenosine Triphosphate Biosensing Techniques
Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.
Julia Steinberg, Lorraine Southam, Andreas Fontalis, Matthew J Clark, Raveen L Jayasuriya, Diane Swift, Karan M Shah, Roger A Brooks, Andrew W McCaskie, Jeremy Mark Wilkinson, Eleftheria Zeggini
May 03, 2021
OBJECTIVES: To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular classification algorithm. METHODS: We...
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Charlotte E Edling, Ibrahim T Fazmin, Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L-H Huang, Kamalan Jeevaratnam
Jan 08, 2020
INTRODUCTION: Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP)...
Ageing in Pgc-1β-/- mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology.
Charlotte E Edling, Ibrahim T Fazmin, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Andrew A Grace, Christopher L-H Huang, Kamalan Jeevaratnam
Jun 20, 2019
Mice deficient in mitochondrial promoter peroxisome proliferator activated receptor-γ co-activator-1β (Pgc-1β-/- ) is a valuable model for metabolic diseases and has been found to present with several pathologies including...
Peroxisome proliferator activated receptor-γ coactivator-1 Cardiac arrhythmia gene expression and regulation Ion Channels metabolic syndromes aging Animals Arrhythmias Cardiac Gene Deletion Gene Expression Regulation Heart Ventricles Membrane Potentials Mice Mice Inbred C57BL Mice Knockout Mitochondria Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Transcriptome Ventricular Function
Investigating the ability of multiparametric MRI to exclude significant prostate cancer prior to transperineal biopsy.
Eva M Serrao, Tristan Barrett, Karan Wadhwa, Deepak Parashar, Julia Frey, Brendan C Koo, Anne Y Warren, Andrew Doble, Christof Kastner, Ferdia A Gallagher
Sep 12, 2016
Biosensor for Multimodal Characterization of an Essential ABC Transporter for Next-Generation Antibiotic Research.
Karan Bali, Charlotte Guffick, Reece McCoy, Zixuan Lu, Clemens F Kaminski, Ioanna Mela, Róisín M Owens, Hendrik W van Veen
Mar 16, 2023
MsbA PEDOT:PSS Atomic force microscopy Biosensor electrochemical impedance spectroscopy Electrophysiology structured illumination microscopy Supported lipid bilayer ATP-Binding Cassette Transporters Bacterial Proteins Lipid Bilayers Anti-Bacterial Agents Escherichia coli Adenosine Triphosphate Biosensing Techniques
Identification of potential therapeutic targets in prostate cancer through a cross-species approach.
Sarah Jurmeister, Antonio Ramos-Montoya, Chiranjeevi Sandi, Nelma Pértega-Gomes, Karan Wadhwa, Alastair D Lamb, Mark J Dunning, Jan Attig, Jason S Carroll, Lee GD Fryer, Sérgio L Felisbino, David E Neal
Mar 28, 2018
Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development...
MELK cross‐species analysis Mouse models new cancer targets prostate cancer Animals Carcinogenesis Cell Line Tumor Cell Proliferation Cell Survival Disease Progression Down-Regulation Gene Expression Profiling Gene Expression Regulation Neoplastic Genome Humans Male Mice Molecular Targeted Therapy Naphthyridines Neoplasm Invasiveness Phenotype Phosphorylation Prostatic Neoplasms Protein Serine-Threonine Kinases Species Specificity Spindle Apparatus Stathmin Transcriptome
A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations.
Gabriel Sturm, Anna S Monzel, Kalpita R Karan, Jeremy Michelson, Sarah A Ware, Andres Cardenas, Jue Lin, Céline Bris, Balaji Santhanam, Michael P Murphy, Morgan E Levine, Steve Horvath, Daniel W Belsky, Shuang Wang, Vincent Procaccio, Brett A Kaufman, Michio Hirano, Martin Picard
Jan 04, 2023
Aging is a process of progressive change. To develop biological models of aging, longitudinal datasets with high temporal resolution are needed. Here we report a multi-omics longitudinal dataset for cultured primary human...
Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis
Epidemiology, Outcomes and Resource Utilisation in Patients with Carbapenem Non-susceptible Gram-Negative Bacteria in the UK
Simon D Goldenberg, Andrew R Dodgson, Gavin Barlow, Benjamin J Parcell, Lim Jones, Mahableshwar Albur, A Peter R Wilson, David A Enoch, Aleks Marek, Christianne Micallef, Davide Manissero, Christopher Longshaw, Sara Lopes, Karan Gill
Jul 25, 2022
A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations.
Gabriel Sturm, Anna S Monzel, Kalpita R Karan, Jeremy Michelson, Sarah A Ware, Andres Cardenas, Jue Lin, Céline Bris, Balaji Santhanam, Michael P Murphy, Morgan E Levine, Steve Horvath, Daniel W Belsky, Shuang Wang, Vincent Procaccio, Brett A Kaufman, Michio Hirano, Martin Picard
Dec 08, 2022
Aging is a process of progressive change. To develop biological models of aging, longitudinal datasets with high temporal resolution are needed. Here we report a multi-omics longitudinal dataset for cultured primary human...
Tailoring the Surface Chemistry of PEDOT
Konstantinos Kallitsis, Anna‐Maria Pappa, Zixuan Lu, Alberto Alvarez‐Fernandez, Ioanna Charalambous, Sina Schack, Walther C Traberg, Quentin Thiburce, Karan Bali, Graham Christie, Stefan Guldin, Susan Daniel, Alberto Salleo, Róisín M Owens
Apr 14, 2023
This communication reports on a versatile and substrate‐agnostic method to tune the surface chemistry of conducting polymers with the aim of bridging the chemical mismatch between bioelectronic devices and biological systems. As...
A molecular quantitative trait locus map for osteoarthritis
Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini
Apr 13, 2021
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