Introduction: Insulin resistance, dyslipidemia and hypertension may co-exist in 15-25 % of individuals in industrialized countries. Vasodilator amodipine, ramipril and enalapril being commonly used drugs, were selected to see...
BACKGROUND: Activation of beta-1 adrenoreceptor (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure. Genetic variation in β1-AR could therefore alter the physiological and clinical...
BACKGROUND: Epidemiologic evidence suggests that low-fat dairy consumption may lower risk of hypertension. Dairy products may be distinctly linked to health, because of differences in nutritional composition, but little is known...
Introduction: Insulin resistance, dyslipidemia and hypertension may co-exist in 15-25 % of individuals in industrialized countries. Vasodilator amodipine, ramipril and enalapril being commonly used drugs, were selected to see...
BACKGROUND AND PURPOSE: The link between brain iron deficiency and RLS is now well established. In a related observation, several conditions that can deplete iron stores have been linked to increased probability of RLS. Blood...
Central systolic blood pressure (cSBP, the peak of the central waveform) is usually regarded as the determinant of peripheral systolic blood pressure with amplification of peripheral systolic blood pressure (pSBP) measured with...
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood...
This paper explores the sexual politics present in Shakespeare's The Taming of the Shrew, examining the gender roles that influence the relationship between Katherine and Petruccio. By analyzing Petruccio's attempts at taming...
In the countries or areas where the supply-demand ratio of blood is not maintained, the medication process is being deteriorated, and this may be as fatal as death of the patients. It is being observed in different areas in...
Lipid peroxidation is a normal phenomenon occurring continuously at low level in all human beings, which is effectively counteracted by antioxidant mechanisms. Oxidative stress is implicated in development of utero-placental...
INTRODUCTION: Self-monitoring of blood pressure is effective in reducing blood pressure in hypertension. However previous meta-analyses have shown a considerable amount of heterogeneity between studies, only part of which can be...
Lipid peroxidation is a normal phenomenon occurring continuously at low level in all human beings, which is effectively counteracted by antioxidant mechanisms. Oxidative stress is implicated in development of utero-placental...
Vital organs are exposed to the central rather than the brachial blood pressure. To date, central blood pressure can be assessed noninvasively through the use of several devices. In this review, we critically discuss the...
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as...
Haematopoietic stem cells give rise to all lineages of blood cell, and their production $\textit{in vitro}$ has been a long-sought goal of stem-cell biology. Two groups now achieve this feat through different means.
BACKGROUND: Screening participants with abnormal faecal occult blood test results who do not attend further testing are at high risk of colorectal cancer, yet little is known about their reasons for non-attendance. METHODS: We...
Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental thermodynamic limitations of conventional magnetic resonance, and is translating to human studies with several early-phase clinical trials in...
India faces numerous challenges to the meet ever-increasing demand of human blood so as to improve the health indicators across its rural and urban population. The gap between demand and supply can be fulfilled by increasing...
BACKGROUND: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and...
Pregnancy is not a disease or illness, but requires clinical surveillance as life-threatening complications can develop. Preeclampsia, one such potentially serious complication, puts both mother and baby at risk. Self-monitoring...
Brain protein biomarker clearance to blood in traumatic brain injury (TBI) is not fully understood. The aim of this study was to analyze the effect that a disrupted blood-brain barrier (BBB) had on biomarker clearance. Seventeen...
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic...
Oral glucose tolerance and insulin sensitivity are common measures, but are determined using various blood sampling methods, employed under many different experimental conditions. This study established whether measures of oral...
BACKGROUND: Self-monitoring of blood pressure (BP) appears to reduce BP in hypertension but important questions remain regarding effective implementation and which groups may benefit most. This individual patient data (IPD)...