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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
Corrections to: Use of the BOADICEA Web Application in clinical practice
Anne Brédart, Jean-Luc Kop, Antonis C Antoniou, Alex P Cunningham, Antoine de Pauw, Marc Tischkowitz, Hans Ehrencrona, Sylvie Dolbeault, Léonore Robieux, Kerstin Rhiem, Douglas F Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Jan 23, 2018
The article "Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries" written by Anne Brédart · Jean‑Luc Kop · Antonis C. Antoniou · Alex P. Cunningham · Antoine De Pauw ·Marc...
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
Mind the context gap
In this review paper, we critically examine the evidence base relating to engagement within the public sector given a wide range of public services have faced acute human resource challenges over recent years. Our review of 188...
Developing drought impact functions for drought risk management
Drought management frameworks are dependent on methods for monitoring and prediction, but quantifying the hazard alone is arguably not sufficient; the negative consequences that may arise from a lack of precipitation must also...
Diurnal oscillations in gut bacterial load and composition eclipse seasonal and lifetime dynamics in wild meerkats.
Circadian rhythms in gut microbiota composition are crucial for metabolic function, yet the extent to which they govern microbial dynamics compared to seasonal and lifetime processes remains unknown. Here, we investigate gut...
Mind the context gap
In this review paper, we critically examine the evidence base relating to engagement within the public sector given a wide range of public services have faced acute human resource challenges over recent years. Our review of 188...
Small-Molecule Activation of YAP for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Modelling Charcot-Marie-Tooth disease in a dish reveals common cell type-specific alterations.
This scientific commentary refers to ‘Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction’, by Van Lent et al. (doi:10.1093/brain/awab226).
Small Molecule Activation of Yap for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Developing drought impact functions for drought risk management
Drought management frameworks are dependent on methods for monitoring and prediction, but quantifying the hazard alone is arguably not sufficient; the negative consequences that may arise from a lack of precipitation must also...
Gedanken über die Religion: Der “stille” Krieg zwischen Schelling und Schleiermacher (1799–1807), by Ryan Scheerlinck, Stuttgart-Bad Cannstatt
Vicki Müller-Lüneschloß
Apr 05, 2022
The title of Scheerlinck’s study on the relationship between two of the most important thinkers of Romanticism, the philosopher F.W.J. Schelling and the theologian F.D.E. Schleiermacher, undoubtedly alludes to the latter’s main...
Published by: Memorial University Libraries
Comment on Late-Onset ADHD Reconsidered With Comprehensive Repeated Assessments Between Ages 10 and 25.
Attention Deficit Hyperactivity Disorder Diagnosis And Classification EPIDEMIOLOGY Adolescent Adult Age Factors Attention Deficit Disorder with Hyperactivity Child Diagnostic and Statistical Manual of Mental Disorders Humans Young Adult
Published by: Am J Psychiatry
Multigrid preconditioners for the hybridized Discontinuous Galerkin discretisation of the shallow water equations
Numerical climate- and weather-prediction models require the fast solution of the equations of fluid dynamics. Discontinuous Galerkin (DG) discretisations have several advantageous properties. They can be used for arbitrary...
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