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Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency.
Emma Bell, Edward W Curry, Wout Megchelenbrink, Luc Jouneau, Vincent Brochard, Rute A Tomaz, King Hang T Mau, Yaser Atlasi, Roshni A de Souza, Hendrik Marks, Hendrik G Stunnenberg, Alice Jouneau, Véronique Azuara
May 04, 2020
Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood....
Humanitarianism, race, and denial
Y Pringle
Aug 08, 2017
This article explores the humanitarian principles of universality, impartiality, and neutrality, and the moral boundaries of humanitarian action in the past. It does so through a case study of the International Committee of the...
IPR Policy Brief - Advergames
llowing the Bailey Review of the Commercialisation and Sexualisation of Childhood (2011), David Cameron asked the Advertising Standards Authority (ASA) to consider whether more should be done to spell out the commercial intent...
Published by: University of Bath
IPR Policy Brief - Advergames
llowing the Bailey Review of the Commercialisation and Sexualisation of Childhood (2011), David Cameron asked the Advertising Standards Authority (ASA) to consider whether more should be done to spell out the commercial intent...
Published by: University of Bath
Upperclassmen Selected as Homecoming King and Queen
Winthrop University
Jan 01, 0001
Junior Ron Nelson and senior Sharetta Wynn were voted Homecoming King and Queen for Winthrop's Homecoming Fall 2009. They accepted their crowns Saturday, Nov. 14, during halftime of the men's basketball game against Limestone...
Published by: Winthrop University
Homecoming King and Queen Crowned Nov. 13
Winthrop University
Jan 01, 0001
Senior Ray Singleton of North Charleston, S.C., and senior Beyanca Vinson, of Fort Mill, S.C., were voted Homecoming King and Queen by their fellow students for Winthrop's Homecoming Fall 2010 held Nov. 9-13. The two accepted...
Published by: Winthrop University
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Press Release: The King Legacy - Thoughts From the Ursinus College Community
College Communications
Jan 01, 0001
News article which recounts how Reverend Martin Luther King Jr. came to impact the life of Reverend Charles Rice.
Reverend Charles Rice Martin Luther King Jr. Ursinus College Brooklyn Let the Trumpet Sound Shirley Chisholm Other America African American Studies Civil Rights and Discrimination Higher Education Liberal Studies United States History
Published by: Ursinus College
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Seniors Crowned Homecoming King and Queen on Nov. 9
Winthrop University
Jan 01, 0001
Seniors DeShawn Clement of Greenville, S.C., and Daisy Burroughs of Columbia, S.C., were voted Homecoming King and Queen by their fellow students for Winthrop's 2013 Homecoming held Nov. 4-10. They accepted their crowns during...
Published by: Winthrop University
Homecoming King and Queen Crowned Nov. 12 at Basketball Game
Winthrop University
Jan 01, 0001
Seniors TyQuan Butler of Sumter, South Carolina, and Janay Reece of Charlotte, North Carolina, were voted Homecoming King and Queen by their fellow students for Winthrop's 2016 Homecoming held Nov. 7-12. They accepted their...
Published by: Winthrop University
Greer Students Crowned as Homecoming King and Queen
Winthrop University
Jan 01, 0001
Fellow students voted online for junior Willie Meier and senior Tori McLean as Homecoming King and Queen for Winthrop's Homecoming Fall 2011. Meier and McLean accepted their crowns Saturday, Nov. 12, during halftime of the men's...
Published by: Winthrop University
A simple spatial extension to the extended connectivity interaction features for binding affinity prediction
The representation of the protein-ligand complexes used in building machine learning models play an important role in the accuracy of binding affinity prediction. The Extended Connectivity Interaction Features (ECIF) is one such...
A simple spatial extension to the extended connectivity interaction features for binding affinity prediction.
The representation of the protein-ligand complexes used in building machine learning models play an important role in the accuracy of binding affinity prediction. The Extended Connectivity Interaction Features (ECIF) is one such...
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A Teichmann, Fan Bai, Yang Wang
Apr 03, 2022
Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Winthrop Observes Social Justice Week Along with King Day from Jan. 19-23
Winthrop University
Jan 01, 0001
Social Justice Week held to uplift Rock Hill community. Activities include King Day for Kids, Hunger Banquet and a documentary on AIDS.
Published by: Winthrop University
Martin Luther King Jr. Activities Planned for Jan. 16
Winthrop University
Jan 01, 0001
Winthrop will celebrate Martin Luther King Jr. Day on Jan. 16 with a number of activities including a prayer breakfast, a candlelight vigil, a unity rally and more.
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
King Day for Kids Postponed; Winthrop Students Encouraged to Participate in Community Service Project
Winthrop University
Jan 01, 0001
Area school children were going to have Martin Luther King Jr. Day off as a holiday but some school districts will use that day now as a snow makeup day. University students are encouraged to participate in a service project...
Published by: Winthrop University
Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin.
Emily FA van 't Wout, Jennifer A Dickens, Annemarie van Schadewijk, Imran Haq, Hang Fai Kwok, Adriana Ordóñez, Gillian Murphy, Jan Stolk, David A Lomas, Pieter S Hiemstra, Stefan J Marciniak
May 18, 2018
Overexpression of Z α1-antitrypsin is known to induce polymer formation, prime the cells for endoplasmic reticulum stress and initiate nuclear factor kappa B (NF-κB) signalling. However, whether endogenous expression in primary...
ADAM Proteins ADAM17 Protein Cell Line Tumor Cytokines Endoplasmic reticulum stress Epithelial Cells ErbB Receptors Humans Inflammation Mediators Lung MAP Kinase Signaling System Mutation Missense NF-kappa B Primary Cell Culture Protein Multimerization Protein Processing Post-Translational Signal Transduction alpha 1-Antitrypsin
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
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