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Results: 163
Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes.
Lindsay McDonald, Mathieu Cayla, Alasdair Ivens, Binny M Mony, Paula MacGregor, Eleanor Silvester, Kirsty McWilliam, Keith R Matthews
Feb 28, 2019
Trypanosoma brucei, the agents of African trypanosomiasis, undergo density-dependent differentiation in the mammalian bloodstream to prepare for transmission by tsetse flies. This involves the generation of cell-cycle arrested...
Self-criticism as a mediator in the relationship between unhealthy perfectionism and distress
Unhealthy or negative perfectionism has been identified as both a risk and maintaining factor for a range of psychological difficulties. A cross-sectional online study with a predominantly student population (n = 381)...
Older adult hoarders’ experiences of being helped by volunteers and volunteers' experiences of helping
Background:
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
What are the barriers to the SHAI being completed within a CFS/ME service?
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition, characterised by unexplained and excessive fatigue, muscle pain and sleep disturbances. Health anxiety is common in ME/CFS and accurate...
Self-criticism as a mediator in the relationship between unhealthy perfectionism and distress
Unhealthy or negative perfectionism has been identified as both a risk and maintaining factor for a range of psychological difficulties. A cross-sectional online study with a predominantly student population (n = 381)...
Older adult hoarders’ experiences of being helped by volunteers and volunteers' experiences of helping
Background:
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
Best Practices for Event Amplification
This report gives an overview of the current and emerging best practice in the field of amplified and hybrid events within the UK higher and further education sector. It explores the role of amplified and hybrid events in...
Published by: UKOLN
Session-by-session outcome monitoring in CAMHS
The CYP-IAPT programme emphasises the meaningful contribution session-by-session routine outcome monitoring (ROM) can make to clinical practice and its importance in highlighting services’ effectiveness. Two studies on issues...
FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).
Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennett
Oct 03, 2018
OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a...
Muscle Smooth Vascular Cells Cultured Extracellular Matrix Myocytes Smooth Muscle Animals Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Humans Rats Wistar Carotid Artery Injuries Disease Models Animal Fibrosis Necrosis Signal Transduction Apoptosis Mutation Male Atherosclerosis Matrix Metalloproteinase 13 Transcriptional Activation Vascular Remodeling Forkhead Box Protein O3 Mice Knockout ApoE
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells.
Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett
Jul 02, 2020
Apoptosis cytokine Proliferation Vascular smooth muscle Animals Apoptosis blood vessels Cell Proliferation Cells Cultured Cytokines Gene Expression Regulation Developmental Granulocyte-Macrophage Colony-Stimulating Factor Heparin-binding EGF-like Growth Factor Humans Interleukin-6 MAP Kinase Kinase 4 Mice Muscle Smooth Vascular Myocytes Smooth Muscle Oncogene Protein v-akt Signal Transduction Staurosporine fas Receptor p38 Mitogen-Activated Protein Kinases
The contribution of cognitive behavioural factors to social anxiety in Parkinson's disease
BACKGROUND: Social anxiety is prevalent in idiopathic Parkinson's disease but why this is, is not yet well understood. Social cognitions, safety-seeking behaviours and internally focused attention are all known to predict...
Two new methods to fit models for network meta-analysis with random inconsistency effects.
BACKGROUND: Meta-analysis is a valuable tool for combining evidence from multiple studies. Network meta-analysis is becoming more widely used as a means to compare multiple treatments in the same analysis. However, a network...
The contribution of cognitive behavioural factors to social anxiety in Parkinson's disease
BACKGROUND: Social anxiety is prevalent in idiopathic Parkinson's disease but why this is, is not yet well understood. Social cognitions, safety-seeking behaviours and internally focused attention are all known to predict...
What are the barriers to the SHAI being completed within a CFS/ME service?
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition, characterised by unexplained and excessive fatigue, muscle pain and sleep disturbances. Health anxiety is common in ME/CFS and accurate...
Hearing loss in inner ear and systemic autoimmune disease
Abstract: Objectives: To assess outcomes following cochlear implantation (CI) in patients with hearing loss secondary to primary or secondary autoimmune inner ear disease (AIED). Methods: A systematic review and narrative...
Computer-tailored smoking cessation advice matched to reading ability
OBJECTIVE: To explore perceptions of computer-tailored advice reports for smoking cessation matched to the recipient's reading level. METHODS: Current cigarette smokers in the UK aged 18-65 who completed a Smoking Behavior...
Best Practices for Event Amplification
This report gives an overview of the current and emerging best practice in the field of amplified and hybrid events within the UK higher and further education sector. It explores the role of amplified and hybrid events in...
Published by: UKOLN
No apparent benefits of allonursing for recipient offspring and mothers in the cooperatively breeding meerkat.
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