Search
Results: 186
Rationalisation of the UK Nutrient Databank for Incorporation in a Web-Based Dietary Recall for Implementation in the UK National Diet and Nutrition Survey Rolling Programme.
Birdem Amoutzopoulos, Toni Steer, Caireen Roberts, David Collins, Kirsty Trigg, Rachel Barratt, Suzanna Abraham, Darren James Cole, Angela Mulligan, Jackie Foreman, Anila Farooq, Polly Page
Nov 15, 2022
Rationalisation of the UK Nutrient Databank for Incorporation in a Web-Based Dietary Recall for Implementation in the UK National Diet and Nutrition Survey Rolling Programme
Birdem Amoutzopoulos, Toni Steer, Caireen Roberts, David Collins, Kirsty Trigg, Rachel Barratt, Suzanna Abraham, Darren James Cole, Angela Mulligan, Jackie Foreman, Anila Farooq, Polly Page
Nov 04, 2022
Diagnostic accuracy of circulating-free DNA for the determination of MYCN amplification status in advanced-stage neuroblastoma
BACKGROUND: MYCN amplification (MNA) is the strongest indicator of poor prognosis in neuroblastoma (NB). This meta-analysis aims to determine the diagnostic accuracy of MNA analysis in circulating-free DNA (cfDNA) from...
ALK in Neuroblastoma
Neuroblastoma (NB) is the most common and deadly solid tumour in children. Despite the development of new treatment options for high-risk NB, over half of patients relapse and five-year survival remains at 40-50%. Therefore...
Factors that influence quality and yield of circulating-free DNA
BACKGROUND: Circulating-free DNA (cfDNA) is under investigation as a liquid biopsy of cancer for early detection, monitoring disease progression and therapeutic response. This systematic review of the primary cfDNA literature...
Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA.
Callum P Rakhit, Ricky M Trigg, John Le Quesne, Michael Kelly, Jacqueline A Shaw, Catrin Pritchard, L Miguel Martins
Feb 07, 2019
Circulating free DNA Early detection KRASG12D Lung adenocarcinoma mouse model cfDNA Alleles Animals Cell-Free Nucleic Acids Disease Models Animal Early Detection of Cancer Female Integrases Lung Neoplasms Male Mice Inbred C57BL Mutation Precancerous Conditions Proto-Oncogene Proteins p21(ras) Recombination Genetic Reproducibility of Results Tumor Burden X-Ray Microtomography
Diagnostic accuracy of circulating-free DNA for the determination of MYCN amplification status in advanced-stage neuroblastoma
Abstract: Background: MYCN amplification (MNA) is the strongest indicator of poor prognosis in neuroblastoma (NB). This meta-analysis aims to determine the diagnostic accuracy of MNA analysis in circulating-free DNA (cfDNA) from...
Opportunities and challenges of circulating biomarkers in neuroblastoma.
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging...
Contextual Flexibility in Pseudomonas aeruginosa Central Carbon Metabolism during Growth in Single Carbon Sources.
Stephen K Dolan, Michael Kohlstedt, Stephen Trigg, Pedro Vallejo Ramirez, Clemens F Kaminski, Christoph Wittmann, Martin Welch
Apr 18, 2020
Pseudomonas aeruginosa is an opportunistic human pathogen, particularly noted for causing infections in the lungs of people with cystic fibrosis (CF). Previous studies have shown that the gene expression profile of P. aeruginosa...
Pseudomonas aeruginosa denitrification Proteomics carbon metabolism carbon flux acetate metabolism glycerol metabolism
Published by: mBio
Self-criticism as a mediator in the relationship between unhealthy perfectionism and distress
Unhealthy or negative perfectionism has been identified as both a risk and maintaining factor for a range of psychological difficulties. A cross-sectional online study with a predominantly student population (n = 381)...
Older adult hoarders’ experiences of being helped by volunteers and volunteers' experiences of helping
Background:
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M. Trigg, John A. Williams, Joao Pereira, Megan L. Cavanagh, Suzanne D. Turner, Georgios V. Gkoutos, Loukia Tsaprouni
Aug 11, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
What are the barriers to the SHAI being completed within a CFS/ME service?
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition, characterised by unexplained and excessive fatigue, muscle pain and sleep disturbances. Health anxiety is common in ME/CFS and accurate...
Self-criticism as a mediator in the relationship between unhealthy perfectionism and distress
Unhealthy or negative perfectionism has been identified as both a risk and maintaining factor for a range of psychological difficulties. A cross-sectional online study with a predominantly student population (n = 381)...
Older adult hoarders’ experiences of being helped by volunteers and volunteers' experiences of helping
Background:
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
There is limited research into the experiences of receiving and providing help in the context of hoarding disorder.
Aims:
The present study aimed to explore the experiences of older people with...
Best Practices for Event Amplification
This report gives an overview of the current and emerging best practice in the field of amplified and hybrid events within the UK higher and further education sector. It explores the role of amplified and hybrid events in...
Published by: UKOLN
The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection.
Ben J Trigg, Katharina B Lauer, Paula Fernandes Dos Santos, Heather Coleman, Gabriel Balmus, Daniel S Mansur, Brian J Ferguson
Jun 08, 2018
Herpes simplex virus 1 (HSV-1) has extensive interactions with the host DNA damage response (DDR) machinery that can be either detrimental or beneficial to the virus. Proteins in the homologous recombination pathway are known to...
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers.
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M Trigg, John A Williams, Joao Pereira, Megan L Cavanagh, Suzanne D Turner, Georgios V Gkoutos, Loukia Tsaprouni
Aug 06, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
Contextual Flexibility in Pseudomonas aeruginosa Central Carbon Metabolism during Growth in Single Carbon Sources.
Stephen K Dolan, Michael Kohlstedt, Stephen Trigg, Pedro Vallejo Ramirez, Clemens F Kaminski, Christoph Wittmann, Martin Welch
Feb 12, 2020
Session-by-session outcome monitoring in CAMHS
The CYP-IAPT programme emphasises the meaningful contribution session-by-session routine outcome monitoring (ROM) can make to clinical practice and its importance in highlighting services’ effectiveness. Two studies on issues...
FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).
Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennett
Oct 03, 2018
OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a...
Muscle Smooth Vascular Cells Cultured Extracellular Matrix Myocytes Smooth Muscle Animals Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Humans Rats Wistar Carotid Artery Injuries Disease Models Animal Fibrosis Necrosis Signal Transduction Apoptosis Mutation Male Atherosclerosis Matrix Metalloproteinase 13 Transcriptional Activation Vascular Remodeling Forkhead Box Protein O3 Mice Knockout ApoE
|
|< |
< |
1 |