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Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, Alexia Ville, Ida Cerqua, Guillaume Viault, Dimitri Bréard, Simona Pace, Veronika Temml, Elena Brunner, Paul M Jordan, Marta C Marques, Konstantin Loeser, André Gollowitzer, Stephan Permann, Jana Gerstmeier, Stefan Lorkowski, Hermann Stuppner, Ulrike Garscha, Tiago Rodrigues, Gonçalo J L Bernardes, Daniela Schuster, Denis Séraphin, Pascal Richomme, Antonietta Rossi, Alexander S Mosig, Fiorentina Roviezzo, Oliver Werz, Jean-Jacques Helesbeux, Andreas Koeberle
Aug 26, 2021
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies...
Published by: Journal of medicinal chemistry
STRING FEVER
The Rockefeller University
Jan 01, 0001
String Fever: a new play by Jacquelyn Reingold
Followed by Q&A led by professor and physicist Konstantin A. Goulianos, Ph.D.
Published by: The Rockefeller University
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, Alexia Ville, Ida Cerqua, Guillaume Viault, Dimitri Bréard, Simona Pace, Veronika Temml, Elena Brunner, Paul M Jordan, Marta C Marques, Konstantin Loeser, André Gollowitzer, Stephan Permann, Jana Gerstmeier, Stefan Lorkowski, Hermann Stuppner, Ulrike Garscha, Tiago Rodrigues, Gonçalo JL Bernardes, Daniela Schuster, Denis Séraphin, Pascal Richomme, Antonietta Rossi, Alexander S Mosig, Fiorentina Roviezzo, Oliver Werz, Jean-Jacques Helesbeux, Andreas Koeberle
Jul 28, 2021
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies...
Rather doomed than uncertain
We analyze the relation between individuals' risk aversion and their willingness to expose themselves to infection when faced with an asymptomatic infectious disease. We show that in a high prevalence environment, increasing...
Predicting Pathways between Distant Configurations for Biomolecules.
Many of the most interesting rearrangements associated with function and dysfunction of biomolecules involve complex, highly nonlinear pathways. Predicting these convoluted changes in structure is an important research...
Mutational Basin-Hopping
The study of energy landscapes has led to a good understanding of how and why proteins and nucleic acids adopt their native structure. Through evolution, sequences have adapted until they exhibit a strongly funneled energy...
Energy Landscapes for the Aggregation of Aβ17-42.
The aggregation of the Aβ peptide (Aβ1-42) to form fibrils is a key feature of Alzheimer's disease. The mechanism is thought to be a nucleation stage followed by an elongation process. The elongation stage involves the...
Evolved Minimal Frustration in Multifunctional Biomolecules.
Protein folding is often viewed in terms of a funneled potential or free energy landscape. A variety of experiments now indicate the existence of multifunnel landscapes, associated with multifunctional biomolecules. Here, we...
Implementation of Text Mining in Socio-Economic Research
This work aims to analyze insights from social networks for identification of population satisfaction with pay level in Russia using the text mining approach. For this, a sentiment analysis framework was developed, which...
Published by: IGI Global Scientific Publishing
Fast Track Physics: [Dr. Konstantin Goulianos]
M. S. Kaplan
Jan 01, 0001
Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual...
Goulianos Konstantin Rockefeller University Scientists PARTICLE PHYSICS drift chamber particle collisions small angle physics Fermi National Accelerator Laboratory Cool Rodney CDF (Collider Detector at Fermilab) Tevatron Life Sciences
Published by: The Rockefeller University
Experimentally revealed stochastic preferences for multicomponent choice options.
Alexandre Pastor-Bernier, Konstantin Volkmann, Arkadiusz Stasiak, Fabian Grabenhorst, Wolfram Schultz
Jul 27, 2020
Realistic, everyday rewards contain multiple components. An apple has taste and size. However, we choose in single dimensions, simply preferring some apples to others. How can such single-dimensional preference relationships...
Energy Landscapes of Deoxyxylo- and Xylo-Nucleic Acid Octamers.
Artificial analogues of the natural nucleic acids have attracted interest as a diverse class of information storage molecules capable of self-replication. In this study, we use the computational potential energy landscape...
Structural transitions in the RNA 7SK 5' hairpin and their effect on HEXIM binding.
Konstantin Röder, Guillaume Stirnemann, Anne-Catherine Dock-Bregeon, David J Wales, Samuela Pasquali
Oct 31, 2019
7SK RNA, as part of the 7SK ribonucleoprotein complex, is crucial to the regulation of transcription by RNA-polymerase II, via its interaction with the positive transcription elongation factor P-TEFb. The interaction is induced...
Binding Sites Humans Molecular Dynamics Simulation Nucleic Acid Conformation Nucleotide Motifs Peptides Positive Transcriptional Elongation Factor B Protein Binding RNA Polymerase II RNA Small Cytoplasmic RNA-Binding Proteins Ribonucleoproteins Thermodynamics Transcription Factors Transcription Genetic
Single-Dimensional Human Brain Signals for Two-Dimensional Economic Choice Options.
Leo Chi U Seak, Konstantin Volkmann, Alexandre Pastor-Bernier, Fabian Grabenhorst, Wolfram Schultz
Nov 24, 2020
Speech Intelligibility and Spatial Release From Masking Improvements Using Spatial Noise Reduction Algorithms in Bimodal Cochlear Implant Users.
Ayham Zedan, Tim Jürgens, Ben Williges, Birger Kollmeier, Konstantin Wiebe, Julio Galindo, Thomas Wesarg
May 10, 2021
This study investigated the speech intelligibility benefit of using two different spatial noise reduction algorithms in cochlear implant (CI) users who use a hearing aid (HA) on the contralateral side (bimodal CI users). The...
Archaerhodopsin Selectively and Reversibly Silences Synaptic Transmission through Altered pH.
Mohamady El-Gaby, Yu Zhang, Konstantin Wolf, Christof J Schwiening, Ole Paulsen, Olivia A Shipton
Sep 15, 2016
archaerhodopsin asymmetry Behavior Hippocampus Long-term memory optogenetics pH reversible Synapses synaptic silencing Adenoviridae Animals Archaeal Proteins Bacterial Proteins CA1 Region Hippocampal CA3 Region Hippocampal Gene Expression Genetic Vectors Hydrogen-Ion Concentration Injections Intraventricular Luminescent Proteins Male Memory Long-Term Mice Mice Inbred C57BL Neuronal Plasticity Optical Imaging optogenetics Presynaptic Terminals Recombinant Fusion Proteins Stereotaxic Techniques Synaptic Transmission
Comparison of Reaction Time Between eSports Players of Different Genres and Sportsmen
Peter Bickmann, Konstantin Wechsler, Kevin Rudolf, Chuck Tholl, Ingo Froböse, Christopher Grieben
Jan 01, 2021
Quick reactions are considered important in both, traditional and electronic sports and research findings suggest that reaction time can be optimized by both sports activity and playing action video games. In this study...
Published by: IGI Global Scientific Publishing
Correlation between crystal purity and the charge density wave in 1T-VSe2
Charles Sayers, Liam Farrar, Simon Bending, Mattia Cattelan, Alfred Jones, Neil Fox, Gabriele Kociok-Kohn, Konstantin Koshmak, Jude Laverock, Luca Pasquali, Enrico Da Como
Feb 29, 2020
We examine the charge density wave (CDW) properties of 1T-VSe2 crystals grown by chemical vapor transport (CVT) under varying conditions. Specifically, we find that upon lowering the growth temperature (Tg<630°C), there is...
Nicola De Franceschi, Antti Arjonen, Nadia Elkhatib, Konstantin Denessiouk, Antoni G Wrobel, Thomas A Wilson, Jeroen Pouwels, Guillaume Montagnac, David J Owen, Johanna Ivaska
Jan 08, 2016
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