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Adapting the SHEL model in investigating industrial maintenance
Purpose – The purpose of this paper is to identify and categorise problems in knowledge management of industrial maintenance, and support successful maintenance through adapting the SHEL model. The SHEL model has been used...
Entrepreneurial Ecosystem Research
The entrepreneurial ecosystem stream of research is relatively new, yet it has started to attract the attention of scholars across a range of disciplines including international business and international entrepreneurship....
Published by: IGI Global Scientific Publishing
1 Clement, Jews and Judaism
JNB Carleton Paget
Mar 08, 2017
Der Aufsatz untersucht erneut die Bewertung des 1. Clemensbriefes in der Forschungsdiskussion um das Thema der judenchristlichen Beziehungen im Rom des 1. Jahrhunderts. Gegen die mehrheitliche Auffassung, dass Clemens eine...
Adapting the SHEL model in investigating industrial maintenance
Purpose – The purpose of this paper is to identify and categorise problems in knowledge management of industrial maintenance, and support successful maintenance through adapting the SHEL model. The SHEL model has been used...
Endovascular Treatment of Intracerebral Giant Cell Arteritis.
Claus Z Simonsen, Lasse Speiser, Ib Tønder Hansen, David Jayne, Paul von Weitzel-Mudersbach
Jun 22, 2020
Background: Giant cell arteritis (GCA) is the most common primary systemic vasculitis predominantly affecting large and medium sized vessels. In rare cases, the vasculitis can affect the vessels of the brain. Results: We...
Genetic risk of Parkinson disease and progression:
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J Hutten, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
May 03, 2019
Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry.
Lasse Staby, Katherine R Kemplen, Amelie Stein, Michael Ploug, Jane Clarke, Karen Skriver, Pétur O Heidarsson, Birthe B Kragelund
Sep 16, 2021
EF-hand Frequenin IDP NCS-1 Order–disorder interplay Protein Folding Amino Acid Sequence Binding Sites Carrier Proteins Humans Hydrophobic and Hydrophilic Interactions Intrinsically Disordered Proteins Kinetics Ligands Models Molecular Mutation Neuronal Calcium-Sensor Proteins Neuropeptides Protein Domains Protein Stability Thermodynamics
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.
Yuteng Wu, Lasse B Olsen, Yu Heng Lau, Claus Hatt Jensen, Maxim Rossmann, Ysobel R Baker, Hannah F Sore, Súil Collins, David R Spring
Mar 01, 2016
Differences in the Presentation and Progression of Parkinson's Disease by Sex.
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Mary B Makarious, Jonggeol J Kim, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Luba Smolensky, Ninad Amondikar, Samantha J Hutten, Mark Frasier, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, Raphael J Gibbs, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Ole A Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Aug 11, 2020
Genomic Steppe ancestry in skeletons from the Neolithic Single Grave Culture in Denmark.
Anne Friis-Holm Egfjord, Ashot Margaryan, Anders Fischer, Karl-Göran Sjögren, T Douglas Price, Niels N Johannsen, Poul Otto Nielsen, Lasse Sørensen, Eske Willerslev, Rune Iversen, Martin Sikora, Kristian Kristiansen, Morten E Allentoft
Mar 08, 2021
The Gjerrild burial provides the largest and best-preserved assemblage of human skeletal material presently known from the Single Grave Culture (SGC) in Denmark. For generations it has been debated among archaeologists if the...
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation.
Lasse Reimer, Hjalte Gram, Nanna Møller Jensen, Cristine Betzer, Li Yang, Lorrain Jin, Min Shi, Driss Boudeffa, Giuliana Fusco, Alfonso De Simone, Deniz Kirik, Hilal A Lashuel, Jing Zhang, Poul Henning Jensen
Mar 02, 2023
Aggregated α-synuclein (α-syn) accumulates in the neuronal Lewy body (LB) inclusions in Parkinson's disease (PD) and LB dementia. Yet, under nonpathological conditions, monomeric α-syn is hypothesized to exist in an equilibrium...
Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases
Killian Donovan, William G Herrington, Guillaume Paré, Marie Pigeyre, Richard Haynes, Rebecca Sardell, Adam S Butterworth, Lasse Folkersen, Stefan Gustafsson, Qin Wang, Colin Baigent, Anders Mälarstig, Michael V Holmes, Natalie Staplin, on behalf of the SCALLOP Consortium
Mar 03, 2023
BACKGROUND: Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian...
Genomic Steppe ancestry in skeletons from the Neolithic Single Grave Culture in Denmark
Anne Friis-Holm Egfjord, Ashot Margaryan, Anders Fischer, Karl-Göran Sjögren, T. Douglas Price, Niels N. Johannsen, Poul Otto Nielsen, Lasse Sørensen, Eske Willerslev, Rune Iversen, Martin Sikora, Kristian Kristiansen, Morten E. Allentoft
Jan 14, 2021
The Gjerrild burial provides the largest and best-preserved assemblage of human skeletal material presently known from the Single Grave Culture (SGC) in Denmark. For generations it has been debated among archaeologists if the...
An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia
Theis Zetner Trolle Jensen, Arne Sjöström, Anders Fischer, Erika Rosengren, Liam Thomas Lanigan, Ole Bennike, Kristine Korzow Richter, Kurt Joseph Gron, Meaghan Mackie, Morten Fischer Mortensen, Lasse Sørensen, David Chivall, Katrine Højholt Iversen, Alberto John Taurozzi, Jesper Olsen, Hannes Schroeder, Nicky Milner, Mikkel Sørensen, Matthew James Collins
Oct 14, 2020
Abstract: The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied....
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Jonggeol J Kim, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J Hutten, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, J Raphael Gibbs, International Parkinson's Disease Genomics Consortium, Kumaraswamy Naidu Chitrala, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Ole Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Jul 29, 2019
Apolipoprotein E GBA Parkinson's Disease genomewide association study Adult Aged Aged 80 and over Antigens CD Biomarkers Cognitive Dysfunction Cohort Studies Cross-Sectional Studies Disease Progression Female Genome-Wide Association Study Glucosylceramidase Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Longitudinal Studies Male Middle Aged Organic Cation Transport Proteins Parkinson Disease Phenotype Risk Assessment
An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia.
Theis Zetner Trolle Jensen, Arne Sjöström, Anders Fischer, Erika Rosengren, Liam Thomas Lanigan, Ole Bennike, Kristine Korzow Richter, Kurt Joseph Gron, Meaghan Mackie, Morten Fischer Mortensen, Lasse Sørensen, David Chivall, Katrine Højholt Iversen, Alberto John Taurozzi, Jesper Olsen, Hannes Schroeder, Nicky Milner, Mikkel Sørensen, Matthew James Collins
Sep 29, 2020
An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia
Theis Zetner Trolle Jensen, Arne Sjöström, Anders Fischer, Erika Rosengren, Liam Thomas Lanigan, Ole Bennike, Kristine Korzow Richter, Kurt Joseph Gron, Meaghan Mackie, Morten Fischer Mortensen, Lasse Sørensen, David Chivall, Katrine Højholt Iversen, Alberto John Taurozzi, Jesper Olsen, Hannes Schroeder, Nicky Milner, Mikkel Sørensen, Matthew James Collins
Oct 18, 2021
Abstract: The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied....
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.
Timothy R Hammond, Connor Dufort, Lasse Dissing-Olesen, Stefanie Giera, Adam Young, Alec Wysoker, Alec J Walker, Frederick Gergits, Michael Segel, James Nemesh, Samuel E Marsh, Arpiar Saunders, Evan Macosko, Florent Ginhoux, Jinmiao Chen, Robin Jm Franklin, Xianhua Piao, Steven A McCarroll, Beth Stevens
Dec 19, 2018
Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. Here, we analyzed the RNA expression...
activation Brain Demyelination development Diversity Glia Heterogeneity Injury Microglia single-cell RNA seq Adaptation Physiological aging Animals Brain Brain Injuries Cell Differentiation Demyelinating Diseases Humans longevity Mice Mice Inbred C57BL Microglia Multiple Sclerosis Sequence Analysis RNA Single-Cell Analysis
Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.
Katherine E Beaney, Andrew JP Smith, Lasse Folkersen, Jutta Palmen, S Goya Wannamethee, Barbara J Jefferis, Peter Whincup, Tom R Gaunt, Juan P Casas, Yoav Ben-Shlomo, Jacqueline F Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Mika Kivimaki, Per Eriksson, Steve E Humphries, Ucleb Consortium
Aug 16, 2017
Background. The coronary heart disease (CHD) risk locus on 21q22 (lead SNP rs9982601) lies within a "gene desert." The aim of this study was to assess if this locus is associated with CHD risk factors and to identify the...
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans.
Barbara Mühlemann, Ashot Margaryan, Peter de Barros Damgaard, Morten E Allentoft, Lasse Vinner, Anders J Hansen, Andrzej Weber, Vladimir I Bazaliiskii, Martyna Molak, Jette Arneborg, Wieslaw Bogdanowicz, Ceri Falys, Mikhail Sablin, Václav Smrčka, Sabine Sten, Kadicha Tashbaeva, Niels Lynnerup, Martin Sikora, Derek J Smith, Ron AM Fouchier, Christian Drosten, Karl-Göran Sjögren, Kristian Kristiansen, Eske Willerslev, Terry C Jones
Sep 05, 2018
Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among...
A Middle Pleistocene Denisovan molar from the Annamite Chain of northern Laos.
Fabrice Demeter, Clément Zanolli, Kira E Westaway, Renaud Joannes-Boyau, Philippe Duringer, Mike W Morley, Frido Welker, Patrick L Rüther, Matthew M Skinner, Hugh McColl, Charleen Gaunitz, Lasse Vinner, Tyler E Dunn, Jesper V Olsen, Martin Sikora, Jean-Luc Ponche, Eric Suzzoni, Sébastien Frangeul, Quentin Boesch, Pierre-Olivier Antoine, Lei Pan, Song Xing, Jian-Xin Zhao, Richard M Bailey, Souliphane Boualaphane, Phonephanh Sichanthongtip, Daovee Sihanam, Elise Patole-Edoumba, Françoise Aubaile, Françoise Crozier, Nicolas Bourgon, Alexandra Zachwieja, Thonglith Luangkhoth, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Enrico Cappellini, Anne-Marie Bacon, Jean-Jacques Hublin, Eske Willerslev, Laura Shackelford
May 18, 2022
The Pleistocene presence of the genus Homo in continental Southeast Asia is primarily evidenced by a sparse stone tool record and rare human remains. Here we report a Middle Pleistocene hominin specimen from Laos, with the...
A 2-million-year-old ecosystem in Greenland uncovered by environmental DNA.
Kurt H Kjær, Mikkel Winther Pedersen, Bianca De Sanctis, Binia De Cahsan, Thorfinn S Korneliussen, Christian S Michelsen, Karina K Sand, Stanislav Jelavić, Anthony H Ruter, Astrid MA Schmidt, Kristian K Kjeldsen, Alexey S Tesakov, Ian Snowball, John C Gosse, Inger G Alsos, Yucheng Wang, Christoph Dockter, Magnus Rasmussen, Morten E Jørgensen, Birgitte Skadhauge, Ana Prohaska, Jeppe Å Kristensen, Morten Bjerager, Morten E Allentoft, Eric Coissac, PhyloNorway Consortium, Alexandra Rouillard, Alexandra Simakova, Antonio Fernandez-Guerra, Chris Bowler, Marc Macias-Fauria, Lasse Vinner, John J Welch, Alan J Hidy, Martin Sikora, Matthew J Collins, Richard Durbin, Nicolaj K Larsen, Eske Willerslev
Dec 08, 2022
Ancient hepatitis B viruses from the Bronze Age to the Medieval period.
Barbara Mühlemann, Terry C Jones, Peter de Barros Damgaard, Morten E Allentoft, Irina Shevnina, Andrey Logvin, Emma Usmanova, Irina P Panyushkina, Bazartseren Boldgiv, Tsevel Bazartseren, Kadicha Tashbaeva, Victor Merz, Nina Lau, Václav Smrčka, Dmitry Voyakin, Egor Kitov, Andrey Epimakhov, Dalia Pokutta, Magdolna Vicze, T Douglas Price, Vyacheslav Moiseyev, Anders J Hansen, Ludovic Orlando, Simon Rasmussen, Martin Sikora, Lasse Vinner, Albert DME Osterhaus, Derek J Smith, Dieter Glebe, Ron AM Fouchier, Christian Drosten, Karl-Göran Sjögren, Kristian Kristiansen, Eske Willerslev
Sep 08, 2018
A 2-million-year-old ecosystem in Greenland uncovered by environmental DNA.
Kurt H Kjær, Mikkel Winther Pedersen, Bianca De Sanctis, Binia De Cahsan, Thorfinn S Korneliussen, Christian S Michelsen, Karina K Sand, Stanislav Jelavić, Anthony H Ruter, Astrid MA Schmidt, Kristian K Kjeldsen, Alexey S Tesakov, Ian Snowball, John C Gosse, Inger G Alsos, Yucheng Wang, Christoph Dockter, Magnus Rasmussen, Morten E Jørgensen, Birgitte Skadhauge, Ana Prohaska, Jeppe Å Kristensen, Morten Bjerager, Morten E Allentoft, Eric Coissac, PhyloNorway Consortium, Alexandra Rouillard, Alexandra Simakova, Antonio Fernandez-Guerra, Chris Bowler, Marc Macias-Fauria, Lasse Vinner, John J Welch, Alan J Hidy, Martin Sikora, Matthew J Collins, Richard Durbin, Nicolaj K Larsen, Eske Willerslev
Jan 07, 2023
Late Pliocene and Early Pleistocene epochs 3.6 to 0.8 million years ago1 had climates resembling those forecasted under future warming2. Palaeoclimatic records show strong polar amplification with mean annual temperatures of...
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