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Results: 16340
A global sampler of single particle tracking solutions for single molecule microscopy.
Michael Hirsch, Richard Wareham, Ji W Yoon, Daniel J Rolfe, Laura C Zanetti-Domingues, Michael P Hobson, Peter J Parker, Marisa L Martin-Fernandez, Sumeetpal S Singh
Sep 09, 2019
The dependence on model-fitting to evaluate particle trajectories makes it difficult for single particle tracking (SPT) to resolve the heterogeneous molecular motions typical of cells. We present here a global spatiotemporal...
Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress
Luiza Mendonça, Andrew Howe, James B. Gilchrist, Yuewen Sheng, Dapeng Sun, Michael L. Knight, Laura C. Zanetti-Domingues, Benji Bateman, Anna-Sophia Krebs, Long Chen, Julika Radecke, Vivian D. Li, Tao Ni, Ilias Kounatidis, Mohamed A. Koronfel, Marta Szynkiewicz, Maria Harkiolaki, Marisa L. Martin-Fernandez, William James, Peijun Zhang
Jul 30, 2021
Abstract: Since the outbreak of the SARS-CoV-2 pandemic, there have been intense structural studies on purified viral components and inactivated viruses. However, structural and ultrastructural evidence on how the SARS-CoV-2...
Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress.
Luiza Mendonça, Andrew Howe, James B Gilchrist, Yuewen Sheng, Dapeng Sun, Michael L Knight, Laura C Zanetti-Domingues, Benji Bateman, Anna-Sophia Krebs, Long Chen, Julika Radecke, Vivian D Li, Tao Ni, Ilias Kounatidis, Mohamed A Koronfel, Marta Szynkiewicz, Maria Harkiolaki, Marisa L Martin-Fernandez, William James, Peijun Zhang
Aug 31, 2021
Interview with the Daughters of Marjorie Faucett Patterson
Interview with Lynne Trowbridge and Laura Timmons, daughters of Marjorie Faucett Patterson, 1995 South Carolina Mother of the Year.
Published by: Winthrop University
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
From the King’s Hunt to the Ladies’ Cavalcade
Valerio Zanetti
Nov 27, 2019
Published by: The Court Historian
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.
Laura Torres-Garcia, Joana M P Domingues, Edoardo Brandi, Caroline Haikal, Janitha M Mudannayake, Inês C Brás, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F Outeiro, Gunnar K Gouras, Jia-Yi Li
Mar 28, 2022
Parkinson's disease (PD) and Alzheimer's disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD, and amyloid-β (Aβ) and Tau in AD. Strikingly...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
Laura Chuhan Campbell, The Medieval Merlin Tradition in France and Italy: Prophecy, Paradox, and “Translatio”. (Gallica.) Cambridge, UK: D. S. Brewer, 2017. Pp. viii, 211. £60. ISBN
Irène Fabry-Tehranchi
Feb 07, 2020
This book, a revised version of the author’s 2011 dissertation at the University of Durham, studies the reinterpretation of Merlin’s character in French and Italian Arthurian literature through the question of translation. Laura...
GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C.
Peace Atakpa, Laura M van Marrewijk, Michael Apta-Smith, Sumita Chakraborty, Colin W Taylor
Jan 30, 2019
The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes. We show that GPN evokes a...
Ca2+ signals Cathepsin C Cytosolic pH Endoplasmic Reticulum GPN lysosome Biological Transport CRISPR-Cas Systems Calcium Calcium Channels Calcium Signaling Cathepsin C Cell Line Tumor Cytosol Dipeptides Endoplasmic Reticulum Gene Editing Gene Expression Gene Knockdown Techniques HEK293 Cells HeLa Cells Humans Hydrogen-Ion Concentration Inositol 1 4 5-Trisphosphate Receptors Leukocytes Lysosome-Associated Membrane Glycoproteins Lysosomes Ploidies Ryanodine Receptor Calcium Release Channel
The ALPINE–ALMA [C ii] Survey
Abstract
We present the radio properties of 66 spectroscopically confirmed normal star-forming galaxies (SFGs) at 4.4 < z < 5.9 in the COSMOS field...
Lu Shen, Brian C Lemaux, Lori M Lubin, Guilin Liu, Matthieu Béthermin, Médéric Boquien, Olga Cucciati, Olivier Le Fèvre, Margherita Talia, Daniela Vergani, Gianni Zamorani, Andreas L Faisst, Michele Ginolfi, Carlotta Gruppioni, Gareth C Jones, Sandro Bardelli, Nimish Hathi, Anton M Koekemoer, Michael Romano, Daniel Schaerer, Elena Zucca, Wenjuan Fang, Ben Forrest, Roy Gal, Denise Hung, Ekta A Shah, Priti Staab, Brittany Vanderhoof, Eduardo Ibar
Aug 24, 2022
Vitamin C Cytotoxicity and Its Effects in Redox Homeostasis and Energetic Metabolism in Papillary Thyroid Carcinoma Cell Lines
Laura Tronci, Gabriele Serreli, Cristina Piras, Daniela Virginia Frau, Tinuccia Dettori, Monica Deiana, Federica Murgia, Maria Laura Santoru, Martina Spada, Vera Piera Leoni, Julian Leether Griffin, Roberta Vanni, Luigi Atzori, Paola Caria
May 21, 2021
High-dose of vitamin C (L-ascorbic acid, ascorbate) exhibits anti-tumoral effects, primarily mediated by pro-oxidant mechanisms. This cytotoxic effect is thought to affect the reciprocal crosstalk between redox balance and cell...
Vitamin C Cytotoxicity and Its Effects in Redox Homeostasis and Energetic Metabolism in Papillary Thyroid Carcinoma Cell Lines.
Laura Tronci, Gabriele Serreli, Cristina Piras, Daniela Virginia Frau, Tinuccia Dettori, Monica Deiana, Federica Murgia, Maria Laura Santoru, Martina Spada, Vera Piera Leoni, Julian Leether Griffin, Roberta Vanni, Luigi Atzori, Paola Caria
Jul 07, 2021
High-dose of vitamin C (L-ascorbic acid, ascorbate) exhibits anti-tumoral effects, primarily mediated by pro-oxidant mechanisms. This cytotoxic effect is thought to affect the reciprocal crosstalk between redox balance and cell...
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
Roland Jäger, Gabriele Migliorini, Marc Henrion, Radhika Kandaswamy, Helen E Speedy, Andreas Heindl, Nicola Whiffin, Maria J Carnicer, Laura Broome, Nicola Dryden, Takashi Nagano, Stefan Schoenfelder, Martin Enge, Yinyin Yuan, Jussi Taipale, Peter Fraser, Olivia Fletcher, Richard S Houlston
Jul 15, 2019
Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide...
The Multifunctional Capsid Gene of Hepatitis C Virus
Laura Katherine McMullan
Jan 01, 0001
In populations worldwide, the Hepatitis C Virus displays great diversity. The capsid gene, however, is remarkably conserved and this has led to predictions of RNA secondary structure and an overlapping, alternative reading frame...
Published by: Rockefeller University
Search for the doubly heavy baryons Ω<inf>bc</inf><sup>0</sup>and Ξ<inf>bc</inf><sup>0</sup>decaying to Λ<inf>c</inf><sup>+</sup>π- And Ξ<inf>c</inf><sup>+</sup>π- And c
C Nguyen-Mau, R Aaij, C Abellán Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, G Alkhazov, P Alvarez Cartelle, S Amato, Y Amhis, L An, L Anderlini, A Andreianov, M Andreotti, F Archilli, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, M Bachmayer, JJ Back, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista Leite, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, JM Basels, G Bassi, B Batsukh, A Battig, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, V Belavin, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, I Bezshyiko, S Bhasin, J Bhom, L Bian, MS Bieker, S Bifani, P Billoir, M Birch, FCR Bishop, A Bitadze, A Bizzeti, M Bj rn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, JA Boelhauve, O Boente Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, SA Bouchiba, TJV Bowcock, A Boyer, C Bozzi, MJ Bradley
Aug 31, 2021
The first search for the doubly heavy $\it{\Omega}_{bc}^{\rm0}$ baryon and a
search for $\it{\Xi}_{bc}^{\rm0}$ baryon are performed using $pp$ collision
data collected via the LHCb experiment from 2016 to 2018 at a...
Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage.
As a readily available feedstock, styrene with about 25 million tons of global annual production serves as an important building block and organic synthon for the synthesis of fine chemicals, polystyrene plastics, and...
New C∧N∧C Bis-Cyclometalated Platinum(II) Complexes
Sara Fuertes Lorda, Simon K Brayshaw, Paul R Raithby, Stefanie Schiffers, Mark R Warren
Jan 01, 0001
The reaction of a new ligand, ethyl 2,6-diphenylisonicotinate (EtO(2)C-CAN boolean AND C-H(2)), with K(2)PtCl(4) in acetic acid affords the monocyclometalated complex [{(EtO(2)C-CANAC-H)Pt(mu-Cl)}(2)] (1), which transforms to...
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