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Results: 150
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.
Hepatocyte nuclear factor-1β (HNF1β) Importin-α Isothermal titration calorimetry Nuclear import pathway Nuclear localisation signal sequence (NLS) Site-directed mutagenesis X-ray crystallography Active Transport Cell Nucleus Animals Binding Sites Cell Line Tumor Cell Nucleus Crystallography X-Ray HEK293 Cells Hepatocyte Nuclear Factor 1-beta Humans Mice Models Molecular Nuclear Localization Signals Protein Binding Protein Conformation alpha-Helical Sequence Analysis Protein Xenopus Proteins Xenopus laevis alpha Karyopherins
Springboard, not roadblock
The age of migration finds its physical manifestation in the immigrant neighbourhoods of European cities. These ‘ethnic enclaves’ have received much attention from the public, as well as policy makers. Conventional...
Lena Hafner
Jun 07, 2022
Ethical Dilemmas and Big Data
Using big data in organizations has the potential to improve innovation, accuracy, and efficiency. Big data is also connected with risks for both the organization and society at large. It is therefore vital to improve our...
Published by: IGI Global Scientific Publishing
Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
Maria Cristina Piro, Alessandra Ventura, Artem Smirnov, Andrea Saggini, Anna Maria Lena, Alessandro Mauriello, Luca Bianchi, Gerry Melino, Eleonora Candi
May 15, 2020
Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we...
Components Required for the Death and Degradation of the Linker Cell in C. Elegans
Lena Marlise Kutscher
Jan 01, 0001
Programmed cell death (PCD) is an important process in the development of multicellular organisms. Apoptosis, a form of PCD characterized morphologically by chromatin condensation, membrane blebbing, and cytoplasm compaction...
Published by: Rockefeller University
Couple relationship quality and the infant home language environment
Couple relationship quality is known to drop significantly across the transition to parenthood (Ahlborg & Strandmark, 2001; Doss, Rhoades, Stanley, & Markman, 2009), yet individual differences in the amount of parent-to-infant...
The Effects of Price Regulation on Pharmaceutical R&D and Innovation
As rising health care expenditures focus government attention on slowing the growth, the pharmaceutical industry comes under increasing pressure to curb prices of ethical drugs. Pharmaceutical price regulations have been...
Japan drug exports patent protection profit regulation imitative Generics new molecular entities new chemical entities new biologic entities new active substances efficacy standards Clinical Trials mergers Business Economics Food and Drug Law Organizational Behavior and Theory Pharmacoeconomics and Pharmaceutical Economics
Published by: Ursinus College
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.
Gretchen Wolff, Minako Sakurai, Amit Mhamane, Maria Troullinaki, Adriano Maida, Ioannis K Deligiannis, Kelvin Yin, Peter Weber, Jakob Morgenstern, Annika Wieder, Yun Kwon, Revathi Sekar, Anja Zeigerer, Michael Roden, Matthias Blüher, Nadine Volk, Tanja Poth, Thilo Hackert, Lena Wiedmann, Francesca De Angelis Rigotti, Juan Rodriguez-Vita, Andreas Fischer, Rajesh Mukthavaram, Pattraranee Limphong, Kiyoshi Tachikawa, Priya Karmali, Joseph Payne, Padmanabh Chivukula, Bilgen Ekim-Üstünel, Celia P Martinez-Jimenez, Julia Szendrödi, Peter Nawroth, Stephan Herzig
May 09, 2022
OBJECTIVE: Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic...
Fifteen-minute consultation
The identification of an abdominal mass in a child, either coincidental or symptomatic, may be due to a tumour. An abdominal tumour may present with life-threatening symptoms, requiring prompt assessment and management. Although...
The relation between memory and decision-making in Multiple Sclerosis patients
Background. Impairments in long-term and working memory are widespread in Multiple Sclerosis (MS), setting on in early disease stages. These memory impairments may limit patients’ ability to take informed and competent medical...
The Ursinus Weekly, January 12, 1925
Lena Carl elected to captain 1925 hockey team by 1924 varsity Dean E. B. White wins American Historical Association prize Varsity yields before last-half rally of Swarthmore Junior varsity is given hard jolt by Perkiomen...
Ursinus College Collegeville Pennsylvania newspaper Football Elizabeth B. White field hockey Basketball debate team Zwinglian literary society Schaff literary society crossword puzzles cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Equal accuracy for Andrew and Abubakar-detecting and mitigating bias in name-ethnicity classification algorithms.
UNLABELLED: Uncovering the world's ethnic inequalities is hampered by a lack of ethnicity-annotated datasets. Name-ethnicity classifiers (NECs) can help, as they are able to infer people's ethnicities from their names. However...
Dimensional Expressivity Analysis, best-approximation errors, and automated design of parametric quantum circuits
Lena Funcke, Tobias Hartung, Karl Jansen, Stefan Kühn, Manuel Schneider, Paolo Stornati
Jul 08, 2022
The design of parametric quantum circuits (PQCs) for efficient use in variational quantum simulations (VQS) is subject to two competing factors. On one hand, the set of states that can be generated by the PQC has to be large...
The relation between memory and decision-making in Multiple Sclerosis patients
Background. Impairments in long-term and working memory are widespread in Multiple Sclerosis (MS), setting on in early disease stages. These memory impairments may limit patients’ ability to take informed and competent medical...
Urinary Excretion of Silicon in Men, Non-pregnant Women, and Pregnant Women
Catarina Magnusson, Ravin Jugdaohsingh, Lena Hulthen, Anna Westerlund, Jonathan J Powell, Maria Ransjö
Mar 26, 2020
Silicon is a trace element found mainly in plant-based food and proposed to be beneficial for bone health. Urinary excretion of Si has been shown to be a surrogate measure of its uptake in the gastrointestinal tract. The...
Dimensional Expressivity Analysis, best-approximation errors, and automated design of parametric quantum circuits
Lena Funcke, Tobias Hartung, Karl Jansen, Stefan Kühn, Manuel Schneider, Paolo Stornati
Jul 08, 2022
The design of parametric quantum circuits (PQCs) for efficient use in variational quantum simulations (VQS) is subject to two competing factors. On one hand, the set of states that can be generated by the PQC has to be large...
No correlation between estimated and actual glomerular filtration rates in pediatric oncology patients.
This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1002/pbc.25490
Assessment of Cardiovascular Risk in Women
Cardiovascular disease is the leading cause of death in women worldwide. Nonetheless, there exist several uncertainties in the prediction, diagnosis, and treatment of cardiovascular disease in women. A cornerstone in the...
Urinary Excretion of Silicon in Men, Non-pregnant Women, and Pregnant Women
Catarina Magnusson, Ravin Jugdaohsingh, Lena Hulthen, Anna Westerlund, Jonathan J. Powell, Maria Ransjö
Jun 06, 2020
Abstract: Silicon is a trace element found mainly in plant-based food and proposed to be beneficial for bone health. Urinary excretion of Si has been shown to be a surrogate measure of its uptake in the gastrointestinal tract....
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
Mareike M Wiedmann, Yaw Sing Tan, Yuteng Wu, Shintaro Aibara, Wenshu Xu, Hannah F Sore, Chandra S Verma, Laura Itzhaki, Murray Stewart, James D Brenton, David R Spring
Nov 10, 2017
There is a lack of current treatment options for ovarian clear cell carcinoma (CCC) and the cancer is often resistant to platinum-based chemotherapy. Hence there is an urgent need for novel therapeutics. The transcription factor...
Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars.
Luise Krüger, Milena Stillfried, Carolin Prinz, Vanessa Schröder, Lena Katharina Neubert, Joachim Denner
Apr 09, 2020
Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in...
Psychological Network Analysis of General Self-Efficacy in High vs. Low Resilient Functioning Healthy Adults.
Katja Schueler, Jessica Fritz, Lena Dorfschmidt, Anne-Laura van Harmelen, Eike Stroemer, Michèle Wessa
Dec 15, 2021
Resilience to stress has gained increasing interest by researchers from the field of mental health and illness and some recent studies have investigated resilience from a network perspective. General self-efficacy constitutes an...
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