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Giovanni Canestrini’s models of Leonardo da Vinci’s friction experiments
IM Hutchings
Feb 16, 2017
Among the exhibits at the 2016 Leonardo da Vinci exhibition at the Science Museum, London, was one that purported to illustrate Leonardo’s experiments on friction. The models involved were the work of Giovanni Canestrini...
ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis.
Colombia's Fork in the Road? President Santos' Treaty with The Revolutionary Armed Forces of Colombia (FARC)
Ella Adriana Chirinos
Aug 22, 2017
Colombia is considered Latin America’s most stable democracy; meanwhile, it is war-torn by the internal conflict with the guerrilla group, the Revolutionary Armed Forces of Colombia (FARC). The armed conflict with the FARC has...
Published by: Memorial University of Newfoundland
Colombia's Fork in the Road? President Santos' Treaty with The Revolutionary Armed Forces of Colombia (FARC)
Ella Adriana Chirinos
Aug 22, 2017
Colombia is considered Latin America’s most stable democracy; meanwhile, it is war-torn by the internal conflict with the guerrilla group, the Revolutionary Armed Forces of Colombia (FARC). The armed conflict with the FARC has...
Published by: Memorial University of Newfoundland
Fitness but not weight status is associated with projected physical independence in older adults.
Biocultural predictors of motor coordination among pre-pubertal boys and girls
Leonardo Luz, João Valente-dos-Santos, Tatiana Luz, Paulo Sousae-e-Silva, João P. Duarte, Aristides Machado-Rodrigues, Andre Seabra, Rute Santos, Sean P. Cumming, Manuel J. Coelho-e-Silva
Feb 01, 2018
This study aimed to predict motor coordination from a matrix of biocultural factors. The sample included 173 children (89 boys, 84 girls) aged 7-9 years assessed on the Körperkoordinationtest für Kinder test battery....
Blowups with log canonical singularities
We show that the minimum weight of a weighted blowup of Ad with ε–log canonical singularities is bounded by a constant depending only on ε and d . This was conjectured by Birkar. Using the recent classification of...
Effects of dietary intake patterns from 1 to 4 years on BMI z-score and body shape at age of 6 years
PURPOSE: To assess the association between dietary intake patterns from 1 to 4 years and BMI and body shape at age of 6 years. METHODS: This longitudinal study was based on 3374 Brazilian children from the 2004 Pelotas Birth...
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O'Donovan, Kilian VM Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
May 26, 2020
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable...
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O'Donovan, Kilian V M Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
Jul 28, 2021
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable...
Published by: Chemical science
Ancestral chromosomal signatures of Paenungulata (Afroteria) reveal the karyotype of Amazonian manatee (Trichechus inunguis, Sirenia
Flávia Dos Santos Tavares, Willam Oliveira da Silva, Malcolm Andrew Ferguson-Smith, Alex Garcia Cavalleiro de Macedo Klautau, Jairo Moura Oliveira, Angélica Lúcia Figueiredo Rodrigues, Gabriel Melo-Santos, Julio Cesar Pieczarka, Cleusa Yoshiko Nagamachi, Renata Coelho Rodrigues Noronha
Jan 24, 2023
BACKGROUND: Chromosomal painting in manatees has clarified questions about the rapid evolution of sirenians within the Paenungulata clade. Further cytogenetic studies in Afrotherian species may provide information about their...
Biocultural predictors of motor coordination among pre-pubertal boys and girls
Leonardo Luz, João Valente-dos-Santos, Tatiana Luz, Paulo Sousae-e-Silva, João P. Duarte, Aristides Machado-Rodrigues, Andre Seabra, Rute Santos, Sean P. Cumming, Manuel J. Coelho-e-Silva
Feb 01, 2018
This study aimed to predict motor coordination from a matrix of biocultural factors. The sample included 173 children (89 boys, 84 girls) aged 7-9 years assessed on the Körperkoordinationtest für Kinder test battery....
Blowups with log canonical singularities
We show that the minimum weight of a weighted blowup of Ad with ε–log canonical singularities is bounded by a constant depending only on ε and d . This was conjectured by Birkar. Using the recent classification of...
A Multi-Criteria Decision-Making Model for Selecting a Maturity Model
This paper proposes a decision model for a maturity model choice problem via the multiple-criteria decision analysis method. The authors implemented the model in FITradeoff decision support system to select a project management...
Published by: IGI Global Scientific Publishing
Hybridization between subterranean tuco-tucos (Rodentia, Ctenomyidae) with contrasting phylogenetic positions
Bruno Busnello Kubiak, Rafael Kretschmer, Leonardo Trindade Leipnitz, Renan Maestri, Thamara Santos de Almeida, Leandro Rodrigues Borges, Daniel Galiano, Jorge C. Pereira, Edivaldo Herculano Corrêa de Oliveira, Malcolm A. Ferguson-Smith, Thales Renato Ochotorena de Freitas
Jan 29, 2021
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export
Lydia M Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A Myszczynska, Paul R Heath, Matthew R Livesey, Ke Ning, Mimoun Azzouz, Pamela J Shaw, Mario R Guarracino, Alexander J Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M Hautbergue
Sep 11, 2021
Background
Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the...
Transcriptome Amyotrophic Lateral Sclerosis Pre-clinical models Voltage-gated potassium ion channel Genome-wide mechanisms of neuroprotection SRSF1-dependent RNA nuclear export C9ORF72-repeat expansions Disease-modifying gene expression signature
Published by: Molecular neurodegeneration
Comparative genomic mapping reveals mechanisms of chromosome diversification in Rhipidomys species (Rodentia, Thomasomyini) and syntenic relationship between species of Sigmodontinae
Vergiana dos Santos Paixão, Pablo Suárez, Willam Oliveira da Silva, Lena Geise, Malcolm Andrew Ferguson-Smith, Patricia Caroline Mary O’Brien, Ana Cristina Mendes-Oliveira, Rogério Vieira Rossi, Julio Cesar Pieczarka, Cleusa Yoshiko Nagamachi
Oct 11, 2021
Rhipidomys (Sigmodontinae, Thomasomyini) has 25 recognized species, with a wide distribution ranging from eastern Panama to northern Argentina. Cytogenetic data has been described for 13 species with 12 of them having 2n = 44...
Hybridization between subterranean tuco-tucos (Rodentia, Ctenomyidae) with contrasting phylogenetic positions.
Bruno Busnello Kubiak, Rafael Kretschmer, Leonardo Trindade Leipnitz, Renan Maestri, Thamara Santos de Almeida, Leandro Rodrigues Borges, Daniel Galiano, Jorge C Pereira, Edivaldo Herculano Corrêa de Oliveira, Malcolm A Ferguson-Smith, Thales Renato Ochotorena de Freitas
Mar 02, 2020
Reproductive compatibility usually decreases according to increasing genetic difference and the time of divergence between species. However, the amount of modification required to influence hybridization may vary in different...
Published by: Scientific reports
Mycorrhizal fungi arbuscular in forage grasses cultivated in Cerrado soil
Mycorrhizal fungi arbuscular in forage grasses cultivated in Cerrado soil.
Comparative genomic mapping reveals mechanisms of chromosome diversification in Rhipidomys species (Rodentia, Thomasomyini) and syntenic relationship between species of Sigmodontinae.
Vergiana dos Santos Paixão, Pablo Suárez, Willam Oliveira da Silva, Lena Geise, Malcolm Andrew Ferguson-Smith, Patricia Caroline Mary O'Brien, Ana Cristina Mendes-Oliveira, Rogério Vieira Rossi, Julio Cesar Pieczarka, Cleusa Yoshiko Nagamachi
Nov 18, 2021
Rhipidomys (Sigmodontinae, Thomasomyini) has 25 recognized species, with a wide distribution ranging from eastern Panama to northern Argentina. Cytogenetic data has been described for 13 species with 12 of them having 2n = 44...
Paracetamol Is Associated with a Lower Risk of COVID-19 Infection and Decreased ACE2 Protein Expression
Ibuprofen is a common over-the-counter drug taken for pain relief. However, recent studies have raised concerns about its potential toxic effect with coronavirus disease 2019 (COVID-19), which is caused by severe acute...
Direitos Sociais na Constituição Uma Análise da Constitucionalização dos Direitos Sociais em Portugal, 1975-76
Embora todas as constituições incluam direitos, e muitas delas incluam direitos sociais, a verdade é que algumas são mais generosas do que outras a este respeito. Mas nenhuma se aproxima da Constituição da República Portuguesa...
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