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Autophagy at the intersection of aging, senescence, and cancer.
Autophagy is an evolutionarily conserved cellular process in which macromolecules undergo lysosomal degradation. It fulfills essential roles in quality controlling cellular constituents and in energy homeostasis. Basal autophagy...
Dynamic modulation of autophagy
Reduced autophagy has been implicated in aging, yet whether its loss can promote aging phenotypes and pathologies in mammals, and how reversible this process is, has never been fully explored. Using inducible short hairpin RNA...
Charlotte Magazine Names Shaun Cassidy Best Artist on Charlotte Scene
Winthrop University
Jan 01, 0001
Cassidy's newest exhibition, "The Sound of Everything," is on display through July 16 in the Ross Gallery at Central Piedmont Community College. Who's the best artist on the Charlotte, North Carolina, arts scene? Winthrop...
Published by: Winthrop University
Chromosome instability and carcinogenesis
Chromosomal instability is a hallmark of human cancer cells, but its role in carcinogenesis remains poorly resolved. Insights into this role have emerged from studies on the tumour suppressor BRCA2, whose inactivation in human...
BRCA2 chromosomal instability genetically engineered mouse model Hereditary cancer predisposition pancreatic cancer Animals BRCA2 Protein Cell Transformation Neoplastic chromosomal instability Chromosomes Human DNA Repair DNA Replication DNA Neoplasm Germ-Line Mutation Humans Mice Neoplasms Experimental Pancreatic Neoplasms
Kinard Teaching Award Goes to Sculpture Professor
Winthrop University
Jan 01, 0001
Sculpture professor Shaun Cassidy is the recipient of the 2006 Kinard Teaching Award. Cassidy is coordinator of the Department of Art and Design's sculpture program.
Published by: Winthrop University
Incorporating Academic Blogging into a Fifth Grade Classroom: Integrating Technology and Science into Literacy Instruction
Cassidy Tallman
Jan 01, 0001
There is a growing need to better prepare students for twenty-first-century literacy demands. Integrating technology into education improves student achievement and increases students' technological literacy. Classroom blogging...
Curriculum and Instruction Early Childhood Education Education Elementary Education Instructional Media Design Language and Literacy Education
Published by: Winthrop University
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance.
Sumter Exhibition to Feature Collaborative, Individual Works by Winthrop Faculty
Winthrop University
Jan 01, 0001
"Collaboration of Fragments" will open Nov. 19 at the Sumter County Gallery of Art. The exhibition will feature the collaborative and individual efforts of Winthrop faculty Tom Stanley and Shaun Cassidy.
Published by: Winthrop University
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
Liam D Cassidy, Andrew R J Young, Christopher N J Young, Elizabeth J Soilleux, Edward Fielder, Bettina M Weigand, Anthony Lagnado, Rebecca Brais, Nicholas T Ktistakis, Kimberley A Wiggins, Katerina Pyrillou, Murray C H Clarke, Diana Jurk, Joao F Passos, Masashi Narita
Feb 19, 2020
Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age...
Published by: Nature Communications
ASC Grants Prompt Artistic Exploration for Faculty, Staff, Alumni
Winthrop University
Jan 01, 0001
Two faculty/staff members received grants: Shaun Cassidy and Chris O'Neill '98, '10. Two alumni received grants: Holly Glasscock '86 and Betsy Birkner '97.
Published by: Winthrop University
A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.
Liam D Cassidy, Andrew RJ Young, Pedro A Pérez-Mancera, Birgit Nimmervoll, Adil Jaulim, Hung-Chang Chen, Dominick JO McIntyre, Rebecca Brais, Thomas Ricketts, Simon Pacey, Maike de la Roche, Richard J Gilbertson, David C Rubinsztein, Masashi Narita
Feb 14, 2018
Macroautophagy/autophagy is an evolutionarily conserved catabolic pathway whose modulation has been linked to diverse disease states, including age-associated disorders. Conventional and conditional whole-body knockout mouse...
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
Liam D. Cassidy, Andrew R. J. Young, Christopher N. J. Young, Elizabeth J. Soilleux, Edward Fielder, Bettina M. Weigand, Anthony Lagnado, Rebecca Brais, Nicholas T. Ktistakis, Kimberley A. Wiggins, Katerina Pyrillou, Murray C. H. Clarke, Diana Jurk, Joao F. Passos, Masashi Narita
Jan 15, 2021
Abstract: Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with...
Fine Arts Department and City of Rock Hill Team Up for City Artwork
Winthrop University
Jan 01, 0001
The project is made possible through a $30,000 grant from the National Endowment for the Arts grant. Professor of Fine Arts Shaun Cassidy will incorporate the project into a spring 2016 course.
Published by: Winthrop University
Art Professors Plan Mural Installation in Simpsonville
Winthrop University
Jan 01, 0001
Tom Stanley, director of Winthrop Galleries, and Sculpture Professor Shaun Cassidy will help install a mural in Simpsonville, S.C.
Published by: Winthrop University
Profiling lung adenocarcinoma by liquid biopsy
Harry W Clifford, Amy P Cassidy, Courtney Vaughn, Evaline S Tsai, Bianka Seres, Nirmesh Patel, Hannah L O'Neill, Emil Hewage, John W Cassidy
Dec 16, 2016
BACKGROUND: Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatment...
Matthews, N.C., Sports Complex Displays Winthrop Art
Winthrop University
Jan 01, 0001
Time Further Out stands 25 feet tall and is made of powder-coated steel and aluminum. Cassidy and Stanley have worked together before, most recently on the LYNX Blue Line Extension Project.
Published by: Winthrop University
Proposed Art for LYNX Blue Line Extension Highlights Professors' Works
Winthrop University
Jan 01, 0001
Tom Stanley and Shaun Cassidy are featured in the LYNX Blue Line Extension art project. An opening reception is scheduled for today at 5:30 p.m. at the Storrs Building Gallery in Charlotte. The exhibit will remain at the Storrs...
Published by: Winthrop University
Overseas Travel Inspires 'The Sound of Everything'
Winthrop University
Jan 01, 0001
Cassidy's lecture is scheduled for Thursday, April 16, at 6 p.m. in Tate Hall. "The Sound of Everything" will be on display through July 16. Trips to England and Wales inspired a new exhibit for Winthrop University Professor of...
Published by: Winthrop University
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