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The neurobiology of addiction
Cannabis-dependent adolescents show differences in global reward-associated network topology
Adolescence may be a period of increased vulnerability to the onset of drug misuse and addiction due to changes in developing brain networks that support cognitive and reward processing. Cannabis is a widely misused illicit drug...
Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.
Liam R Wilson, Deniz Vatansever, Tiina Annus, Guy B Williams, Young T Hong, Tim D Fryer, Peter J Nestor, Anthony J Holland, Shahid H Zaman
Jul 10, 2019
Down's syndrome is a chromosomal disorder that invariably results in both intellectual disability and Alzheimer's disease neuropathology. However, only a limited number of studies to date have investigated intrinsic brain...
Alzheimer's Disease Down's syndrome anti-correlation Default mode network functional connectivity Memory Adult Alzheimer Disease Amyloid Aniline Compounds Carbon Radioisotopes Cerebral Cortex Connectome Cross-Sectional Studies Down Syndrome Female Humans Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals Thiazoles
Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.
Elijah Mak, Concepcion Padilla, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
Mar 07, 2019
Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.
James H Cole, Tiina Annus, Liam R Wilson, Ridhaa Remtulla, Young T Hong, Tim D Fryer, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Robert Smith, David K Menon, Shahid H Zaman, Peter J Nestor, Anthony J Holland
Apr 06, 2018
Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome
Elijah Mak, Anastasia Bickerton, Concepcion Padilla, Madeleine J Walpert, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Bradley T Christian, Benjamin L Handen, William E Klunk, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
May 23, 2019
Alzheimer's Disease Down Syndrome Neurosciences Dementia Neurodegenerative Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Acquired Cognitive Impairment Biomedical Imaging aging Brain Disorders Intellectual and Developmental Disabilities (IDD) 2.1 Biological and endogenous factors 2 Aetiology Neurological
Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene
Hisham Ziauddeen, Liam J Nestor, Naresh Subramaniam, Chris Dodds, Pradeep J Nathan, Sam R Miller, Bhopinder K Sarai, Kay Maltby, Disala Fernando, Liling Warren, Louise K Hosking, Dawn Waterworth, Anna Korzeniowska, Beta Win, Duncan B Richards, Lakshmi Vasist Johnson, Paul C Fletcher, Edward T Bullmore
Apr 22, 2016
Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task.
Liam J Nestor, Anna Murphy, John McGonigle, Csaba Orban, Laurence Reed, Eleanor Taylor, Remy Flechais, Louise M Paterson, Dana Smith, Edward T Bullmore, Karen D Ersche, John Suckling, Roger Tait, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne Lingford-Hughes, David J Nutt, Barbara Sahakian, Trevor W Robbins, ICCAM Consortium
Feb 16, 2017
Disturbances across whole brain networks during reward anticipation in an abstinent addiction population.
Liam J Nestor, John Suckling, Karen D Ersche, Anna Murphy, John McGonigle, Csaba Orban, Louise M Paterson, Laurence Reed, Eleanor Taylor, Remy Flechais, Dana Smith, Edward T Bullmore, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne-Lingford Hughes, Barbara J Sahakian, Trevor W Robbins, David J Nutt, ICCAM Consortium
Jun 19, 2020
The prevalent spatial distribution of abnormalities reported in cognitive fMRI studies in addiction suggests there are extensive disruptions across whole brain networks. Studies using resting state have reported disruptions in...
Cost-effectiveness of cognitive therapy as an early intervention for post-traumatic stress disorder in children and adolescents
James Shearer, Nestor Papanikolaou, Richard Meiser-Stedman, Anna McKinnon, Tim Dalgleish, Patrick Smith, Clare Dixon, Sarah Byford
Apr 13, 2018
BACKGROUND: Untreated post-traumatic stress disorder (PTSD) in children and adolescents is associated with a considerable economic burden on the health system, families and society. Recent research has demonstrated the potential...
economic evaluation Cognitive Therapy Post-traumatic stress disorder Adolescent Child Cognitive Behavioral Therapy Cost-Benefit Analysis Early Medical Intervention Female Follow-Up Studies Humans Male Models Econometric Outcome Assessment Health Care Quality-Adjusted Life Years Stress Disorders Post-Traumatic
The pattern of amyloid accumulation in the brains of adults with Down syndrome.
Tiina Annus, Liam R Wilson, Young T Hong, Julio Acosta-Cabronero, Tim D Fryer, Arturo Cardenas-Blanco, Robert Smith, Istvan Boros, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Shahid H Zaman, Peter J Nestor, Anthony J Holland
Aug 18, 2015
Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome
Elijah Mak, Anastasia Bickerton, Concepcion Padilla, Madeleine J Walpert, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Bradley T Christian, Benjamin L Handen, William E Klunk, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
Feb 07, 2020
Introduction:Comorbid Alzheimer disease pathologies are frequently found in people with Down syndrome (DS). We report a deep phenotyping study undertaken over 7 years in a participant with DS who was nondemented at baseline but...
Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals.
Liam J Nestor, Louise M Paterson, Anna Murphy, John McGonigle, Csaba Orban, Laurence Reed, Eleanor Taylor, Remy Flechais, Dana Smith, Edward T Bullmore, Karen D Ersche, John Suckling, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne Lingford Hughes, Barbara J Sahakian, Trevor W Robbins, David J Nutt, ICCAM Consortium
Dec 03, 2018
Magnetoencephalography of frontotemporal dementia
Behavioural variant frontotemporal dementia is a neurodegenerative disorder with dysfunction and atrophy of the frontal lobes leading to changes in personality, behaviour, empathy, social conduct and insight, with relative...
Impulsivity in abstinent alcohol and polydrug dependence
Eleanor M Taylor, Anna Murphy, Venkat Boyapati, Karen D Ersche, Remy Flechais, Shankar Kuchibatla, John McGonigle, Anotonio Metastasio, Liam Nestor, Csaba Orban, Fillippo Passetti, Louise Paterson, Dana Smith, John Suckling, Roger Tait, Anne R Lingford-Hughes, Trevor W Robbins, David J Nutt, JF William Deakin, Rebecca Elliott, ICCAM Platform
Mar 10, 2016
Universal p‐ary designs
Liam Jolliffe
May 29, 2021
An Exploration of the Relationships Between Different Reading Strategies and IELTS Test Performance
This study explores which types of IELTS Academic Reading strategies are used, and the impact of these strategies on test outcomes. The study was a quantitative research, using descriptive-correlational design based on data...
Published by: IGI Global Scientific Publishing
What's "up"? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy.
This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients...
A Semi-Automated Data Pipeline for Predicting Lunar Impactor Diameters From Pre-Impact Topography and Ray Geometry
Liam Powers
Jan 01, 0001
The cause of asymmetries in ray systems created by impact craters has long remained a mystery. Sabuwala et al. (2018) showed that a relation exists between the creation of prominent rays, impactor diameter, and the number of...
lunar craters data automation elevation profiles ray geometry Physical Sciences and Mathematics Physics
Published by: Ursinus College
The Spatial Relationship Between Tycho Secondary Craters and Distal Impact Melt Deposits
Liam Powers
Jan 01, 0001
Study and analysis of Tycho's secondary crater populations in relation to previously identified impact melt and ray systems.
Published by: Ursinus College
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