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Results: 1372
Investigating Epistemic Stances in Game Play with Data Mining
In this paper, techniques of statistical computing were applied to data logs to investigate the patterns in students' play of The Fuzzy Chronicles, and how these patterns relate to learning outcomes with regards to Newtonian...
Published by: IGI Global Scientific Publishing
Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma
Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa
Mar 05, 2021
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal...
Dispersal and dispossession as bordering
Dispersal has acquired an increasingly central role within state-led border
control strategies in Europe and North Africa. Scholars have, however, tended
to apprehend dispersal in its geographical dimension, failing to...
Robustness of radiomic features in CT images with different slice thickness, comparing liver tumour and muscle
Lorena Escudero Sanchez, Leonardo Rundo, Andrew B. Gill, Matthew Hoare, Eva Mendes Serrao, Evis Sala
Apr 15, 2021
Abstract: Radiomic image features are becoming a promising non-invasive method to obtain quantitative measurements for tumour classification and therapy response assessment in oncological research. However, despite its...
Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma.
Esperanza M Algarín, Dalia Quwaider, Francisco J Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M Ocio, Mercedes Garayoa
May 17, 2021
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal...
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells.
Vladimir Shapovalov, Liliya Kopanitsa, Lavinia-Lorena Pruteanu, Graham Ladds, David S Bailey
Oct 11, 2021
We have used three established human glioblastoma (GBM) cell lines-U87MG, A172, and T98G-as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase...
The structural and functional determinants of the Axin and Dishevelled DIX domains.
Adaptor Proteins Signal Transducing Amino Acid Sequence Animals Axin Protein Dimerization Dishevelled Proteins evolution Molecular Humans Molecular Sequence Data Mutation Phenotype Phosphoproteins Protein Interaction Domains and Motifs Protein Structure Tertiary Rats Repressor Proteins Sequence Alignment
The Investigation of Dependence Between the Internet Measurement and Globalization
Under the new measurement for the internet supplied from the Cooperative Association for Internet Data Analysis (CAIDA), the authors relax the orthogonal and normality condition with the methodology based on empirical...
Published by: IGI Global Scientific Publishing
Incorporation of bacteria in concrete
Strength improvement of cement-based materials by the addition of bacteria has been reported over the past decade and has been mainly attributed to microbially induced calcite precipitation (MICP 1). However, the...
Migration policy and international human rights frameworks in Morocco
In 2013, Morocco announced the adoption of a new, ‘humane’ migration policy. The implementation of the reform, however, has been characterised by an apparent contradiction: while Morocco has leveraged the humanitarian and...
The circRNA-microRNA code
Circular RNAs (circRNAs) comprise an emerging new class of endogenous RNAs expressed abundantly by the eukaryotic transcriptome. They are characterized by a covalently closed loop structure, resulting in RNA molecules that are...
Superoxide Dismutase-3 Downregulates Laminin α5 Expression in Tumor Endothelial Cells via the Inhibition of Nuclear Factor Kappa B Signaling.
Lorena Carmona-Rodríguez, Diego Martínez-Rey, Paula Martín-González, Mónica Franch, Lydia Sorokin, Emilia Mira, Santos Mañes
Mar 02, 2022
The balance between laminin isoforms containing the α5 or the α4 chain in the endothelial basement membrane determines the site of leukocyte diapedesis under inflammatory conditions. Extracellular superoxide dismutase (SOD3)...
Evaluation of Methodologies for Assessing Self-Healing Performance of Concrete with Mineral Expansive Agents
Chrysoula Litina, Girts Bumanis, Giovanni Anglani, Marta Dudek, Riccardo Maddalena, Maria Amenta, Stamatoula Papaioannou, Gloria Pérez, José Luis García García Calvo, Eloy Asensio, Rubén Beltrán Cobos, Fabiano Tavares Pinto, Algirdas Augonis, Robert Davies, Ana Guerrero, Mercedes Sánchez Moreno, Teresa Stryszewska, Ioannis Karatasios, Jean-Marc Tulliani, Paola Antonaci, Diana Bajare, Abir Al-Tabbaa
Apr 18, 2021
Self-healing concrete has the potential to optimise traditional design approaches; however, commercial uptake requires the ability to harmonize against standardized frameworks. Within EU SARCOS COST Action, different...
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells
Vladimir Shapovalov, Liliya Kopanitsa, Lavinia-Lorena Pruteanu, Graham Ladds, David S. Bailey
Jul 28, 2021
We have used three established human glioblastoma (GBM) cell lines—U87MG, A172, and T98G—as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase...
Incorporation of bacteria in concrete
Strength improvement of cement-based materials by the addition of bacteria has been reported over the past decade and has been mainly attributed to microbially induced calcite precipitation (MICP 1). However, the...
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells.
Vladimir Shapovalov, Liliya Kopanitsa, Lavinia-Lorena Pruteanu, Graham Ladds, David S Bailey
Sep 08, 2021
We have used three established human glioblastoma (GBM) cell lines-U87MG, A172, and T98G-as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase...
Published by: Cancers
Robustness of radiomic features in CT images with different slice thickness, comparing liver tumour and muscle.
Lorena Escudero Sanchez, Leonardo Rundo, Andrew B Gill, Matthew Hoare, Eva Mendes Serrao, Evis Sala
Mar 31, 2021
Emotional valence modulates the topology of the parent-infant inter-brain network.
Lorena Santamaria, Valdas Noreika, Stanimira Georgieva, Kaili Clackson, Sam Wass, Victoria Leong
Nov 11, 2019
Parental neural responsivity to infants' visual attention
Sam V Wass, Valdas Noreika, Stanimira Georgieva, Kaili Clackson, Laura Brightman, Rebecca Nutbrown, Lorena Santamaria Covarrubias, Vicky Leong
Dec 21, 2018
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