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Applications of Sports Data to Study Decision Making
The features and determinants of human decision making, especially under competitive environments, have been a central theme of research in economics and psychology alike. This special issue centers on applying sports data to...
Applications of Sports Data to Study Decision Making
The features and determinants of human decision making, especially under competitive environments, have been a central theme of research in economics and psychology alike. This special issue centers on applying sports data to...
Suppression of inflammation by helminths
helminth-induced suppression of inflammation hookworms host–parasite interactions microbial richness Microbiota whipworms Ancylostomatoidea Animals Celiac disease Disease Models Animal Gastrointestinal Microbiome Helminths host-parasite interactions Humans Immunosuppression Therapy Inflammation Inflammatory Bowel Diseases Trichuris
Differential Protein Expression in the Hemolymph of $\textit{Bithynia siamensis goniomphalos}$ Infected with $\textit{Opisthorchis viverrini}$
K Suwannatrai, A Suwannatrai, P Tabsripair, JU Welbat, S Tangkawattana, C Cantacessi, J Mulvenna, S Tesana, A Loukas, J Sotillo
Dec 19, 2016
Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini.
Sattrachai Prasopdee, Smarn Tesana, Cinzia Cantacessi, Thewarach Laha, Jason Mulvenna, Rudi Grams, Alex Loukas, Javier Sotillo
Apr 13, 2015
Deep sequencing approach for investigating infectious agents causing fever.
TN Susilawati, AR Jex, C Cantacessi, M Pearson, S Navarro, A Susianto, AC Loukas, WJH McBride
Apr 22, 2016
Associations of genetically predicted fatty acid levels across the phenome
Loukas Zagkos, Marie-Joe Dib, Rui Pinto, Dipender Gill, Fotios Koskeridis, Fotios Drenos, Georgios Markozannes, Paul Elliott, Verena Zuber, Kostas Tsilidis, Abbas Dehghan, Ioanna Tzoulaki
Jan 28, 2023
BACKGROUND: Fatty acids are important dietary factors that have been extensively studied for their implication in health and disease. Evidence from epidemiological studies and randomised controlled trials on their role in...
Associations of genetically predicted fatty acid levels across the phenome
Loukas Zagkos, Marie-Joe Dib, Rui Pinto, Dipender Gill, Fotios Koskeridis, Fotios Drenos, Georgios Markozannes, Paul Elliott, Verena Zuber, Kostas Tsilidis, Abbas Dehghan, Ioanna Tzoulaki
Jan 04, 2023
BACKGROUND: Fatty acids are important dietary factors that have been extensively studied for their implication in health and disease. Evidence from epidemiological studies and randomised controlled trials on their role in...
Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects.
Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.
Leon Tribolet, Cinzia Cantacessi, Darren A Pickering, Severine Navarro, Denise L Doolan, Angela Trieu, Huang Fei, Yang Chao, Andreas Hofmann, Robin B Gasser, Paul R Giacomin, Alex Loukas
Aug 04, 2014
B cell CD79A Na-ASP-2 Necator americanus SCP/TAPS antigen receptor hookworm host–pathogen interaction protein microarray Adult Ancylostomatoidea Animals Antigens Helminth B-Lymphocytes CD79 Antigens Cells Cultured Down-Regulation Helminth Proteins Hookworm Infections Host-Pathogen Interactions Humans Leukocytes Mononuclear Middle Aged Phosphatidylinositol 3-Kinases Pre-B Cell Receptors Protein Array Analysis Proteome RNA Messenger Recombinant Proteins Signal Transduction Transcription Genetic Up-Regulation src-Family Kinases
Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype.
Sujittra Chaiyadet, Javier Sotillo, Michael Smout, Cinzia Cantacessi, Malcolm K Jones, Michael S Johnson, Lynne Turnbull, Cynthia B Whitchurch, Jeremy Potriquet, Marut Laohaviroj, Jason Mulvenna, Paul J Brindley, Jeffrey M Bethony, Thewarach Laha, Banchob Sripa, Alex Loukas
Jun 11, 2015
Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease
P Giacomin, M Zakrzewski, TP Jenkins, X Su, R Al-Hallaf, J Croese, S de Vries, A Grant, M Mitreva, A Loukas, L Krause, C Cantacessi
Jan 16, 2017
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
Chris Eijsbouts, Tenghao Zheng, Nicholas A Kennedy, Ferdinando Bonfiglio, Carl A Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, 23andMe Research Team, Alexandru-Ioan Voda, Bellygenes Initiative, Gianrico Farrugia, Andre Franke, Matthias Hübenthal, Gonçalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tõnu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J Whorwell, Robin Spiller, Gil McVean, Mauro D'Amato, Luke Jostins, Miles Parkes
Jan 05, 2022
Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK...
Aged Anxiety Disorders CD56 Antigen Cell Adhesion Molecules Cytoskeletal Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Homeodomain Proteins Humans Irritable Bowel Syndrome Male Middle Aged Molecular Chaperones Mood Disorders Polymorphism Single Nucleotide United Kingdom
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.
Aleksejs Sazonovs, Nicholas A Kennedy, Loukas Moutsianas, Graham A Heap, Daniel L Rice, Mark Reppell, Claire M Bewshea, Neil Chanchlani, Gareth J Walker, Mandy H Perry, Timothy J McDonald, Charlie W Lees, JR Fraser Cummings, Miles Parkes, John C Mansfield, Peter M Irving, Jeffrey C Barrett, Dermot McGovern, James R Goodhand, Carl A Anderson, Tariq Ahmad, PANTS Consortium
Nov 25, 2019
BACKGROUND & AIMS: Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The...
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M Croft, Carsten Posovszky, Astor Rodrigues, Richard K Russell, Farah Barakat, Marcus KH Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C Matte, Kimberly C Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A Baeumler, Tudor A Fulga, Eli M Carrami, Ahmed Ahmed, Rachel Wilson, Jeffrey C Barrett, Abdul Elkadri, Anne M Griffiths, COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Scott B Snapper, Neil Shah, Aleixo M Muise, David C Wilson, Holm H Uhlig, Carl A Anderson
Jan 31, 2020
Adult Age of Onset Case-Control Studies Child Child Preschool Cohort Studies Female Genes Recessive Genetic Predisposition to Disease genetic variation Humans Infant Infant Newborn Inflammatory Bowel Diseases Loss of Function Mutation Male Mosaicism Multifactorial Inheritance Mutation NADPH Oxidase 2 Pedigree Primary Immunodeficiency Diseases Risk Factors Exome Sequencing
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M Croft, Carsten Posovszky, Astor Rodrigues, Richard K Russell, Farah Barakat, Marcus K H Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C Matte, Kimberly C Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A Baeumler, Tudor A Fulga, Mohammad Karaminejadranjbar, Ahmed Ahmed, Rachel Wilson, Jeffrey C Barrett, Abdul Elkadri, Anne M Griffiths, Scott B Snapper, Neil Shah, Aleixo M Muise, David C Wilson, Holm H Uhlig, Carl A Anderson
Mar 25, 2020
Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients...
Published by: Nature Communications
Genetic mechanisms of critical illness in COVID-19.
Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D Bretherick, Konrad Rawlik, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alexandre C Pereira, Alessandra Renieri, GenOMICC Investigators, ISARIC4C investigators, COVID-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Xia Shen, Chris P Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter JM Openshaw, Malcolm G Semple, Andrew Law, Veronique Vitart, James F Wilson, J Kenneth Baillie
Dec 01, 2020
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets...
2' 5'-Oligoadenylate Synthetase covid-19 Chromosomes Human Pair 12 Chromosomes Human Pair 19 Chromosomes Human Pair 21 Critical Care Critical Illness Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Drug Repositioning Female Genome-Wide Association Study Humans Inflammation Lung Male Multigene Family Receptor Interferon alpha-beta Receptors CCR2 TYK2 Kinase United Kingdom
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey, Christopher A Odhams, Susan Walker, Clark D Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Sean Keating, Bo Wang, Daniel Rhodes, Lucija Klaric, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David Maslove, Alistair Nichol, Malcolm G Semple, Tala Zainy, Fiona Maleady-Crowe, Linda Todd, Shahla Salehi, Julian Knight, Greg Elgar, Georgia Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A Kosmicki, Julie E Horowitz, Aris Baras, Goncalo R Abecasis, Manuel AR Ferreira, Anne Justice, Tooraj Mirshahi, Matthew Oetjens, Daniel J Rader, Marylyn D Ritchie, Anurag Verma, Tom A Fowler, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter JM Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, GenOMICC Investigators, 23andMe Investigators, COVID-19 Human Genetics Initiative, Angie Fawkes, Lee Murphy, Kathy Rowan, Chris P Ponting, Veronique Vitart, James F Wilson, Jian Yang, Andrew D Bretherick, Richard H Scott, Sara Clohisey Hendry, Loukas Moutsianas, Andy Law, Mark J Caulfield, J Kenneth Baillie
Jul 07, 2022
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC...
ATP-Binding Cassette Transporters covid-19 Cell Adhesion Molecules Critical Care Critical Illness E-Selectin Factor VIII Fucosyltransferases Genome Human Genome-Wide Association Study Host-Pathogen Interactions Humans Interleukin-10 Receptor beta Subunit Lectins C-Type Mucin-1 Nerve Tissue Proteins Phospholipid Transfer Proteins Receptors Cell Surface Repressor Proteins SARS-CoV-2 whole genome sequencing
Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma
Christine L. Jones, Andrea Degasperi, Vieri Grandi, Tauanne D. Amarante, Tracey J. Mitchell, Serena Nik-Zainal, Sean J. Whittaker, John C. Ambrose, Prabhu Arumugam, Emma L. Baple, Marta Bleda, Freya Boardman-Pretty, Jeanne M. Boissiere, Christopher R. Boustred, Helen Brittain, Mark J. Caulfield, Georgia C. Chan, Clare E. H. Craig, Louise C. Daugherty, Anna de Burca, Andrew Devereau, Greg Elgar, Rebecca E. Foulger, Tom Fowler, Pedro Furió-Tarí, Adam Giess, Joanne M. Hackett, Dina Halai, Angela Hamblin, Shirley Henderson, James E. Holman, Tim J. P. Hubbard, Kristina Ibáñez, Rob Jackson, Louise J. Jones, Dalia Kasperaviciute, Melis Kayikci, Athanasios Kousathanas, Lea Lahnstein, Kay Lawson, Sarah E. A. Leigh, Ivonne U. S. Leong, Javier F. Lopez, Fiona Maleady-Crowe, Joanne Mason, Ellen M. McDonagh, Loukas Moutsianas, Michael Mueller, Nirupa Murugaesu, Anna C. Need, Peter O’Donovan, Chris A. Odhams, Andrea Orioli, Christine Patch, Mariana Buongermino Pereira, Daniel Perez-Gil, Dimitris Polychronopoulos, John Pullinger, Tahrima Rahim, Augusto Rendon, Pablo Riesgo-Ferreiro, Tim Rogers, Mina Ryten, Kevin Savage, Kushmita Sawant, Richard H. Scott, Afshan Siddiq, Alexander Sieghart, Damian Smedley, Katherine R. Smith, Samuel C. Smith, Alona Sosinsky, William Spooner, Helen E. Stevens, Alexander Stuckey, Razvan Sultana, Mélanie Tanguy, Ellen R. A. Thomas, Simon R. Thompson, Carolyn Tregidgo, Arianna Tucci, Emma Walsh, Sarah A. Watters, Matthew J. Welland, Eleanor Williams, Katarzyna Witkowska, Suzanne M. Wood, Magdalena Zarowiecki
Feb 17, 2021
Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders
Katherine R Schon, Rita Horvath, Wei Wei, Claudia Calabrese, Arianna Tucci, Kristina Ibañez, Thiloka Ratnaike, Robert D S Pitceathly, Enrico Bugiardini, Rosaline Quinlivan, Michael G Hanna, Emma Clement, Emma Ashton, John A Sayer, Paul Brennan, Dragana Josifova, Louise Izatt, Carl Fratter, Victoria Nesbitt, Timothy Barrett, Dominic J McMullen, Audrey Smith, Charulata Deshpande, Sarah F Smithson, Richard Festenstein, Natalie Canham, Mark Caulfield, Henry Houlden, Shamima Rahman(, Patrick F Chinnery, Genomics England Research Consortium, John C Ambrose, Prabhu Arumugam, Roel Bevers, Marta Bleda, Freya Boardman-Pretty, Christopher R Boustred, Helen Brittain, Mark J Caulfield, Georgia C Chan, Greg Elgar, Tom Fowler, Adam Giess, Angela Hamblin, Shirley Henderson, Tim J P Hubbard, Rob Jackson, Louise J Jones, Dalia Kasperaviciute, Melis Kayikci, Athanasios Kousathanas, Lea Lahnstein, Sarah E A Leigh, Ivonne U S Leong, Javier F Lopez, Fiona Maleady-Crowe, Meriel McEntegart, Federico Minneci, Loukas Moutsianas, Michael Mueller, Nirupa Murugaesu, Anna C Need, Peter O’Donovan, Chris A Odhams, Christine Patch, Mariana Buonerimo Pereira, Daniel Perez-Gil, John Pullinger, Tahrima Rahim, Augusto Rendon, Tim Rogers, Kevin Savage, Kushmita Sawant, Richard H Scott, Afshan Siddiq, Alexander Sieghart, Samuel C Smith, Alona Sosinsky, Alexander Stuckey, Mélanie Tanguy, Ana Lisa Taylor Tavares, Ellen R A Thomas, Simon R Thompson, Matthew J Welland, Eleanor Williams, Katarzyna Witkowska, Suzanne M Wood
Nov 05, 2021
Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders
Katherine R Schon, Rita Horvath, Wei Wei, Claudia Calabrese, Arianna Tucci, Kristina Ibañez, Thiloka Ratnaike, Robert D S Pitceathly, Enrico Bugiardini, Rosaline Quinlivan, Michael G Hanna, Emma Clement, Emma Ashton, John A Sayer, Paul Brennan, Dragana Josifova, Louise Izatt, Carl Fratter, Victoria Nesbitt, Timothy Barrett, Dominic J McMullen, Audrey Smith, Charulata Deshpande, Sarah F Smithson, Richard Festenstein, Natalie Canham, Mark Caulfield, Henry Houlden, Shamima Rahman(, Patrick F Chinnery, Genomics England Research Consortium, John C Ambrose, Prabhu Arumugam, Roel Bevers, Marta Bleda, Freya Boardman-Pretty, Christopher R Boustred, Helen Brittain, Mark J Caulfield, Georgia C Chan, Greg Elgar, Tom Fowler, Adam Giess, Angela Hamblin, Shirley Henderson, Tim J P Hubbard, Rob Jackson, Louise J Jones, Dalia Kasperaviciute, Melis Kayikci, Athanasios Kousathanas, Lea Lahnstein, Sarah E A Leigh, Ivonne U S Leong, Javier F Lopez, Fiona Maleady-Crowe, Meriel McEntegart, Federico Minneci, Loukas Moutsianas, Michael Mueller, Nirupa Murugaesu, Anna C Need, Peter O’Donovan, Chris A Odhams, Christine Patch, Mariana Buonerimo Pereira, Daniel Perez-Gil, John Pullinger, Tahrima Rahim, Augusto Rendon, Tim Rogers, Kevin Savage, Kushmita Sawant, Richard H Scott, Afshan Siddiq, Alexander Sieghart, Samuel C Smith, Alona Sosinsky, Alexander Stuckey, Mélanie Tanguy, Ana Lisa Taylor Tavares, Ellen R A Thomas, Simon R Thompson, Matthew J Welland, Eleanor Williams, Katarzyna Witkowska, Suzanne M Wood
Nov 04, 2021
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Chris Eijsbouts, Tenghao Zheng, Nicholas A. Kennedy, Ferdinando Bonfiglio, Carl A. Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, Alexandru-Ioan Voda, Gianrico Farrugia, Andre Franke, Matthias Hübenthal, Gonçalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tõnu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J. Whorwell, Robin Spiller, Gil McVean, Mauro D’Amato, Luke Jostins, Miles Parkes, Michelle Agee, Stella Aslibekyan, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah K. Clark, Sarah L. Elson, Kipper Fletez-Brant, Pierre Fontanillas, Nicholas A. Furlotte, Pooja M. Gandhi, Karl Heilbron, Barry Hicks, David A. Hinds, Karen E. Huber, Ethan M. Jewett, Yunxuan Jiang, Aaron Kleinman, Keng-Han Lin, Nadia K. Litterman, Marie K. Luff, Jey C. McCreight, Matthew H. McIntyre, Kimberly F. McManus, Joanna L. Mountain, Sahar V. Mozaffari, Priyanka Nandakumar, Elizabeth S. Noblin, Carrie A. M. Northover, Jared O’Connell, Aaron A. Petrakovitz, Steven J. Pitts, G. David Poznik, J. Fah Sathirapongsasuti, Anjali J. Shastri, Janie F. Shelton, Chao Tian, Joyce Y. Tung, Robert J. Tunney, Vladimir Vacic, Xin Wang, Amir S. Zare, Purna Kashyap, Lin Chang, Emeran Mayer, Margaret Heitkemper, Gregory S. Sayuk, Tamar Ringel-Kulka, Yehuda Ringel, William D. Chey, Shanti Eswaran, Juanita L. Merchant, Robert J. Shulman, Luis Bujanda, Koldo Garcia-Etxebarria, Aldona Dlugosz, Greger Lindberg, Peter T. Schmidt, Pontus Karling, Bodil Ohlsson, Susanna Walter, Åshild O. Faresjö, Magnus Simren, Jonas Halfvarson, Piero Portincasa, Giovanni Barbara, Paolo Usai-Satta, Matteo Neri, Gerardo Nardone, Rosario Cuomo, Francesca Galeazzi, Massimo Bellini, Anna Latiano, Lesley Houghton, Daisy Jonkers, Alexander Kurilshikov, Rinse K. Weersma, Mihai Netea, Jonas Tesarz, Annika Gauss, Miriam Goebel-Stengel, Viola Andresen, Thomas Frieling, Christian Pehl, Rainer Schaefert, Beate Niesler, Wolfgang Lieb, Kurt Hanevik, Nina Langeland, Knut-Arne Wensaas, Sverre Litleskare, Maiken E. Gabrielsen, Laurent Thomas, Vincent Thijs, Robin Lemmens, Lukas Van Oudenhove, Mira Wouters
Nov 06, 2021
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Chris Eijsbouts, Tenghao Zheng, Nicholas A. Kennedy, Ferdinando Bonfiglio, Carl A. Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, Alexandru-Ioan Voda, Gianrico Farrugia, Andre Franke, Matthias Hübenthal, Gonçalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tõnu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J. Whorwell, Robin Spiller, Gil McVean, Mauro D’Amato, Luke Jostins, Miles Parkes, Michelle Agee, Stella Aslibekyan, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah K. Clark, Sarah L. Elson, Kipper Fletez-Brant, Pierre Fontanillas, Nicholas A. Furlotte, Pooja M. Gandhi, Karl Heilbron, Barry Hicks, David A. Hinds, Karen E. Huber, Ethan M. Jewett, Yunxuan Jiang, Aaron Kleinman, Keng-Han Lin, Nadia K. Litterman, Marie K. Luff, Jey C. McCreight, Matthew H. McIntyre, Kimberly F. McManus, Joanna L. Mountain, Sahar V. Mozaffari, Priyanka Nandakumar, Elizabeth S. Noblin, Carrie A. M. Northover, Jared O’Connell, Aaron A. Petrakovitz, Steven J. Pitts, G. David Poznik, J. Fah Sathirapongsasuti, Anjali J. Shastri, Janie F. Shelton, Chao Tian, Joyce Y. Tung, Robert J. Tunney, Vladimir Vacic, Xin Wang, Amir S. Zare, Purna Kashyap, Lin Chang, Emeran Mayer, Margaret Heitkemper, Gregory S. Sayuk, Tamar Ringel-Kulka, Yehuda Ringel, William D. Chey, Shanti Eswaran, Juanita L. Merchant, Robert J. Shulman, Luis Bujanda, Koldo Garcia-Etxebarria, Aldona Dlugosz, Greger Lindberg, Peter T. Schmidt, Pontus Karling, Bodil Ohlsson, Susanna Walter, Åshild O. Faresjö, Magnus Simren, Jonas Halfvarson, Piero Portincasa, Giovanni Barbara, Paolo Usai-Satta, Matteo Neri, Gerardo Nardone, Rosario Cuomo, Francesca Galeazzi, Massimo Bellini, Anna Latiano, Lesley Houghton, Daisy Jonkers, Alexander Kurilshikov, Rinse K. Weersma, Mihai Netea, Jonas Tesarz, Annika Gauss, Miriam Goebel-Stengel, Viola Andresen, Thomas Frieling, Christian Pehl, Rainer Schaefert, Beate Niesler, Wolfgang Lieb, Kurt Hanevik, Nina Langeland, Knut-Arne Wensaas, Sverre Litleskare, Maiken E. Gabrielsen, Laurent Thomas, Vincent Thijs, Robin Lemmens, Lukas Van Oudenhove, Mira Wouters
Nov 22, 2021
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Mohammad Karaminejadranjbar, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson, Marlen Zurek, Caterina Strisciuglio, Mamoun Elawad, Bernice Lo, Carolina Arancibia-Carcamo, Adam Bailey, Ellie Barnes, Elizabeth Louise Bird-Lieberman, Oliver Brain, Barbara Braden, Jane Collier, James East, Lucy Howarth, Satish Keshav, Paul Klenerman, Simon Leedham, Rebecca Palmer, Fiona Powrie, Alison Simmons, Matthew Walker, Zoe Tolkien, Stephen Kaptoge, David Allen, Susan Mehenny, Jonathan Mant, Emanuele Di Angelantonio, Simon G. Thompson, Bahtiyar Yilmaz, Pascal Juillerat, Markus Geuking, Reiner Wiest, Andrew J. Macpherson, Francisco Damian Bravo, Lukas Brügger, Ove Carstens, Ulrike Graf Bigler, Benjamin Heimgartner, Monica Rusticeanu, Sybille Schmid (-Uebelhart), Bruno Strebel, Aurora Tatu, Radu Tutuian, Ove Øyås, Charlotte Ramon, Jörg Stelling, Yannick Franc, Nicolas Fournier, Valerie E. H. Pittet, Bernard Burnand, Mara Egger, Delphine Golay, Astrid Marot, Leilla Musso, Valérie Pittet, Jean-Benoît Rossel, Vivianne Seematter, Joachim Sommer, Rachel Vulliamy, Pierre Michetti, Michel H. Maillard, Céline Keller, Andreas Nydegger, Alain Schoepfe, Eva Archanioti, Jessica Ezri, Montserrat Fraga, Alain Schoepfer, Christoph Müller, Gerhard Rogler, Luc Biedermann, Mirjam Blattmann, Sabine Burk, Barbara Dora, Michael Fried, Benjamin Misselwitz, Beat Müllhaupt, Nicole Obialo, Daniel Pohl, Nadia Raschle, Michael Scharl, Stephan Vavricka, Roland Von Känel, Jonas Zeitz, Karim Abdelrahman, Gentiana Ademi, Jan Borovicka, Stephan Brand, Remus Frei, Johannes Haarer, Christina Knellwolf (-Grieger), Claudia Krieger(-Grübel), Patrizia Künzler, Christa Meyenberger, Pamela Meyer, Nina Röhrich, Mikael Sawatzki, Martin Schelling, Gian-Marco Semadeni, Michael Sulz, Dorothee Zimmermann, Patrick Aepli, Dominique H. Criblez, Cyrill Hess, Jean-Pierre Richterich, Johannes Spalinger, Dominic Staudenmann, Andreas Stulz, Stefanie Wöhrle, Amman Thomas, Claudia Anderegg, Henrik Köhler, Rachel Kusche, Anca-Teodora Antonino, Eviano Arrigoni, José M. Bengoa, Sophie Cunningham, Philippe de Saussure, Laurent Girard, Diana Bakker de Jong, Polat Bastürk, Simon Brunner, Lukas Degen, Petr Hruz, Carolina Khalid-de Bakker, Jan Niess, Bruno Balsiger, Janine Haldemann, Gaby Saner, Frank Seibold, Peter Bauerfeind, Andrea Becocci, Dominique Belli, Janek Binek, Peter Hengstler, Stephan Boehm, Tujana Boldanov, Patrick Bühr, Rebekka Koller, Vanessa Rueger, Arne Senning, Emanuel Burri, Sophie Buyse, Dahlia-Thao Cao, Fabrizia D’Angelo, Joakim Delarive, Christopher Doerig, Roxane Hessler, Claudia Preissler, Ronald Rentsch, Branislav Risti, Marc Alain Ritz, Michael Steuerwald, Jürg Vögtlin, Markus Sagmeister, Bernhard Sauter, Susanne Schibli, Christiane Sokollik, Hugo Schlauri, Jean-François Schnegg, Mariam Seirafi, Holger Spangenberger, Philippe Stadler, Peter Staub, Volker Stenz, Michela Tempia-Caliera, Joël Thorens, Kaspar Truninger, Patrick Urfer, Francesco Viani, Dominique Vouillamoz, Silvan Zander, Tina Wyli, L. Jostins, N. A. Kennedy, T. Ahmad, C. A. Lamb, C. Edwards, A. Hart, C. Hawkey, J. C. Mansfield, C. Mowat, W. G. Newman, A. Simmons, M. Tremelling, J. C. Lee, N. J. Prescott, C. G. Mathew, C. W. Lees, D. P. B. McGovern, S. R. Targan, G. Botwin, E. Mengesha, P. Fleshner, C. Landers, D. Li, J. D. Rioux, A. Bitton, J. Côté-Daigneault, M. J. Daly, R. Xavier, K. Morris, G. Boucher, J. H. Cho, C. Abraham, M. Merad, B. Sands, I. Peter, K. Hao, Y. Itan, R. H. Duerr, L. Konnikova, M. B. Schwartz, S. Proksell, E. Johnston, V. Miladinova, W. Chen, S. R. Brant, L. Datta, M. S. Silverberg, L. P. Schumm, S. Birch, M. Giri, K. Gettler, Y. Sharma, C. Stevens, M. Lazarev, T. Haritunians
Feb 20, 2021
Abstract: Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145...
The genetic architecture of type 2 diabetes.
Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John RB Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen CJ Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie CY Ng, Nicholette D Palmer, Beverley Balkau, Alena Stančáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna MM Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent KL Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia HT Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex SF Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, AnneMari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin NA Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana CN Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald CW Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth JF Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Noël P Burtt, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C Florez, Laura J Scott, Andrew P Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I McCarthy
Nov 20, 2017
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores...
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