The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably...
Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or BRCA2 mutations, has been used for developing new therapies in certain types of breast, ovarian and...
Whole genome sequencing of human tumours has revealed distinct patterns of mutation that hint at the causative origins of cancer. Experimental investigations of the mutations and mutation spectra induced by environmental...
Germline mutations are a driving force behind genome evolution and genetic disease. We investigated genome-wide mutation rates and spectra in multi-sibling families. The mutation rate increased with paternal age in all families...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of...
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
A measurement of four branching-fraction ratios for three-body decays of $B$
mesons involving two open-charm hadrons in the final state is presented. Run 1
and Run 2 $pp$ collision data are used, recorded by the LHCb experiment...
Abstract: Measurements of CP observables in B± → D(*)K± and B± → D(*)π± decays are presented, where D(∗) indicates a neutral D or D∗ meson that is an admixture of meson and anti-meson states. Decays of the D(∗) meson to the Dπ0...
Abstract: Measurements of CP observables in B± → D(*)K± and B± → D(*)π± decays are presented, where D(∗) indicates a neutral D or D∗ meson that is an admixture of meson and anti-meson states. Decays of the D(∗) meson to the Dπ0...
Abstract: We report on the calculation of the next-to-leading order QCD corrections to the production of a tt¯ pair in association with two heavy-flavour jets. We concentrate on the di-lepton tt¯ decay channel at the LHC with s...
Abstract: A search is presented for the lepton flavour violating decay B+ → K+μ−τ+ using a sample of proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to...
Abstract: Measurements of CP observables in B± → DK± and B± → Dπ± decays are presented, where D represents a superposition of D0 and D¯0 states. The D meson is reconstructed in the three-body final states KS0K±π∓ and KS0K∓π±....
Abstract: A search is presented for the lepton flavour violating decay B+ → K+μ−τ+ using a sample of proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to...
Phosphoinositide-3 kinase (PI3K) signaling is important for the survival of numerous cell types and class IA of PI3K is specifically required for the development of B cells but not for T cell development. Here, we show that...
Abstract: A measurement of CP-violating observables is performed using the decays B± → DK± and B± → Dπ±, where the D meson is reconstructed in one of the self-conjugate three-body final states KS0π+π− and KS0K+K− (commonly...
Abstract: A structure is observed in the B±K∓ mass spectrum in a sample of proton–proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to a total integrated...
Abstract: Measurements of CP observables in B± → DK± and B± → Dπ± decays are presented, where D represents a superposition of D0 and D¯0 states. The D meson is reconstructed in the three-body final states KS0K±π∓ and KS0K∓π±....
Abstract: A measurement of CP-violating observables is performed using the decays B± → DK± and B± → Dπ±, where the D meson is reconstructed in one of the self-conjugate three-body final states KS0π+π− and KS0K+K− (commonly...
BACKGROUND: Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV might accelerate hepatocyte ageing and investigated the...