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Emerging from the Mist
Ludovic Highman
Jan 11, 2021
The French higher education landscape has been considerably altered in the early twenty-first century. In order to enhance the competitiveness of the sector at the global level, the French government has steered the system...
Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.
Toni I Gossmann, Achchuthan Shanmugasundram, Stefan Börno, Ludovic Duvaux, Christophe Lemaire, Heiner Kuhl, Sven Klages, Lee D Roberts, Sophia Schade, Johanna M Gostner, Falk Hildebrand, Jakob Vowinckel, Coraline Bichet, Michael Mülleder, Enrica Calvani, Aleksej Zelezniak, Julian L Griffin, Peer Bork, Dominique Allaine, Aurélie Cohas, John J Welch, Bernd Timmermann, Markus Ralser
Apr 16, 2019
Emerging from the Mist
Ludovic Highman
Jan 11, 2021
The French higher education landscape has been considerably altered in the early twenty-first century. In order to enhance the competitiveness of the sector at the global level, the French government has steered the system...
Derivation of Multipotent Neural Progenitors from Human Embryonic Stem Cells for Cell Therapy and Biomedical Applications.
Long-term neuroepithelial-like stem cells (lt-NES) derived from human embryonic stem cells are a stable self-renewing progenitor population with high neurogenic potential and phenotypic plasticity. Lt-NES are amenable to...
Evidence for a disordered critical point in a glass-forming liquid
Using computer simulations of an atomistic glass-forming liquid, we investigate the fluctuations of the overlap between a fluid configuration and a quenched reference system. We find that large fluctuations of the overlap...
Variability of human pluripotent stem cell lines.
Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely...
Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D.
Evidence for a disordered critical point in a glass-forming liquid
Using computer simulations of an atomistic glass-forming liquid, we investigate the fluctuations of the overlap between a fluid configuration and a quenched reference system. We find that large fluctuations of the overlap...
Monogenic Diabetes Modeling
The occurrence of diabetes mellitus is characterized by pancreatic β cell loss and chronic hyperglycemia. While Type 1 and Type 2 diabetes are the most common types, rarer forms involve mutations affecting a single gene. This...
Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm
Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W. chondrophila...
Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm.
Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W. chondrophila...
Nature of excitations and defects in structural glasses.
The nature of defects in amorphous materials, analogous to vacancies and dislocations in crystals, remains elusive. Here, we explore their nature in a three-dimensional microscopic model glass-former that describes granular...
Genomic control of metastasis.
Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic level has...
Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications.
The liver, lung, pancreas, and digestive tract all originate from the endoderm germ layer, and these vital organs are subject to many life-threatening diseases affecting millions of patients. However, primary cells from...
Genomic control of metastasis
Abstract: Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic...
3-D reconstruction of sub-wavelength scatterers from the measurement of scattered fields in elastic waveguides
In nondestructive testing, being able to remotely locate and size defects with good accuracy is an important requirement in many industrial sectors, such as the petrochemical, nuclear, and aerospace industries. The potential...
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