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Genomic control of metastasis
Abstract: Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic...
Genomic control of metastasis.
Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic level has...
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Saroor A Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K Richardson, Jianfeng Ge, Saiful E Syafruddin, Alyson Speed, Evangelia K Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J Harrison, Grant D Stewart, Mitchell J Machiela, Mark P Purdue, Stephen J Chanock, Anne Y Warren, Shamith A Samarajiwa, Jason S Carroll, Sakari Vanharanta
Jul 09, 2022
Emerging from the Mist
Ludovic Highman
Jan 11, 2021
The French higher education landscape has been considerably altered in the early twenty-first century. In order to enhance the competitiveness of the sector at the global level, the French government has steered the system...
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Saroor A Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K Richardson, Jianfeng Ge, Saiful E Syafruddin, Alyson Speed, Eva Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J Harrison, Grant Stewart, Mitchell J Machiela, Mark P Purdue, Stephen J Chanock, Anne Warren, Shamith A Samarajiwa, Jason Carroll, Sakari Vanharanta
Jun 30, 2022
Emerging from the Mist
Ludovic Highman
Jan 11, 2021
The French higher education landscape has been considerably altered in the early twenty-first century. In order to enhance the competitiveness of the sector at the global level, the French government has steered the system...
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Saroor A Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K Richardson, Jianfeng Ge, Saiful E Syafruddin, Alyson Speed, Eva Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J Harrison, Grant Stewart, Mitchell J Machiela, Mark P Purdue, Stephen J Chanock, Anne Warren, Shamith A Samarajiwa, Jason Carroll, Sakari Vanharanta
Jun 29, 2022
Derivation of Multipotent Neural Progenitors from Human Embryonic Stem Cells for Cell Therapy and Biomedical Applications.
Long-term neuroepithelial-like stem cells (lt-NES) derived from human embryonic stem cells are a stable self-renewing progenitor population with high neurogenic potential and phenotypic plasticity. Lt-NES are amenable to...
Evidence for a disordered critical point in a glass-forming liquid
Using computer simulations of an atomistic glass-forming liquid, we investigate the fluctuations of the overlap between a fluid configuration and a quenched reference system. We find that large fluctuations of the overlap...
Variability of human pluripotent stem cell lines.
Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely...
Evidence for a disordered critical point in a glass-forming liquid
Using computer simulations of an atomistic glass-forming liquid, we investigate the fluctuations of the overlap between a fluid configuration and a quenched reference system. We find that large fluctuations of the overlap...
Monogenic Diabetes Modeling
The occurrence of diabetes mellitus is characterized by pancreatic β cell loss and chronic hyperglycemia. While Type 1 and Type 2 diabetes are the most common types, rarer forms involve mutations affecting a single gene. This...
Nature of excitations and defects in structural glasses.
The nature of defects in amorphous materials, analogous to vacancies and dislocations in crystals, remains elusive. Here, we explore their nature in a three-dimensional microscopic model glass-former that describes granular...
Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm
Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W. chondrophila...
Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm.
Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W. chondrophila...
Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications.
The liver, lung, pancreas, and digestive tract all originate from the endoderm germ layer, and these vital organs are subject to many life-threatening diseases affecting millions of patients. However, primary cells from...
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