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Results: 27
Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease.
Campbell Le Heron, Sanjay Manohar, Olivia Plant, Kinan Muhammed, Ludovica Griffanti, Andrea Nemeth, Gwenaëlle Douaud, Hugh S Markus, Masud Husain
Dec 11, 2018
Apathy is a syndrome of reduced motivation that commonly occurs in patients with cerebral small vessel disease, including those with the early onset form, CADASIL (cerebral autosomal dominant arteriopathy with subcortical...
Automated Detection of Candidate Subjects With Cerebral Microbleeds Using Machine Learning.
Vaanathi Sundaresan, Christoph Arthofer, Giovanna Zamboni, Robert A Dineen, Peter M Rothwell, Stamatios N Sotiropoulos, Dorothee P Auer, Daniel J Tozer, Hugh S Markus, Karla L Miller, Iulius Dragonu, Nikola Sprigg, Fidel Alfaro-Almagro, Mark Jenkinson, Ludovica Griffanti
Mar 12, 2022
Cerebral microbleeds (CMBs) appear as small, circular, well defined hypointense lesions of a few mm in size on T2*-weighted gradient recalled echo (T2*-GRE) images and appear enhanced on susceptibility weighted images (SWI). Due...
Automated Detection of Candidate Subjects With Cerebral Microbleeds Using Machine Learning.
Vaanathi Sundaresan, Christoph Arthofer, Giovanna Zamboni, Robert A Dineen, Peter M Rothwell, Stamatios N Sotiropoulos, Dorothee P Auer, Daniel J Tozer, Hugh Markus, Karla L Miller, Iulius Dragonu, Nikola Sprigg, Fidel Alfaro-Almagro, Mark Jenkinson, Ludovica Griffanti
Feb 03, 2022
Cerebral microbleeds (CMBs) appear as small, circular, well defined hypointense lesions of a few mm in size on T2*-weighted gradient recalled echo (T2*-GRE) images and appear enhanced on susceptibility weighted images (SWI). Due...
Molecular Landscape of Acute Myeloid Leukemia
PURPOSE OF REVIEW: The field of acute myeloid leukemia (AML) has been revolutionized in recent years by the advent of high-throughput techniques, such as next-generation sequencing. In this review, we will discuss some of the...
Why do users trust algorithms? A review and conceptualization of initial trust and trust over time
Algorithms are increasingly playing a pivotal role in organizations' day-to-day operations; however, a general distrust of artificial intelligence-based algorithms and automated processes persists. This aversion to algorithms...
Why do users trust algorithms? A review and conceptualization of initial trust and trust over time
Algorithms are increasingly playing a pivotal role in organizations' day-to-day operations; however, a general distrust of artificial intelligence-based algorithms and automated processes persists. This aversion to algorithms...
Engaging the Crowd
In this article, the challenges of realising e-participatory projects in urban planning are described. A participatory case study in Singapore serves as the basis for their presented conclusions. The researchers used a map-based...
Published by: IGI Global Scientific Publishing
Hematopoietic stem cells made BETter by inhibition.
Bromodomain and extra terminal (BET) proteins comprise the ubiquitously expressed BRD2, BRD3, BRD4 and the testes specific BRDT. These multipurpose proteins contain tandem N-terminal bromodomains that bind acetylated lysine...
Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection
Eugene Duff, Fernando Zelaya, Fidel Alfaro Almagro, Karla L Miller, Naomi Martin, Thomas E Nichols, Bernd Taschler, Ludovica Griffanti, Christoph Arthofer, Gwenaëlle Douaud, Chaoyue Wang, Thomas W Okell, Richard AI Bethlehem, Klaus Eickel, Matthias Günther, David K Menon, Guy Williams, Bethany Facer, David J Lythgoe, Flavio Dell'Acqua, Greta K Wood, Steven Cr Williams, Gavin Houston, Simon S Keller, Catherine Holden, Monika Hartmann, Lily George, Gerome Breen, Benedict D Michael, Peter Jezzard, Stephen M Smith, Edward T Bullmore, COVID-CNS Consortium
Sep 29, 2022
The Resilient Organisation
The Input-Process-Output framework is adopted to examine the impact of diversity attributes (the input) on communication (the process) and their influence on performance (the output), to understand the internal group/team...
The Resilient Organisation
The Input-Process-Output framework is adopted to examine the impact of diversity attributes (the input) on communication (the process) and their influence on performance (the output), to understand the internal group/team...
Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection
Eugene Duff, Fernando Zelaya, Fidel Alfaro Almagro, Karla L Miller, Naomi Martin, Thomas E Nichols, Bernd Taschler, Ludovica Griffanti, Christoph Arthofer, Gwenaëlle Douaud, Chaoyue Wang, Thomas W Okell, Richard AI Bethlehem, Klaus Eickel, Matthias Günther, David K Menon, Guy Williams, Bethany Facer, David J Lythgoe, Flavio Dell'Acqua, Greta K Wood, Steven Cr Williams, Gavin Houston, Simon S Keller, Catherine Holden, Monika Hartmann, Lily George, Gerome Breen, Benedict D Michael, Peter Jezzard, Stephen M Smith, Edward T Bullmore, COVID-CNS Consortium
Oct 30, 2022
Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
Camille Martin-Gallausiaux, Pierre Larraufie, Anne Jarry, Fabienne Béguet-Crespel, Ludovica Marinelli, Florence Ledue, Frank Reimann, Hervé M Blottière, Nicolas Lapaque
Dec 20, 2018
Commensal bacteria are crucial for the development and maintenance of a healthy immune system therefore contributing to the global well-being of their host. A wide variety of metabolites produced by commensal bacteria are...
IDO-1 butyrate Gut microbiota immune gene regulation intestinal epithelial cells Bacteria Butyric Acid Caco-2 Cells Down-Regulation Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Regulation Developmental Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Interferon-gamma Intestinal Mucosa Male Middle Aged Receptors G-Protein-Coupled Transcription Factors
A systematic review on the impact of commercially available hybrid closed loop systems on psychological outcomes in youths with type 1 diabetes and their parents
Roberto Franceschi, Enza Mozzillo, Francesca Di Candia, Evelina Maines, Letizia Leonardi, Martina Girardi, Ludovica Fedi, Francesco Maria Rosanio, M. Loredana Marcovecchio
Apr 17, 2023
Aim: To systematically assess the impact of commercially available hybrid closed loop (HCL) systems on psychological outcomes in youths with type 1 diabetes and their parents. Methods: We performed a systematic review including...
The Genetic Origin of Daunians and the Pan-Mediterranean Southern Italian Iron Age Context.
Serena Aneli, Tina Saupe, Francesco Montinaro, Anu Solnik, Ludovica Molinaro, Cinzia Scaggion, Nicola Carrara, Alessandro Raveane, Toomas Kivisild, Mait Metspalu, Christiana L Scheib, Luca Pagani
Feb 17, 2022
The geographical location and shape of Apulia, a narrow land stretching out in the sea at the South of Italy, made this region a Mediterranean crossroads connecting Western Europe and the Balkans. Such movements culminated at...
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana SH Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao ML Dias, Haiyang Yun, Daniel Sasca, Sarah J Horton, George Vassiliou, Christian Frezza, Brian JP Huntly
May 08, 2018
Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.
Mathew Van de Pette, Allifia Abbas, Amelie Feytout, Gráinne McNamara, Ludovica Bruno, Wilson K To, Andrew Dimond, Alessandro Sardini, Zoe Webster, James McGinty, Eleanor J Paul, Mark A Ungless, Paul MW French, Dominic J Withers, Anthony Uren, Anne C Ferguson-Smith, Matthias Merkenschlager, Rosalind M John, Amanda G Fisher
Mar 11, 2020
Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor...
miR-181a/b downregulation exerts a protective action on mitochondrial disease models.
Alessia Indrieri, Sabrina Carrella, Alessia Romano, Alessandra Spaziano, Elena Marrocco, Erika Fernandez-Vizarra, Sara Barbato, Mariateresa Pizzo, Yulia Ezhova, Francesca M Golia, Ludovica Ciampi, Roberta Tammaro, Jorge Henao-Mejia, Adam Williams, Richard A Flavell, Elvira De Leonibus, Massimo Zeviani, Enrico M Surace, Sandro Banfi, Brunella Franco
Sep 13, 2019
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.
John B Sanderson, Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini, Aurelia Hays Watson, Laura De Boni, Valentina N Lagomarsino, Tracy L Young-Pearse, Xinyue Liu, Thomas C Pochapsky, Bradley T Hyman, Dennis W Dickson, David Klenerman, Dennis J Selkoe, Tim Bartels
May 13, 2020
Since researchers identified α-synuclein as the principal component of Lewy bodies and Lewy neurites, studies have suggested that it plays a causative role in the pathogenesis of dementia with Lewy bodies and other...
Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice.
Mathew Van de Pette, Andrew Dimond, António M Galvão, Steven J Millership, Wilson To, Chiara Prodani, Gráinne McNamara, Ludovica Bruno, Alessandro Sardini, Zoe Webster, James McGinty, Paul MW French, Anthony G Uren, Juan Castillo-Fernandez, William Watkinson, Anne C Ferguson-Smith, Matthias Merkenschlager, Rosalind M John, Gavin Kelsey, Amanda G Fisher
Jun 07, 2022
Transmission of epigenetic information between generations occurs in nematodes, flies and plants, mediated by specialised small RNA pathways, modified histones and DNA methylation. Similar processes in mammals can also affect...
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.
Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci, Lucia Di Marcotullio
Jul 23, 2020
The Hedgehog (Hh) pathway is essential for embryonic development and tissue homeostasis. Aberrant Hh signaling may occur in a wide range of human cancers, such as medulloblastoma, the most common brain malignancy in childhood....
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy.
Dorian Forte, María García-Fernández, Abel Sánchez-Aguilera, Vaia Stavropoulou, Claire Fielding, Daniel Martín-Pérez, Juan Antonio López, Ana SH Costa, Laura Tronci, Efterpi Nikitopoulou, Michael Barber, Paolo Gallipoli, Ludovica Marando, Carlos López Fernández de Castillejo, Alexandar Tzankov, Sabine Dietmann, Michele Cavo, Lucia Catani, Antonio Curti, Jesús Vázquez, Christian Frezza, Brian J Huntly, Juerg Schwaller, Simón Méndez-Ferrer
Sep 03, 2020
OXPHOS TCA cycle acute myeloid leukemia antioxidant bone marrow mesenchymal stem cells Chemotherapy Glutathione hematopoietic stem cell niche metabolic adaptation microenvironment Animals Antineoplastic Agents antioxidants Bone Marrow Cells Cultured Energy Metabolism Female Humans Leukemia Myeloid Acute Male Mesenchymal Stem Cells Mice Mice Inbred C57BL Middle Aged
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Pedro Madrigal, Daniel Sasca, David Lara-Astiaso, Sarah J Horton, Shuchi Agrawal-Singh, Eshwar Meduri, Faisal Basheer, Ludovica Marando, Malgorzata Gozdecka, Oliver M Dovey, Aracely Castillo-Venzor, Xiaonan Wang, Paolo Gallipoli, Carsten Müller-Tidow, Cameron S Osborne, George S Vassiliou, Brian JP Huntly
Aug 12, 2021
Animals Base Sequence Chromatin Assembly and Disassembly DNA Neoplasm Disease Models Animal Enhancer Elements Genetic Gene Expression Regulation Leukemic Gene Regulatory Networks Genetic Loci Histones Humans Leukemia Myeloid Acute Mice Inbred C57BL Mutation Nuclear Proteins Nucleophosmin principal component analysis Protein Processing Post-Translational RNA Messenger Transcription Genetic fms-Like Tyrosine Kinase 3
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