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Comparison of drug release from poly(lactide-co-glycolide) microspheres and novel fibre formulations
Intraperitoneal cisplatin delivery has recently been shown to benefit ovarian cancer patients. Cisplatin-containing poly(lactide-co-glycolide) (PLGA) microspheres have been proposed for cisplatin delivery. The drug loading of...
Effective use of transdermal drug delivery in children
Transdermal administration offers a non-invasive and convenient method for paediatric drug delivery. The competent skin barrier function in term infants and older children limits both water loss and the percutaneous entry of...
Effective use of transdermal drug delivery in children
Transdermal administration offers a non-invasive and convenient method for paediatric drug delivery. The competent skin barrier function in term infants and older children limits both water loss and the percutaneous entry of...
Transdermal iontophoresis of ranitidine
The objective of this study was to examine the use of transdermal iontophoresis for the delivery of ranitidine hydrochloride in children. Constant, direct current, anodal iontophoresis of ranitidine was performed in vitro across...
Transdermal iontophoresis of ranitidine
The objective of this study was to examine the use of transdermal iontophoresis for the delivery of ranitidine hydrochloride in children. Constant, direct current, anodal iontophoresis of ranitidine was performed in vitro across...
Comparison of drug release from poly(lactide-co-glycolide) microspheres and novel fibre formulations
Intraperitoneal cisplatin delivery has recently been shown to benefit ovarian cancer patients. Cisplatin-containing poly(lactide-co-glycolide) (PLGA) microspheres have been proposed for cisplatin delivery. The drug loading of...
Evaluation of an explanted porcine skin model to investigate infection with the dermatophyte Trichophyton rubrum.
Dermatophytosis is a fungal infection of skin, hair and nails, and the most frequently found causative agent is Trichophyton rubrum. The disease is very common and often recurring, and it is therefore difficult to eradicate. To...
Antifungals Dermatophytes Explanted porcine skin Skin infection model Trichophyton rubrum /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/2400/2402 name=Applied Microbiology and Biotechnology /dk/atira/pure/subjectarea/asjc/1100/1102 name=Agronomy and Crop Science /dk/atira/pure/subjectarea/asjc/3400/3401 name=veterinary (miscalleneous) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Evaluation of an explanted porcine skin model to investigate infection with the dermatophyte Trichophyton rubrum.
Dermatophytosis is a fungal infection of skin, hair and nails, and the most frequently found causative agent is Trichophyton rubrum. The disease is very common and often recurring, and it is therefore difficult to eradicate. To...
Antifungals Dermatophytes Explanted porcine skin Skin infection model Trichophyton rubrum /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/2400/2402 name=Applied Microbiology and Biotechnology /dk/atira/pure/subjectarea/asjc/1100/1102 name=Agronomy and Crop Science /dk/atira/pure/subjectarea/asjc/3400/3401 name=veterinary (miscalleneous) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
A microtiter plate-based quantitative method to monitor the growth rate of dermatophytes and test antifungal activity
Dermatophytosis is one of the most common superficial fungal infections, which is mainly caused by filamentous fungi such as Trichophyton species. A challenging aspect in dermatophyte research is the lack of a straightforward...
A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
Sarah F. Cordery, Alistair Taverner, Ima E. Ridzwan, Richard H. Guy, M. Begona Delgado-Charro, Stephen M. Husbands, Christopher P. Bailey
Jul 01, 2014
Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy...
A microtiter plate-based quantitative method to monitor the growth rate of dermatophytes and test antifungal activity
Dermatophytosis is one of the most common superficial fungal infections, which is mainly caused by filamentous fungi such as Trichophyton species. A challenging aspect in dermatophyte research is the lack of a straightforward...
Dermatopharmacokinetics
The dermatopharmacokinetic methodology, in which tape stripping of the stratum corneum (SC) is used to access the amount of drug accumulated in the skin barrier, has been proposed for the quantification of topical drug...
Phosphate Loading does not improve 30-km cycling time-trial performance in trained cyclists
Harry Pope, Max Davis, Begona Delgado-Charro, Oliver Peacock, Javier Gonzalez, James A. Betts
Mar 01, 2023
Phosphate is integral to numerous metabolic processes, several of which strongly predict exercise performance (i.e., cardiac function, oxygen transport, and oxidative metabolism). Evidence regarding phosphate loading is...
Phosphate Loading does not improve 30-km cycling time-trial performance in trained cyclists
Harry Pope, Max Davis, Begona Delgado-Charro, Oliver Peacock, Javier Gonzalez, James A. Betts
Mar 01, 2023
Phosphate is integral to numerous metabolic processes, several of which strongly predict exercise performance (i.e., cardiac function, oxygen transport, and oxidative metabolism). Evidence regarding phosphate loading is...
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
Dermatopharmacokinetics
The dermatopharmacokinetic methodology, in which tape stripping of the stratum corneum (SC) is used to access the amount of drug accumulated in the skin barrier, has been proposed for the quantification of topical drug...
Trans-scleral iontophoretic delivery of low molecular weight therapeutics
S Güngör, M Begona Delgado-Charro, B Ruiz-Perez, W Schubert, P Isom, P Moslem, M A Patane, Richard H Guy
Oct 01, 2010
The fundamental understanding of ocular drug delivery using iontophoresis is not at the same level as that for transdermal electrotransport. Research has therefore been undertaken to characterise the electrical properties of the...
A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
Sarah F. Cordery, Alistair Taverner, Ima E. Ridzwan, Richard H. Guy, M. Begona Delgado-Charro, Stephen M. Husbands, Christopher P. Bailey
Jul 01, 2014
Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy...
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
Trans-scleral iontophoretic delivery of low molecular weight therapeutics
S Güngör, M Begona Delgado-Charro, B Ruiz-Perez, W Schubert, P Isom, P Moslem, M A Patane, Richard H Guy
Oct 01, 2010
The fundamental understanding of ocular drug delivery using iontophoresis is not at the same level as that for transdermal electrotransport. Research has therefore been undertaken to characterise the electrical properties of the...
Objective assessment of nanoparticle disposition in mammalian skin after topical exposure
Christopher S. J. Campbell, L. Rodrigo Contreras-Rojas, Begona Delgado-Charro, Richard H. Guy
Aug 20, 2012
The use of nanoparticles as formulation components of topical drug delivery systems for the skin has been widely investigated in the literature. Because of the conflicting conclusions resulting from these studies concerning the...
Objective assessment of nanoparticle disposition in mammalian skin after topical exposure
Christopher S. J. Campbell, L. Rodrigo Contreras-Rojas, Begona Delgado-Charro, Richard H. Guy
Aug 20, 2012
The use of nanoparticles as formulation components of topical drug delivery systems for the skin has been widely investigated in the literature. Because of the conflicting conclusions resulting from these studies concerning the...
Iontophoretic transdermal sampling of iohexol as a noninvasive tool to assess glomerular filtration rate
Asma Djabri, William van’t Hoff, Penelope Brock, Ian C.K. Wong, Richard Guy, Begona Delgado-Charro
Feb 01, 2015
Purpose
To explore the potential of non-invasive reverse iontophoresis transdermal extraction of iohexol as a marker of glomerular filtration rate.
Methods
A series of in vitro experiments were...
To explore the potential of non-invasive reverse iontophoresis transdermal extraction of iohexol as a marker of glomerular filtration rate.
Methods
A series of in vitro experiments were...
Iontophoretic transdermal sampling of iohexol as a noninvasive tool to assess glomerular filtration rate
Asma Djabri, William van’t Hoff, Penelope Brock, Ian C.K. Wong, Richard Guy, Begona Delgado-Charro
Feb 01, 2015
Purpose
To explore the potential of non-invasive reverse iontophoresis transdermal extraction of iohexol as a marker of glomerular filtration rate.
Methods
A series of in vitro experiments were...
To explore the potential of non-invasive reverse iontophoresis transdermal extraction of iohexol as a marker of glomerular filtration rate.
Methods
A series of in vitro experiments were...
Textile-based non-invasive lithium drug monitoring
Mona N Sweilam, Sarah Cordery, Stella Totti, Eirini G Velliou, Paola Campagnolo, John R Varcoe, Begona Delgado-Charro, Carol Crean
Feb 15, 2020
Flexible wearable chemical sensors are emerging tools which target diagnosis and monitoring of medical conditions. One of the potential applications of wearable chemical sensors is therapeutic drug monitoring for drugs that...
biocompatibility Interstitial fluid ion-selective electrode Lithium drug monitoring Non-invasive wearable sensor Reverse iontophoresis /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/1300/1304 name=Biophysics /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/1600/1603 name=Electrochemistry
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