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Results: 1241
Alemtuzumab CARE-MS II 5-year follow-up
Alasdair J Coles, Jeffrey A Cohen, Edward J Fox, Gavin Giovannoni, Hans-Peter Hartung, Eva Havrdova, Sven Schippling, Krzysztof W Selmaj, Anthony Traboulsee, D Alastair S Compston, David H Margolin, Karthinathan Thangavelu, Madalina C Chirieac, Darlene Jody, Panos Xenopoulos, Richard J Hogan, Michael A Panzara, Douglas L Arnold, CARE-MS II and CAMMS03409 Investigators
Dec 11, 2017
OBJECTIVE: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy. METHODS: In the 2-year Comparison of Alemtuzumab and Rebif...
The “Edutab Box”
Tatsuro Furuya, Kazutaka Mizukoshi, Yoshiaki Mizuochi, Yuto Omae, Takayuki Oshima, Norihisa Sakakibara, Hirotaka Takahashi, Kazuhiro Yatsushiro
Dec 27, 2019
Collaborative/active learning is a notably effective educational method. Since tablet terminals are now being widely used in the educational field, it is being possible to use tablet terminals for collaborative/active learning....
Published by: IGI Global Scientific Publishing
Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS.
Lina A Dahabiyeh, David Tooth, Robin W Carrell, Randy J Read, Yahui Yan, Fiona Broughton Pipkin, David A Barrett
Dec 11, 2018
Angiotensinogen (AGT) is a critical protein in the renin-angiotensin-aldosterone system and may have an important role in the pathogenesis of pre-eclampsia. The disulphide linkage between cysteines 18 and 138 has a key role in...
MS in South Asians in England
Richard S Nicholas, Vassiliki Kostadima, Maya Hanspal, Benjamin R Wakerley, Ruhena Sergeant, Saskia Decuypere, Omar Malik, Rosemary J Boyton, Daniel M Altmann
Sep 29, 2016
BACKGROUND: Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions can...
LC–MS Lipidomics
Typical lipidomics methods incorporate a liquid−liquid extraction with LC−MS quantitation; however, the classic sample extraction methods are not high-throughput and do not perform well at extracting the full range of lipids...
Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC-MS/MS approach
Job Tchoumtchoua, Maria Halabalaki, Evangelos Gikas, Anthony Tsarbopoulos, Nikoletta Fotaki, Lucy Liu, Sangkil Nam, Richard Jove, Leandros A. Skaltsounis
Feb 05, 2019
Indirubins represent a group of natural and synthetic products with bio-activities against numerous human cancer cell lines acting by inhibiting protein kinases. The natural sources of indirubins are plants of Isatis sp....
6BIO Pharmacokinetics Plasma Quantitation UHPLC-Orbitrap MS /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1607 name=Spectroscopy /dk/atira/pure/subjectarea/asjc/1300/1308 name=Clinical Biochemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Functionalized graphene oxide tablets for sample preparation of drugs in biological fluids
Zeynab Zohdijamil, Mahdi Hashemi, Abbi Abdel-Rehim, Karthik Laxman, Abdusalam Uheida, Joydeep Dutta, Mohamed Abdel-Rehim
Jun 04, 2021
In this work, graphene oxide-based tablets (GO-Tabs) were prepared by applying a thin layer of functionalized GO on a polyethylene substrate. The GO was functionalized with amine groups (-NH2 ) by poly(ethylene...
Organoid Sample Preparation and Extraction for LC-MS Peptidomics.
Emily L Miedzybrodzka, Rachel E Foreman, Sam G Galvin, Pierre Larraufie, Amy L George, Deborah A Goldspink, Frank Reimann, Fiona M Gribble, Richard G Kay
Mar 18, 2021
This protocol describes the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry (LC-MS). Currently, most peptides are quantified by ELISA...
Effects of Different Land-Use Types on the Space Use of the Woodland Box Turtle
Sydney Grant
Jan 01, 0001
Human land use change has resulted in extensive habitat loss, degradation, and fragmentation, threatening biodiversity worldwide. The population of woodland box turtles (Terrapene carolina carolina) has declined because of land...
Published by: Winthrop University
Conservation Biology Class Seeks to Save Box Turtles From Urbanization
Winthrop University
Jan 01, 0001
HIGHLIGHTS They received three grants - from the North American Box Turtle Conservation Committee, Sigma Xi and the Winthrop Research Council - and used the funds to purchase radio transmitters.
Published by: Winthrop University
Alemtuzumab improves preexisting disability in active relapsing-remitting MS patients
G Giovannoni, JA Cohen, AJ Coles, H-P Hartung, E Havrdova, KW Selmaj, DH Margolin, SL Lake, SM Kaup, MA Panzara, DAS Compston, CARE-MS II Investigators
Jan 11, 2017
Adjuvants Immunologic Alemtuzumab Analysis of Variance Antibodies Monoclonal Humanized Antineoplastic Agents Disability Evaluation Disabled Persons Female Humans Interferon-beta Kaplan-Meier Estimate Longitudinal Studies Male Multiple Sclerosis Relapsing-Remitting Severity of Illness Index Treatment Outcome
Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands.
Fay Probert, Tianrong Yeo, Yifan Zhou, Megan Sealey, Siddharth Arora, Jacqueline Palace, Timothy DW Claridge, Rainer Hillenbrand, Johanna Oechtering, Jens Kuhle, David Leppert, Daniel C Anthony
Feb 18, 2022
BACKGROUND: Inclusion of cerebrospinal fluid (CSF) oligoclonal IgG bands (OCGB) in the revised McDonald criteria increases the sensitivity of diagnosis when dissemination in time (DIT) cannot be proven. While OCGB negative...
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Duuamene Nyimanu, Richard G Kay, Petra Sulentic, Rhoda E Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M Gribble, Joseph Cheriyan, Janet J Maguire, Anthony P Davenport
Dec 05, 2019
[Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its stability...
Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC-MS/MS approach
Job Tchoumtchoua, Maria Halabalaki, Evangelos Gikas, Anthony Tsarbopoulos, Nikoletta Fotaki, Lucy Liu, Sangkil Nam, Richard Jove, Leandros A. Skaltsounis
Feb 05, 2019
Indirubins represent a group of natural and synthetic products with bio-activities against numerous human cancer cell lines acting by inhibiting protein kinases. The natural sources of indirubins are plants of Isatis sp....
6BIO Pharmacokinetics Plasma Quantitation UHPLC-Orbitrap MS /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1607 name=Spectroscopy /dk/atira/pure/subjectarea/asjc/1300/1308 name=Clinical Biochemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.
Hendrik J Kuiken, David A Egan, Heike Laman, Rene Bernards, Roderick L Beijersbergen, Annette M Dirac
Aug 03, 2018
The nuclear factor κB (NF-κB) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is...
Adaptor Proteins Signal Transducing F-Box Proteins Gene Expression Regulation HEK293 Cells Humans Immunoblotting Immunoprecipitation Inhibitor of Apoptosis Proteins NF-kappa B Nuclear Pore Complex Proteins RNA Small Interfering RNA-Binding Proteins Signal Transduction Tumor Necrosis Factor-alpha Ubiquitination
Published by: J Cell Mol Med
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr 1 ]apelin-13 in humans
Duuamene Nyimanu, Richard G. Kay, Petra Sulentic, Rhoda E. Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M. Gribble, Joseph Cheriyan, Janet J. Maguire, Anthony P. Davenport
Dec 26, 2020
Abstract: [Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its...
Superior MRI outcomes with alemtuzumab compared with subcutaneous interferon β-1a in MS
DL Arnold, E Fisher, VV Brinar, JA Cohen, AJ Coles, G Giovannoni, H-P Hartung, E Havrdova, KW Selmaj, M Stojanovic, HL Weiner, SL Lake, DH Margolin, DR Thomas, MA Panzara, DAS Compston, CARE-MS I and CARE-MS II Investigators
Jan 06, 2017
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS
Tashinga E Bapiro, Frances M Richards, Mae A Goldgraben, Kenneth P Olive, Basetti Madhu, Kristopher K Frese, Natalie Cook, Michael A Jacobetz, Donna-Michelle Smith, David A Tuveson, John R Griffiths, Duncan I Jodrell
Nov 30, 2017
PURPOSE: To develop a sensitive analytical method to quantify gemcitabine (2',2'-difluorodeoxycytidine, dFdC) and its metabolites 2',2'-difluorodeoxyuridine (dFdU) and 2',2'-difluorodeoxycytidine-5'-triphosphate (dFdCTP)...
S-Box Construction Method Based on the Combination of Quantum Chaos and PWLCM Chaotic Map
For a security system built on symmetric-key cryptography algorithms, the substitution box (S-box) plays a crucial role to resist cryptanalysis. In this article, we incorporate quantum chaos and PWLCM chaotic map into a new...
Published by: IGI Global Scientific Publishing
Flange local buckling of pultruded GFRP box beams
An experimental program investigating the flange local buckling (FLB) behavior of pGFRP box-sections is reported. The commonly accepted design equation based on plate theory was validated although importance of accurate...
Participation Analysis in Impedance Models
This paper develops a grey-box approach to small-signal stability analysis of complex power systems that facilitates root-cause tracing without requiring disclosure of the full details of the internal control structure of...
Flange local buckling of pultruded GFRP box beams
An experimental program investigating the flange local buckling (FLB) behavior of pGFRP box-sections is reported. The commonly accepted design equation based on plate theory was validated although importance of accurate...
Participation Analysis in Impedance Models
This paper develops a grey-box approach to small-signal stability analysis of complex power systems that facilitates root-cause tracing without requiring disclosure of the full details of the internal control structure of...
The <em>Bacillus</em> BioBrick Box
Jara Radeck, Korinna Kraft, Julia Bartels, Tamara Cikovic, Franziska Dürr, Jennifer Emenegger, Simon Kelterborn, Christopher Sauer, Georg Fritz, Susanne Gebhard, Thorsten Mascher
Jan 01, 2013
Background
Standardized and well-characterized genetic building blocks are a prerequisite for the convenient and reproducible assembly of novel genetic modules and devices. While numerous standardized parts exist for...
Standardized and well-characterized genetic building blocks are a prerequisite for the convenient and reproducible assembly of novel genetic modules and devices. While numerous standardized parts exist for...
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