Search
Results: 34
Anti-thrombotic efficacy of S007-867
Ankita Misra, Prem Prakash, Hobby Aggarwal, Priyanka Dhankani, Sachin Kumar, Chandra Prakash Pandey, Nicholas Pugh, Dominique Bihan, Manoj Kumar Barthwal, Richard W Farndale, Dinesh Kumar Dikshit, Madhu Dikshit
Mar 15, 2018
Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867 is a novel synthetic inhibitor of collagen-induced platelet aggregation. It has shown...
Blood Flow Velocity Collagen Hemostasis Platelet Activation Thrombosis Animals Aspirin Blood Coagulation Chlorides Clopidogrel Dose-Response Relationship Drug Ferric Compounds Fibrinolytic Agents Male Mice Piperidines Platelet Adhesiveness Platelet Aggregation Pyrrolidines Rats Rats Sprague-Dawley Thrombosis
Apc Min/+ tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon
Abstract: Topographical variations of metabolite concentrations have been reported in the duodenum, jejunum and ileum of the small intestine, and in human intestinal tumours from those regions, but there are no published...
Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra.
METHODS: We quantified 378 HRMAS 1H NMR spectra of human brain tumours (132 glioblastomas, 101 astrocytomas, 75 meningiomas, 37 oligodendrogliomas and 33 metastases) from the eTumour database and looked for metabolic...
Intelligent Information Retrieval for Reducing Missed Cancer and Improving the Healthcare System
This study presents an intelligent information retrieval system that will effectively extract useful information from breast cancer datasets and utilized that information to build a classification model. The proposed model will...
Published by: IGI Global Scientific Publishing
Apc Min/+ tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon
Abstract: Topographical variations of metabolite concentrations have been reported in the duodenum, jejunum and ileum of the small intestine, and in human intestinal tumours from those regions, but there are no published...
Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.
BACKGROUND: Acquiring clinically annotated, spatially stratified tissue samples from human glioblastoma (GBM) is compromised by haemorrhage, brain shift and subjective identification of 'normal' brain. We tested the use of...
The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours
Adaptive laboratory evolution of the fast-growing cyanobacterium Synechococcus elongatus PCC 11801 for improved solvent tolerance.
Vaibhav Srivastava, Ruth Amanna, Stephen JL Rowden, Shinjinee Sengupta, Swati Madhu, Christopher J Howe, Pramod P Wangikar
Jan 13, 2021
Cyanobacteria hold promise as cell factories for the photoautotrophic conversion of carbon dioxide to useful chemicals. For the eventual commercial viability of such processes, cyanobacteria need to be engineered for (i)...
ApcMin/+ tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon.
The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours
Loreta M Rodrigues, Santiago Uribe-Lewis, Basetti Madhu, Davina J Honess, Marion Stubbs, John R Griffiths
May 05, 2017
Abstract
Background
Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases;...
Survival Pathways of HIF-Deficient Tumour Cells
Monika A. Golinska, Marion Stubbs, Adrian L. Harris, Laszlo G. Boros, Madhu Basetti, Dominick J. O. McIntyre, John R. Griffiths
Dec 08, 2022
article HIF-1β deficiency Hepa-1 c4 cells hypoxia response 1 2-13C2-labelled glucose TCA fatty acid oxidation AMP-activated kinase phospho-p38 MAPK PPARα PGC-1α
Published by: MDPI
An exploratory qualitative study of the prevention of road traffic collisions and neurotrauma in India
Santhani M Selveindran, Gurusinghe DN Samarutilake, K Madhu Narayana Rao, Jogi V Pattisapu, Christine Hill, Angelos G Kolias, Rajesh Pathi, Peter JA Hutchinson, MV Vijaya Sekhar
Jun 11, 2021
BACKGROUND: Despite current preventative strategies, road traffic collisions (RTCs) and resultant neurotrauma remain a major problem in India. This study seeks to explore local perspectives in the context within which RTCs take...
Survival Pathways of HIF-Deficient Tumour Cells
Monika A Golinska, Marion Stubbs, Adrian L Harris, Laszlo G Boros, Madhu Basetti, Dominick JO McIntyre, John R Griffiths
Jan 04, 2023
The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 therapy? We studied metabolic and...
Teleophthalmology
Sweta Sneha, Avijit Singh, Anshu Singh, Madhu Bhadauria, Christopher Burgess, Lisero Mugula
Dec 22, 2022
As a result of COVID-19, a new approach for delivering eye care services to rural underprivileged areas were needed to improve eye disease outcomes. Sitapur Eye Hospital used a door-to-door model of medical delivery to alleviate...
Published by: IGI Global Scientific Publishing
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS
Tashinga E Bapiro, Frances M Richards, Mae A Goldgraben, Kenneth P Olive, Basetti Madhu, Kristopher K Frese, Natalie Cook, Michael A Jacobetz, Donna-Michelle Smith, David A Tuveson, John R Griffiths, Duncan I Jodrell
Nov 30, 2017
PURPOSE: To develop a sensitive analytical method to quantify gemcitabine (2',2'-difluorodeoxycytidine, dFdC) and its metabolites 2',2'-difluorodeoxyuridine (dFdU) and 2',2'-difluorodeoxycytidine-5'-triphosphate (dFdCTP)...
Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.
TE Bapiro, KK Frese, A Courtin, JL Bramhall, B Madhu, N Cook, A Neesse, JR Griffiths, DA Tuveson, DI Jodrell, FM Richards
Nov 16, 2017
BACKGROUND: The modest benefits of gemcitabine (dFdC) therapy in patients with pancreatic ductal adenocarcinoma (PDAC) are well documented, with drug delivery and metabolic lability cited as important contributing factors. We...
An exploratory qualitative study of the prevention of road traffic collisions and neurotrauma in India
Santhani M Selveindran, Gurusinghe D. N. Samarutilake, K. Madhu Narayana Rao, Jogi V. Pattisapu, Christine Hill, Angelos G. Kolias, Rajesh Pathi, Peter J. A. Hutchinson, M. V. Vijaya Sekhar
Mar 30, 2021
Abstract: Background: Despite current preventative strategies, road traffic collisions (RTCs) and resultant neurotrauma remain a major problem in India. This study seeks to explore local perspectives in the context within which...
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.
Jingwei Sim, Andrew S Cowburn, Asis Palazon, Basetti Madhu, Petros A Tyrakis, David Macías, David M Bargiela, Sandra Pietsch, Michael Gralla, Colin E Evans, Thaksaon Kittipassorn, Yu CJ Chey, Cristina M Branco, Helene Rundqvist, Daniel J Peet, Randall S Johnson
Apr 10, 2018
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting...
HIF Hypoxia metabolism Adaptation Physiological Animals Cell Hypoxia Gene Expression Regulation Glycolysis Hypoxia-Inducible Factor-Proline Dioxygenases Male Mice Mice Inbred C57BL Mixed Function Oxygenases Oxygen Oxygen Consumption Procollagen-Proline Dioxygenase Signal Transduction Transcription Genetic Von Hippel-Lindau Tumor Suppressor Protein
Translating In Vivo Metabolomic Analysis of Succinate Dehydrogenase–Deficient Tumors Into Clinical Utility
Purpose Mutations in the mitochondrial enzyme succinate dehydrogenase (SDH) subunit genes are associated with a wide spectrum of tumors, including pheochromocytomas and paragangliomas...
Ruth T Casey, Mary A McLean, Basetti Madhu, Benjamin G Challis, Rogier Ten Hoopen, Thomas Roberts, Graeme R Clark, Deborah Pitfield, Helen L Simpson, Venkata R Bulusu, Kieren Allinson, Lisa Happerfield, Soo-Mi Park, Alison Marker, Olivier Giger, Eamonn R Maher, Ferdia A Gallagher
Jul 02, 2018
SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice
Ruth T. Casey, Rogier Ten Hoopen, Eguzkine Ochoa, Benjamin G. Challis, James Whitworth, Philip S. Smith, Jose Ezequiel Martin, Graeme R. Clark, Fay Rodger, Mel Maranian, Kieren Allinson, Basetti Madhu, Thomas Roberts, Luis Campos, Joanne Anstee, Soo-Mi Park, Alison Marker, Colin Watts, Venkata R. Bulusu, Olivier T. Giger, Eamonn R. Maher
Jul 14, 2020
Abstract: The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL), wild type gastrointestinal stromal tumour...
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.
Vincent Zecchini, Basetti Madhu, Roslin Russell, Nelma Pértega-Gomes, Anne Warren, Edoardo Gaude, Joana Borlido, Rory Stark, Heather Ireland-Zecchini, Roheet Rao, Helen Scott, Joan Boren, Charlie Massie, Mohammad Asim, Kevin Brindle, John Griffiths, Christian Frezza, David E Neal, Ian G Mills
Nov 16, 2017
Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible...
adaptor Hypoxia metabolism Prostate Transcription Arrestins Chromatin Immunoprecipitation Fluorescent Antibody Technique Fumarate Hydratase Gas Chromatography-Mass Spectrometry Gene Expression Profiling Humans Hypoxia-Inducible Factor 1 alpha Subunit Immunoblotting Immunohistochemistry Magnetic Resonance Spectroscopy Male Metabolic Networks and Pathways Metabolomics Models Biological Prostatic Neoplasms RNA Interference Succinate Dehydrogenase Tissue Array Analysis beta-Arrestin 1 beta-Arrestins
|
|< |
< |
1 |