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Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort.
Evolutionarily Successful Asian 1 Dengue Virus 2 Lineages Contain One Substitution in Envelope That Increases Sensitivity to Polyclonal Antibody Neutralization.
Chunling Wang, Leah C Katzelnick, Magelda Montoya, Kien Duong Thi Hue, Cameron P Simmons, Eva Harris
Feb 11, 2016
Cambodia Vietnam dengue virus envelope protein evolution FITNESS Genotype lineage neutralizing antibodies Amino Acid Substitution Antibodies Neutralizing Antibodies Viral Biological Evolution Cloning Molecular dengue dengue virus evolution Molecular Gene Expression Regulation Viral Humans Phylogeny Serotyping Viral Envelope Proteins
Dengue viruses cluster antigenically but not as discrete serotypes.
Leah C Katzelnick, Judith M Fonville, Gregory D Gromowski, Jose Bustos Arriaga, Angela Green, Sarah L James, Louis Lau, Magelda Montoya, Chunling Wang, Laura A VanBlargan, Colin A Russell, Hlaing Myat Thu, Theodore C Pierson, Philippe Buchy, John G Aaskov, Jorge L Muñoz-Jordán, Nikos Vasilakis, Robert V Gibbons, Robert B Tesh, Albert DME Osterhaus, Ron AM Fouchier, Anna Durbin, Cameron P Simmons, Edward C Holmes, Eva Harris, Stephen S Whitehead, Derek J Smith
Sep 08, 2015
Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect.
Isabell M Meier, Estrella R Montoya, Hannah Spencer, Sofia C Orellana, Mariët van Buuren, Jack van Honk, Peter A Bos
Jan 27, 2023
Sensitivity for rewarding cues and distress signals from children is fundamental to human caregiving and modulated by the neuropeptide oxytocin. In a functional magnetic resonance imaging study, we investigated whether oxytocin...
Incidence of maternal peripartum infection
Susannah L Woodd, Ana Montoya, Maria Barreix, Li Pi, Clara Calvert, Andrea M Rehman, Doris Chou, Oona MR Campbell
Dec 10, 2019
BACKGROUND: Infection is an important, preventable cause of maternal morbidity, and pregnancy-related sepsis accounts for 11% of maternal deaths. However, frequency of maternal infection is poorly described, and, to our...
Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect.
Isabell M Meier, Estrella R Montoya, Hannah Spencer, Sofia C Orellana, Mariët van Buuren, Jack van Honk, Peter A Bos
Nov 26, 2022
Sensitivity for rewarding cues and distress signals from children is fundamental to human caregiving and modulated by the neuropeptide oxytocin. In a functional magnetic resonance imaging study, we investigated whether oxytocin...
Double-Framed Thin Elastomer Devices.
Valeria Criscuolo, Nerio Andrés Montoya, Andrea Lo Presti, Luigi G Occhipinti, Paolo Antonio Netti, Raffaele Vecchione, Christian Falconi
Nov 12, 2020
Elastomers and, in particular, polydimethylsiloxane (PDMS) are widely adopted as biocompatible mechanically compliant substrates for soft and flexible micro-nanosystems in medicine, biology, and engineering. However, several...
Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization.
Timothy J Sargeant, Bethan Lloyd-Lewis, Henrike K Resemann, Antonio Ramos-Montoya, Jeremy Skepper, Christine J Watson
Oct 21, 2014
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
Rebecca L. Lloyd, Paul W. G. Wijnhoven, Antonio Ramos-Montoya, Zena Wilson, Giuditta Illuzzi, Katarzyna Falenta, Gemma N. Jones, Neil James, Christophe D. Chabbert, Jonathan Stott, Emma Dean, Alan Lau, Lucy A. Young
Jun 18, 2020
Abstract: The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits PARP1/2 enzymatic activity and traps PARP1 on DNA...
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells.
Rebecca L Lloyd, Paul WG Wijnhoven, Antonio Ramos-Montoya, Zena Wilson, Giuditta Illuzzi, Katarzyna Falenta, Gemma N Jones, Neil James, Christophe D Chabbert, Jonathan Stott, Emma Dean, Alan Lau, Lucy A Young
May 23, 2021
The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits PARP1/2 enzymatic activity and traps PARP1 on DNA at...
Identification of potential therapeutic targets in prostate cancer through a cross-species approach.
Sarah Jurmeister, Antonio Ramos-Montoya, Chiranjeevi Sandi, Nelma Pértega-Gomes, Karan Wadhwa, Alastair D Lamb, Mark J Dunning, Jan Attig, Jason S Carroll, Lee GD Fryer, Sérgio L Felisbino, David E Neal
Mar 28, 2018
Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development...
MELK cross‐species analysis Mouse models new cancer targets prostate cancer Animals Carcinogenesis Cell Line Tumor Cell Proliferation Cell Survival Disease Progression Down-Regulation Gene Expression Profiling Gene Expression Regulation Neoplastic Genome Humans Male Mice Molecular Targeted Therapy Naphthyridines Neoplasm Invasiveness Phenotype Phosphorylation Prostatic Neoplasms Protein Serine-Threonine Kinases Species Specificity Spindle Apparatus Stathmin Transcriptome
Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family.
Peter J Kullar, Aurora Gomez-Duran, Payam A Gammage, Caterina Garone, Michal Minczuk, Zoe Golder, Janet Wilson, Julio Montoya, Sanna Häkli, Mikko Kärppä, Rita Horvath, Kari Majamaa, Patrick F Chinnery
Apr 26, 2018
The m.1555A>G mtDNA variant causes maternally inherited deafness, but the reasons for the highly variable clinical penetrance are not known. Exome sequencing identified a heterozygous start loss mutation in SSBP1, encoding the...
Genetics Hearing Mitochondrial Diseases muscle disease neurodegeneration Adolescent Child Child Preschool DNA Mutational Analysis DNA-Binding Proteins Electron Transport Complex II Electron Transport Complex IV Family Health Female FIBROBLASTS Hearing Loss Heterozygote Humans Infant Male Mitochondrial Diseases Mitochondrial Proteins Mitochondrial Proton-Translocating ATPases Muscle Skeletal Mutation Young Adult
Adaptive Introgression across Semipermeable Species Boundaries between Local Helicoverpa zea and Invasive Helicoverpa armigera Moths.
Wendy A Valencia-Montoya, Samia Elfekih, Henry L North, Joana I Meier, Ian A Warren, Wee Tek Tay, Karl HJ Gordon, Alexandre Specht, Silvana V Paula-Moraes, Rahul Rane, Tom K Walsh, Chris D Jiggins
Jul 29, 2020
Hybridization between invasive and native species has raised global concern, given the dramatic increase in species range shifts and pest outbreaks due to anthropogenic dispersal. Nevertheless, secondary contact between sister...
A glycolytic phenotype is associated with prostate cancer progression and aggressiveness
Nelma Pertega-Gomes, Sergio Felisbino, Charlie E Massie, Jose R Vizcaino, Ricardo Coelho, Chiranjeevi Sandi, Susana Simoes-Sousa, Sarah Jurmeister, Antonio Ramos-Montoya, Mohammad Asim, Maxine Tran, Elsa Oliveira, Alexandre Lobo da Cunha, Valdemar Maximo, Fatima Baltazar, David E Neal, Lee GD Fryer
Jun 02, 2015
cell metabolism metabolic targets monocarboxylate transporters poor prognosis markers prostate cancer Animals Antineoplastic Agents Cell Line Tumor Cell Proliferation Disease Progression Drug Design Gene Expression Regulation Neoplastic Glycolysis Humans Lactic Acid Male Mice Transgenic Molecular Targeted Therapy Monocarboxylic Acid Transporters Neoplasm Staging Phenotype Prostatic Neoplasms RNA Interference Time Factors Transfection Tumor Burden
Independence of HIF1a and androgen signaling pathways in prostate cancer
Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills, David E. Neal
Jun 06, 2020
Independence of HIF1a and androgen signaling pathways in prostate cancer.
Maxine GB Tran, Becky AS Bibby, Lingjian Yang, Franklin Lo, Anne Y Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine ML West, Ian G Mills, David E Neal
Jul 14, 2020
BACKGROUND: Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progression to...
Androgen signaling HIF1a signaling Hypoxia prostate cancer Androgen Antagonists Androgens Animals Apoptosis Biomarkers Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Male Mice Prostatic Neoplasms Receptors Androgen Signal Transduction Transcriptional Activation Tumor Cells Cultured Xenograft Model Antitumor Assays
Independence of HIF1a and androgen signaling pathways in prostate cancer
Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills, David E. Neal
May 25, 2021
HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Charles E Massie, Inmaculada Spiteri, Helen Ross-Adams, Hayley Luxton, Jonathan Kay, Hayley C Whitaker, Mark J Dunning, Alastair D Lamb, Antonio Ramos-Montoya, Daniel S Brewer, Colin S Cooper, Rosalind Eeles, UK Prostate ICGC Group, Anne Y Warren, Simon Tavaré, David E Neal, Andy G Lynch
Mar 12, 2015
AR ERG HES5 HES6 Notch epigenetics Methylation prostate cancer Basic Helix-Loop-Helix Transcription Factors Carcinogenesis Cell Line Tumor DNA Methylation Epigenesis Genetic Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Male Promoter Regions Genetic Prostatic Neoplasms Repressor Proteins Trans-Activators Transcriptional Regulator ERG
The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.
Greg L Shaw, Hayley Whitaker, Marie Corcoran, Mark J Dunning, Hayley Luxton, Jonathan Kay, Charlie E Massie, Jodi L Miller, Alastair D Lamb, Helen Ross-Adams, Roslin Russell, Adam W Nelson, Matthew D Eldridge, Andrew G Lynch, Antonio Ramos-Montoya, Ian G Mills, Angela E Taylor, Wiebke Arlt, Nimish Shah, Anne Y Warren, David E Neal
Nov 04, 2015
Androgen receptor Castration clinical trial Gene transcription Immunohistochemistry prostate cancer Estrogen Receptor alpha Gene Expression Profiling Gene Expression Regulation Neoplastic Hormone Antagonists Humans Immunohistochemistry Male Oligopeptides Preoperative Care Prostate Prostatectomy Prostatic Neoplasms Receptors Androgen Spectrum Analysis
Early science with the Large Millimetre Telescope
M Chavez-Dagostino, E Bertone, FCS de Miera, JP Marshall, GW Wilson, D Śanchez-Argüelles, DH Hughes, G Kennedy, O Vega, V de la Luz, WRF Dent, C Eiroa, AI Ǵomez-Ruiz, JS Greaves, S Lizano, R Ĺopez-Valdivia, E Mamajek, A Montaña, M Olmedo, I Rodríguez-Montoya, FP Schloerb, MS Yun, JA Zavala, M Zeballos
Apr 24, 2017
Integration of copy number and transcriptomics provides risk stratification in prostate cancer
H Ross-Adams, AD Lamb, MJ Dunning, S Halim, J Lindberg, CM Massie, LA Egevad, R Russell, A Ramos-Montoya, SL Vowler, NL Sharma, J Kay, H Whitaker, J Clark, R Hurst, VJ Gnanapragasam, NC Shah, AY Warren, CS Cooper, AG Lynch, R Stark, IG Mills, H Grönberg, DE Neal, CamCaP Study Group
Jul 21, 2015
Biochemical relapse Gene signature Genomics Personalised medicine Prognosis prostate cancer Risk stratification Adult Aged Aged 80 and over Cluster Analysis Cohort Studies Gene Dosage Gene Expression Profiling Gene Expression Regulation Neoplastic Genome Human Humans Male Middle Aged Prognosis Prostatic Neoplasms RNA Messenger Recurrence Reproducibility of Results Risk Factors Transcriptome
Nulling Data Reduction and On-Sky Performance of the Large Binocular Telescope Interferometer
D Defrre, PM Hinz, B Mennesson, WF Hoffmann, R Millan-Gabet, AJ Skemer, V Bailey, WC Danchi, EC Downey, O Durney, P Grenz, JM Hill, TJ McMahon, M Montoya, E Spalding, A Vaz, O Absil, P Arbo, H Bailey, G Brusa, G Bryden, S Esposito, A Gaspar, CA Haniff, GM Kennedy, JM Leisenring, L Marion, M Nowak, E Pinna, K Powell, A Puglisi, G Rieke, A Roberge, E Serabyn, R Sosa, K Stapeldfeldt, K Su, AJ Weinberger, MC Wyatt
Apr 24, 2017
Fumarate induces vesicular release of mtDNA to drive innate immunity
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M. N. Wortel, Jordan L. Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S. H. Costa, Gonçalo C. Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith Samarajiwa, Maxine Tran, Thomas Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Mar 15, 2023
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