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Results: 47
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Harry J Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S Howard, John Wharton, Benjamin Dunmore, Paul D Upton, Martin R Wilkins, Joshua B Edel, Beata Wojciak-Stothard
Nov 08, 2022
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell...
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Harry J Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S Howard, John Wharton, Benjamin Dunmore, Paul D Upton, Martin R Wilkins, Joshua B Edel, Beata Wojciak-Stothard
Dec 09, 2022
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell...
Is mere exposure enough? The effects of bilingual environments on infant cognitive development.
Bilinguals purportedly outperform monolinguals in non-verbal tasks of cognitive control (the 'bilingual advantage'). The most common explanation is that managing two languages during language production constantly draws upon...
Published by: Royal Society open science
Is mere exposure enough? The effects of bilingual environments on infant cognitive development.
Bilinguals purportedly outperform monolinguals in non-verbal tasks of cognitive control (the 'bilingual advantage'). The most common explanation is that managing two languages during language production constantly draws upon...
Early bilingual experience is associated with change detection ability in adults
Abstract: To adapt to their more varied and unpredictable (language) environments, infants from bilingual homes may gather more information (sample more of their environment) by shifting their visual attention more frequently....
Early bilingual experience is associated with change detection ability in adults.
To adapt to their more varied and unpredictable (language) environments, infants from bilingual homes may gather more information (sample more of their environment) by shifting their visual attention more frequently. However, it...
Relapse into opiate and crack cocaine misuse
Maike Klein
Dec 31, 2021
Aims: International statistics show that relapse rates associated with opiate and crack cocaine (OCC) misuse remain high. This has led to an increased scientific interest in the topic of relapse. However, there are limited...
Problematising ‘Recovery’ in Drug Policy within Great Britain
Drug strategies in the United Kingdom emphasize the notion of recovery, with the concept being central in England, Wales and Scotland. There are however tensions, with recovery being defined differently across jurisdictions. In...
Relapse into opiate and crack cocaine misuse
Maike Klein
Dec 31, 2021
Aims: International statistics show that relapse rates associated with opiate and crack cocaine (OCC) misuse remain high. This has led to an increased scientific interest in the topic of relapse. However, there are limited...
The use of body-mapping in interpretative phenomenological analyses
The increasing popularity of Interpretative Phenomenological Analysis
(IPA) in social research brings an increasing criticism about its validity,
robustness and, more recently, its lack of expressive features....
(IPA) in social research brings an increasing criticism about its validity,
robustness and, more recently, its lack of expressive features....
Problematising ‘Recovery’ in Drug Policy within Great Britain
Drug strategies in the United Kingdom emphasize the notion of recovery, with the concept being central in England, Wales and Scotland. There are however tensions, with recovery being defined differently across jurisdictions. In...
Leadership during a racial microaggression on campus
The study aimed at understanding students’ perspectives on university response to a racial microaggression on a campus. Responses were collected in the form of an online survey and analyzed using qualitative data analysis to...
The use of body-mapping in interpretative phenomenological analyses
The increasing popularity of Interpretative Phenomenological Analysis
(IPA) in social research brings an increasing criticism about its validity,
robustness and, more recently, its lack of expressive features....
(IPA) in social research brings an increasing criticism about its validity,
robustness and, more recently, its lack of expressive features....
Multiple relapses into opiate and crack misuse among people in recovery
Relapsing multiple times back into opiate and crack cocaine misuse significantly increases the risk for overdose death, of which rates continue to soar worldwide. This study aims to provide an in-depth understanding of opiate...
Relapse Interpretative Phenomenological Analysis (IPA) Addiction opiates crack /dk/atira/pure/subjectarea/asjc/3200/3207 name=Social Psychology /dk/atira/pure/subjectarea/asjc/3200/3203 name=Clinical Psychology /dk/atira/pure/subjectarea/asjc/3300/3308 name=Law /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Multiple relapses into opiate and crack misuse among people in recovery
Relapsing multiple times back into opiate and crack cocaine misuse significantly increases the risk for overdose death, of which rates continue to soar worldwide. This study aims to provide an in-depth understanding of opiate...
Relapse Interpretative Phenomenological Analysis (IPA) Addiction opiates crack /dk/atira/pure/subjectarea/asjc/3200/3207 name=Social Psychology /dk/atira/pure/subjectarea/asjc/3200/3203 name=Clinical Psychology /dk/atira/pure/subjectarea/asjc/3300/3308 name=Law /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Leadership during a racial microaggression on campus
The study aimed at understanding students’ perspectives on university response to a racial microaggression on a campus. Responses were collected in the form of an online survey and analyzed using qualitative data analysis to...
Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules.
The repertoire of peptides displayed at the cell surface by MHC I molecules is shaped by two intracellular peptide editors, tapasin and TAPBPR. While cell-free assays have proven extremely useful in identifying the function of...
Human Capital Development Practices and Career Success
Silvia Bagdadli, Martina Gianecchini, Maike Andresen, Rick Cotton, Robert Kaše, Mila Lazarova, Adam Smale, Janine Bosak, Jon Briscoe, Katharina Chudzikowski, Silvia Dello Russo, Astrid Reichel
May 03, 2021
Employees can enhance their human capital through participation in organizationally-sponsored development activities. However, there is little research on the extent to which the effects of such practices vary depending on...
Career success country development development practices human capital Income Inequality /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/3300/3312 name=Sociology and Political Science /dk/atira/pure/subjectarea/asjc/3200/3200 name=General Psychology /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities name=SDG 10 - Reduced Inequalities
Still feeling employable with growing age? Exploring the moderating effects of developmental HR practices and country-level unemployment rates in the age – employability relationship
Silvia Dello Russo, Emma Parry, Janine Bosak, Maike Andresen, Eleni Apospori, Silvia Bagdadli, Katharina Chudzikowski, Michael Dickmann, Sonia Ferencikova, Martina Gianecchini, Tim (Douglas) Hall, Robert Kase, Mila Lazarova, Astrid Reichel
May 14, 2020
A compelling issue for organizations and societies at large is to ensure external employability of the workforce across workers’ entire work-life span. Using the frameworks of age norms, stereotyping and age meta-stereotypes, we...
The FASTK family proteins fine-tune mitochondrial RNA processing.
Akira Ohkubo, Lindsey Van Haute, Danielle L Rudler, Maike Stentenbach, Florian A Steiner, Oliver Rackham, Michal Minczuk, Aleksandra Filipovska, Jean-Claude Martinou
Jan 07, 2022
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Jul 30, 2021
Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT...
Animals Cell Death Cell Line Tumor Cell Survival Disease Progression Humans Immunohistochemistry Leukemia Lymphocytic Chronic B-Cell Mice Mice Transgenic Mitochondria Oxidative Phosphorylation Phosphatidylinositol 3-Kinases Phosphatidylinositol-3 4 5-Trisphosphate 5-Phosphatases Proto-Oncogene Proteins c-akt RNA Small Interfering RNA-seq Reactive Oxygen Species Signal Transduction Transplantation Homologous Xenograft Model Antitumor Assays
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