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N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of...

11C Carbamoylation Methyl isocyanate PET Radiochemistry

For over a decade, social networking has been ruling over the internet and plays a vital role in day-to-day life. However, for a new network to survive in this market, exclusivity is a necessity. As a result, the goal of this...

Diagnosis of COVID-19 pneumonia using patients’ chest X-Ray images is new but yet important task in the field of medicine. Researchers from different parts of the globe have developed many deep learning models to classify...

Health Information Systems Medicine and Healthcare Health Information Systems

Hepatic Artery Humans Liver Liver Transplantation Thrombosis Vascular Surgical Procedures

Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER...

Binding Sites Breast Neoplasms Cell Line Tumor Cell Proliferation Cytidine Cytidine Deaminase DNA DNA Damage DNA End-Joining Repair Deamination Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Humans Minor Histocompatibility Antigens Prognosis Protein Binding RNA Small Interfering Signal Transduction Survival Analysis Transcription Genetic Trefoil Factor-1 Tumor Suppressor Proteins

The conserved SecYEG protein-conducting channel and the accessory proteins SecDF-YajC and YidC constitute the bacterial holo-translocon (HTL), capable of protein-secretion and membrane-protein insertion. By employing an...

Binding Sites Cloning Molecular Cryoelectron Microscopy Escherichia coli Escherichia coli Proteins Gene Expression Genetic Vectors Membrane Transport Proteins Methanocaldococcus Models Molecular neutron diffraction Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Transport Recombinant Proteins SEC Translocation Channels SCATTERING Small Angle Structural Homology Protein Substrate Specificity Thermus thermophilus

Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source of mutations in diverse cancers, with APOBEC3B...

Cell Line Cyclin-Dependent Kinase Inhibitor p21 Cytidine Deaminase Gene Expression Regulation Neoplastic HCT116 Cells Humans Immunoblotting Minor Histocompatibility Antigens Mutation Neoplasms RNA Interference Reverse Transcriptase Polymerase Chain Reaction Tumor Suppressor Protein p53