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Results: 233
Dynamic structure mediates halophilic adaptation of a DNA polymerase from the deep-sea brines of the Red Sea.
Masateru Takahashi, Etsuko Takahashi, Luay I Joudeh, Monica Marini, Gobind Das, Mohamed M Elshenawy, Anastassja Akal, Kosuke Sakashita, Intikhab Alam, Muhammad Tehseen, Mohamed A Sobhy, Ulrich Stingl, Jasmeen S Merzaban, Enzo Di Fabrizio, Samir M Hamdan
Nov 05, 2018
The deep-sea brines of the Red Sea are remote and unexplored environments characterized by high temperatures, anoxic water, and elevated concentrations of salt and heavy metals. This environment provides a rare system to study...
Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation.
Aslihan Ugun-Klusek, Theodosis S Theodosi, Julia C Fitzgerald, Florence Burté, Christoph Ufer, David J Boocock, Patrick Yu-Wai-Man, Lynn Bedford, E Ellen Billett
Dec 07, 2018
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and...
Autophagy Monoamine Oxidase neurodegeneration Reactive Oxygen Species Autophagy Caspases Cell Line Tumor Cell Survival Fluorescent Antibody Technique Gene Expression Humans Immunohistochemistry Mitochondria Models Biological Monoamine Oxidase Neuroblastoma Oxidation-Reduction Oxidative Stress Phosphorylation Proteome Proteomics Proto-Oncogene Proteins c-bcl-2 Reactive Oxygen Species
Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.
Soni Deshwal, Marleen Forkink, Chou-Hui Hu, Guido Buonincontri, Salvatore Antonucci, Moises Di Sante, Michael P Murphy, Nazareno Paolocci, Daria Mochly-Rosen, Thomas Krieg, Fabio Di Lisa, Nina Kaludercic
May 14, 2018
Monoamine oxidase (MAO) inhibitors ameliorate contractile function in diabetic animals, but the mechanisms remain unknown. Equally elusive is the interplay between the cardiomyocyte alterations induced by hyperglycemia and the...
Animals Cell Degranulation Diabetes mellitus Experimental Endoplasmic reticulum stress Glucose Interleukin-1beta Male Mice Mice Inbred C57BL Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Monoamine Oxidase Monoamine Oxidase Inhibitors Muscle Cells Myocardium RNA Interference RNA Small Interfering Rats Reactive Oxygen Species Ventricular Remodeling
Five-dimensional path integrals for six-dimensional conformal field theories
In this paper we derive Ward-Takahashi identities from the path integral of
supersymmetric five-dimensional field theories with an $SU(1,3)$ spacetime
symmetry in the presence of instantons. We explicitly show how $SU(1,3)$...
Five-Dimensional Path Integrals for Six-Dimensional Conformal Field
Theories
In this paper we derive Ward-Takahashi identities from the path integral of
supersymmetric five-dimensional field theories with an $SU(1,3)$ spacetime
symmetry in the presence of instantons. We explicitly show how $SU(1,3)$...
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.
Andrew J Whittle, Meizi Jiang, Vivian Peirce, Joana Relat, Sam Virtue, Hiroyuki Ebinuma, Isamu Fukamachi, Takashi Yamaguchi, Mao Takahashi, Takeyoshi Murano, Ichiro Tatsuno, Masahiro Takeuchi, Chiaki Nakaseko, Wenlong Jin, Zhehu Jin, Mark Campbell, Wolfgang J Schneider, Antonio Vidal-Puig, Hideaki Bujo
Oct 30, 2015
microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma.
Julja Burchard, Chunsheng Zhang, Angela M Liu, Ronnie TP Poon, Nikki PY Lee, Kwong-Fai Wong, Pak C Sham, Brian Y Lam, Mark D Ferguson, George Tokiwa, Ryan Smith, Brendan Leeson, Rebecca Beard, John R Lamb, Lee Lim, Mao Mao, Hongyue Dai, John M Luk
Aug 08, 2017
Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)-gene interaction network in carcinogenesis, we examined their genome-wide expression profiles in 96 pairs of tumor/non-tumor tissues from...
Animals Carcinoma Hepatocellular Cell Line Tumor Down-Regulation Energy Metabolism Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genes Mitochondrial Humans Liver Liver Neoplasms Mice Mice Inbred C57BL MicroRNAs Mitochondria RNA Messenger Reproducibility of Results Sequence Homology Nucleic Acid Signal Transduction Survival Analysis Up-Regulation
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B
Hannah B L Jones, Rory M Crean, Anna Mullen, Emanuele Kendrick, Steven D Bull, Stephen A Wells, David Ross Carbery, Fraser MacMillan, Marc W van der Kamp, Christopher Roland Pudney
May 07, 2019
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human...
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B
Hannah B L Jones, Rory M Crean, Anna Mullen, Emanuele Kendrick, Steven D Bull, Stephen A Wells, David Ross Carbery, Fraser MacMillan, Marc W van der Kamp, Christopher Roland Pudney
May 07, 2019
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human...
Moving the techno-science gap in Security Force Assistance
David Galbreath
Dec 31, 2019
This paper looks at the impact of military technology diffusion on military assistance operations (MAO), in the United States known as Security Force Assistance or SFA. The discussion looks conceptually at the role of...
Moving the techno-science gap in Security Force Assistance
David Galbreath
Dec 31, 2019
This paper looks at the impact of military technology diffusion on military assistance operations (MAO), in the United States known as Security Force Assistance or SFA. The discussion looks conceptually at the role of...
Capacitive Removal of Heavy Metal Ions from Wastewater via an Electro-Adsorption and Electro-Reaction Coupling Process
Heavy metals widely exist in wastewater, which is a serious threat to human health or water environment. Highly efficient removal of heavy metal ions from wastewater is a major challenge to wastewater treatment. In this work...
Integration of Traditional Cultural Elements Into Civics Teaching Practice in Colleges and Universities Based on Internet Distance Education
Mao Li
Jan 01, 2024
This study uses questionnaire surveys to examine the real impact of incorporating traditional cultural elements into the practice of ideological and political education in colleges and universities. The integration of...
Published by: IGI Global Scientific Publishing
Can You Help Me Stay Fit?
The main purpose of this study is to reveal the impact of consumer satisfaction on continuance intention to use wearable fitness devices. Building upon the IS Continuance Intention Model, the authors explored the effects of...
Published by: IGI Global Scientific Publishing
Validation of a desktop-Type magnet providing a quasi-microgravity space in a room-Temperature bore of a high-gradient trapped field magnet (HG-TFM)
Abstract
The concept of a high-gradient trapped field magnet (HG-TFM), which incorporates a hybrid system of two (RE)BaCuO superconducting bulk components with different functions...
Online Muscle Activation Onset Detection Using Likelihood of Conditional Heteroskedasticity of Electromyography Signals
Surface electromyography (sEMG) signals are crucial in developing human-machine interfaces, as they contain rich information about human neuromuscular activities. <italic>Objective:</italic> The real-time...
Labeling of graphene, graphene oxides, and of their congeners
The area of biomedical imaging is fast becoming an active focus for the utilization of graphene within a variety of imaging modalities. Graphene can be oxidized to produce a material with a high degree of functionality and...
What Makes Consumers Adopt a Wearable Fitness Device?
Wearable fitness devices are equipped with internet connectivity and capable of tracking, storing, and transmitting health data. A research model is proposed and tested, which shows how cognitive, affective, social, and...
Published by: IGI Global Scientific Publishing
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