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The context-specific roles of urea cycle enzymes in tumorigenesis.
The expression of the urea cycle (UC) proteins is dysregulated in multiple cancers, providing metabolic benefits to tumor survival, proliferation, and growth. Here, we review the main changes described in the expression of UC...
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells
Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker
Apr 07, 2021
Tumor cells display metabolic alterations when compared to non-transformed cells. These characteristics are crucial for tumor development, maintenance and survival providing energy supplies and molecular precursors. Anaplerosis...
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells.
Emanuel Gonçalves, Marco Sciacovelli, Ana SH Costa, Maxine Gia Binh Tran, Timothy Isaac Johnson, Daniel Machado, Christian Frezza, Julio Saez-Rodriguez
Feb 13, 2018
Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, the...
Slow waters
GEOFFREY MAGUIRE
Oct 22, 2019
Recent critical approaches to slow queer film in Latin America have focused almost exclusively on the depiction of non-normative sexualities and desires, neglecting both the representational politics of cinematic slowness and...
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.
Petros A Tyrakis, Marie E Yurkovich, Marco Sciacovelli, Evangelia K Papachristou, Hannah R Bridges, Edoardo Gaude, Alexander Schreiner, Clive D'Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R Griffiths, Christian Frezza
May 22, 2018
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial...
Transnational Soldiers and Guerrilla Warfare from the Spanish Civil War to the Second World War
Jorge Marco
Jul 01, 2020
This article analyses how military institutions incorporated innovations in their tactics using the intermediary role of transnational soldiers in the Spanish Civil War. The Soviet experience of guerrilla warfare during the...
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S H Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad Del Socorro Murdoch, Victor H Villar, Raúl V Durán
Sep 11, 2021
Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor...
Cell Line Tumor HCT116 Cells Animals Mice Inbred NOD Mice Knockout Humans Mice SCID Sirolimus Glutamine Adenosine Triphosphate Antineoplastic Agents Xenograft Model Antitumor Assays Signal Transduction Apoptosis Cell Proliferation Male AMP-Activated Protein Kinases HEK293 Cells Mechanistic Target of Rapamycin Complex 1
Published by: Nature Communications
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad Del Socorro Murdoch, Victor H. Villar, Raúl V. Durán
Aug 11, 2021
Abstract: Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the...
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.
Ana Carolina B Sant'Anna-Silva, Juan A Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker
Jun 25, 2021
Tumor cells display metabolic alterations when compared to non-transformed cells. These characteristics are crucial for tumor development, maintenance and survival providing energy supplies and molecular precursors. Anaplerosis...
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana SH Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad Del Socorro Murdoch, Victor H Villar, Raúl V Durán
Oct 11, 2021
AMP-Activated Protein Kinases Adenosine Triphosphate Animals Antineoplastic Agents Apoptosis Cell Line Tumor Cell Proliferation Glutamine HCT116 Cells HEK293 Cells Humans Male Mechanistic Target of Rapamycin Complex 1 Mice Inbred NOD Mice Knockout Mice SCID Signal Transduction Sirolimus Xenograft Model Antitumor Assays
Transnational Soldiers and Guerrilla Warfare from the Spanish Civil War to the Second World War
Jorge Marco
Jul 01, 2020
This article analyses how military institutions incorporated innovations in their tactics using the intermediary role of transnational soldiers in the Spanish Civil War. The Soviet experience of guerrilla warfare during the...
Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma.
Silvano Fasolato, Mariagrazia Ruvoletto, Giorgia Nardo, Andrea Rasola, Marco Sciacovelli, Giacomo Zanus, Cristian Turato, Santina Quarta, Liliana Terrin, Gian Paolo Fadini, Giulio Ceolotto, Maria Guido, Umberto Cillo, Stefano Indraccolo, Paolo Bernardi, Patrizia Pontisso
Apr 24, 2021
Cell proliferation and escape from apoptosis are important pathological features of hepatocellular carcinoma (HCC), one of the tumors with the highest mortality rate worldwide. The aim of the study was to evaluate the expression...
Rethinking the Postwar Period in Spain
Jorge Marco
Jul 31, 2020
There is a consensus among scholars regarding the slow transformation of ‘hot-blooded terror’ into ‘cold-blooded terror’ during the Civil War and the Post-war period in Spain. This article challenges this framework in two ways....
The Antifascist Tower of Babel
Jorge Marco
Dec 01, 2019
The International Brigades were a hybrid bunch: multi-ethnic, multi-national—
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
Rethinking the Postwar Period in Spain
Jorge Marco
Jul 31, 2020
There is a consensus among scholars regarding the slow transformation of ‘hot-blooded terror’ into ‘cold-blooded terror’ during the Civil War and the Post-war period in Spain. This article challenges this framework in two ways....
The Antifascist Tower of Babel
Jorge Marco
Dec 01, 2019
The International Brigades were a hybrid bunch: multi-ethnic, multi-national—
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
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