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Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Mari-Liis Kauts, Bianca De Leo, Carmen Rodríguez-Seoane, Roger Ronn, Fokion Glykofrydis, Antonio Maglitto, Polynikis Kaimakis, Margarita Basi, Helen Taylor, Lesley Forrester, Adam C Wilkinson, Berthold Göttgens, Philippa Saunders, Elaine Dzierzak
Nov 16, 2018
Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently...
ESC GATA2 Venus reporter DIFFERENTIATION iPSC immune effectors innate immune cells Mast Cells rapid protocol Stem Cells Animals Cell Culture Techniques Cell Differentiation Cells Cultured GATA2 Transcription Factor Genes Reporter Humans Mast Cells Mice Mouse embryonic stem cells Peptide Hydrolases Phenotype Pluripotent Stem Cells Receptors Cell Surface
Production and Consumption
Margarita Gleba
Feb 29, 2016
The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells
DNA vaccines promote an immune response by providing antigen-encoding DNA to the recipient, but the efficacy of such vaccines needs improving. Many approaches have considerable potential but currently induce relatively weak...
Published by: Rockefeller University
On the use of the not-at-random fully conditional specification (NARFCS) procedure in practice.
The not-at-random fully conditional specification (NARFCS) procedure provides a flexible means for the imputation of multivariable missing data under missing-not-at-random conditions. Recent work has outlined difficulties with...
Appendix
This is the final version of the book sections (preliminaries plus an appendix). It was first published by University Studio Press.
Attachment representations and socio-emotional difficulties in alternative care
Attachment has been assessed in children living in alternative care (AC) settings, such as Residential Homes (RC) and Foster Care (FC). However, no study has been conducted to compare attachment styles in residential, foster and...
Myosin VI and optineurin are required for polarized EGFR delivery and directed migration.
The polarized trafficking of membrane proteins into the leading edge of the cell is an integral requirement for cell migration. Myosin VI and its interacting protein optineurin have previously been shown to operate in...
Attachment representations and socio-emotional difficulties in alternative care
Attachment has been assessed in children living in alternative care (AC) settings, such as Residential Homes (RC) and Foster Care (FC). However, no study has been conducted to compare attachment styles in residential, foster and...
Dendritic cell targeting of survivin protein in a xenogeneic form elicits strong CD4+ T cell immunity to mouse survivin
To determine whether strong CD4+ T cell immunity could be induced to a nonmutated self protein that is important for tumorigenesis, we selectively targeted the xenogencic form of survivin, a survival protein overexpressed in...
antigen specificity CD4+ T lymphocyte cytokine production memory T lymphocyte dendritic cell T cell depletion
Published by: Rockefeller University
Gdt2 regulates the transition of Dictyostelium cells from growth to differentiation.
Amino Acid Sequence Animals Cell Aggregation Cyclic AMP-Dependent Protein Kinases DNA Protozoan Dictyostelium Folic Acid Gene Expression Regulation Developmental Genes Protozoan Membrane Proteins Molecular Sequence Data Multigene Family Mutation Phenotype Protozoan Proteins Restriction Mapping Sequence Analysis DNA Signal Transduction Starvation
Transcatheter Closure of Patent Ductus Arteriosus in Infants With Weight Under 1,500 Grams.
Persistent patent ductus arteriosus (PDA) is very common in preterm infants, especially in extremely preterm infants. Despite significant advances in management of these vulnerable infants, there has been no consensus on...
Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold.
Anna Suchankova, Margarita Stampelou, Klontiana Koutsouki, Athanasios Pousias, Lakshiv Dhingra, Kerry Barkan, Nicole Pouli, Panagiotis Marakos, Roxane Tenta, Antonios Kolocouris, Nikolaos Lougiakis, Graham Ladds
Jul 17, 2022
Here we describe the design and synthesis of pyrazolo[3,4-d]pyridazines as adenosine receptor (AR) ligands. We demonstrate that the introduction of a 3-phenyl group, together with a 7-benzylamino and 1-methyl group at the...
Stand-Alone Artificial Intelligence for Breast Cancer Detection in Mammography
Alejandro Rodriguez-Ruiz, Kristina Lång, Albert Gubern-Merida, Mireille Broeders, Gisella Gennaro, Paola Clauser, Thomas H Helbich, Margarita Chevalier, Tao Tan, Thomas Mertelmeier, Matthew G Wallis, Ingvar Andersson, Sophia Zackrisson, Ritse M Mann, Ioannis Sechopoulos
Mar 13, 2019
BACKGROUND: Artificial intelligence (AI) systems performing at radiologist-like levels in the evaluation of digital mammography (DM) would improve breast cancer screening accuracy and efficiency. We aimed to compare the...
Promoting Physical Activity Policy
Kate Oldridge-Turner, Margarita Kokkorou, Fiona Sing, Knut-Inge Klepp, Harry Rutter, Arnfinn Helleve, Bryony Sinclair, Louise Meincke, Giota Mitrou, Martin Wiseman, Kate Allen
Apr 30, 2022
Pharmacological characterisation of novel adenosine A3 receptor antagonists.
Kerry Barkan, Panagiotis Lagarias, Margarita Stampelou, Dimitrios Stamatis, Sam Hoare, Dewi Safitri, Karl-Norbert Klotz, Eleni Vrontaki, Antonios Kolocouris, Graham Ladds
Sep 22, 2020
Adenosine A3 Receptor Antagonists Animals Binding Sites Binding Competitive CHO Cells Cricetulus Cyclic AMP Drug Evaluation Preclinical Humans Kinetics Molecular Dynamics Simulation Mutagenesis Site-Directed Radioligand Assay Rats Receptor Adenosine A3 Receptors Purinergic P1 Recombinant Proteins Species Specificity Structure-Activity Relationship
Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial.
Bruno Francois, Simon Lambden, Sebastien Gibot, Marc Derive, Aurelie Olivier, Valerie Cuvier, Stephan Witte, Jean-Marie Grouin, Jean Jacques Garaud, Margarita Salcedo-Magguilli, Mitchell Levy, Pierre-François Laterre
Aug 11, 2021
INTRODUCTION: Septic shock is the subgroup of patients with sepsis, which presents as vasopressor dependence, an elevated blood lactate concentration and is associated with a mortality of at least 30%. Expression of the...
Patterns of Z chromosome divergence among Heliconius species highlight the importance of historical demography.
Steven M Van Belleghem, Margarita Baquero, Riccardo Papa, Camilo Salazar, W Owen McMillan, Brian A Counterman, Chris D Jiggins, Simon H Martin
Jun 12, 2018
Sex chromosomes are disproportionately involved in reproductive isolation and adaptation. In support of such a "large-X" effect, genome scans between recently diverged populations and species pairs often identify distinct...
Quantifying the Interactions in the Aggregation of Thermoresponsive Polymers
Konstantinos Kyriakos, Martine Philipp, Che-Hung Lin, Margarita Dyakonova, Natalya Vishnevetskaya, Isabelle Grillo, Alessio Zaccone, Anna Miasnikova, André Laschewsky, Peter Müller-Buschbaum, Christine M Papadakis
Mar 04, 2016
Promoting Physical Activity Policy
Kate Oldridge-Turner, Margarita Kokkorou, Fiona Sing, Knut-Inge Klepp, Harry Rutter, Arnfinn Helleve, Bryony Sinclair, Louise Meincke, Giota Mitrou, Martin Wiseman, Kate Allen
Apr 30, 2022
Strengthening the integration of eye care into the health system
Stuart Keel, Jennifer R Evans, Sandra Block, Rupert Bourne, Margarita Calonge, Ching-Yu Cheng, David S Friedman, João M Furtado, Rohit C Khanna, Wanjiku Mathenge, Silvio Mariotti, Elenoa Matoto, Andreas Müller, M Mansur Rabiu, Tuwani Rasengane, Jialang Zhao, Richard Wormald, Alarcos Cieza
Aug 11, 2020
Objective: To describe the rational for, and the methods that will be employed to develop, the WHO package of eye care interventions (PECI). Methods and analysis: The development of the package will be conducted in four steps...
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND)
Alys E Bradley, Lyn Miller Wancket, Matthias Rinke, Margarita M Gruebbel, Brett H Saladino, Kenneth Schafer, Osamu Katsuta, Begonya Garcia, Franck Chanut, Katherine Hughes, Keith Nelson, Lauren Himmel, Elizabeth McInnes, Adrienne Schucker, Kazuyuki Uchida
Oct 01, 2021
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain...
Mitigation efforts will not fully alleviate the increase in water scarcity occurrence probability in wheat-producing areas.
Miroslav Trnka, Song Feng, Mikhail A Semenov, Jørgen E Olesen, Kurt Christian Kersebaum, Reimund P Rötter, Daniela Semerádová, Karel Klem, Wei Huang, Margarita Ruiz-Ramos, Petr Hlavinka, Jan Meitner, Jan Balek, Petr Havlík, Ulf Büntgen
Nov 26, 2019
Global warming is expected to increase the frequency and intensity of severe water scarcity (SWS) events, which negatively affect rain-fed crops such as wheat, a key source of calories and protein for humans. Here, we develop a...
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