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Results: 11
Aline Wuidart, Marielle Ousset, Steffen Rulands, Benjamin D Simons, Alexandra Van Keymeulen, Cédric Blanpain
Jun 09, 2016
Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.
Julie K Watson, Steffen Rulands, Adam C Wilkinson, Aline Wuidart, Marielle Ousset, Alexandra Van Keymeulen, Berthold Göttgens, Cédric Blanpain, Benjamin D Simons, Emma L Rawlins
Jun 17, 2015
Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases
Brian Davidson, Kurinchi Gurusamy, Neil Corrigan, Julie Croft, Sharon Ruddock, Alison Pullan, Julia Brown, Maureen Twiddy, Jaqueline Birtwistle, Stephen Morris, Nick Woodward, Steve Bandula, Daniel Hochhauser, Raj Prasad, Steven Olde Damink, Marielle Coolson, K van Laarhoven, Johannes Hw de Wilt
Sep 11, 2020
BACKGROUND: Although surgical resection has been considered the only curative option for colorectal liver metastases, thermal ablation has recently been suggested as an alternative curative treatment. There have been no...
Ablation Techniques Colorectal Neoplasms COST–BENEFIT ANALYSIS Hepatectomy Liver Neoplasm Metastasis randomised controlled trial Adult Colorectal Neoplasms Cost-Benefit Analysis Disease-Free Survival Feasibility Studies Female Humans Liver Neoplasms Male Middle Aged Neoplasm Recurrence Local Netherlands Pilot Projects Prospective Studies Quality of life Risk Factors Treatment Outcome United Kingdom
Green spaces, subjective health and depressed affect in middle-aged and older adults
J Mark Noordzij, Marielle A Beenackers, Joost Oude Groeniger, Erik Timmermans, Basile Chaix, Dany Doiron, Martijn Huisman, Irina Motoc, Milagros Ruiz, Rita Wissa, Mauricio Avendano, Frank J van Lenthe
Jan 29, 2021
BACKGROUND: Studies on associations between urban green space and mental health have yielded mixed results. This study examines associations of green space exposures with subjective health and depressed affect of middle-aged and...
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.
Esther H Lips, Tapsi Kumar, Anargyros Megalios, Lindy L Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A Ahmed, Mingchu Xu, Alexandra W van den Belt-Dusebout, Wim Brugman, Anna K Casasent, Karen Clements, Helen R Davies, Liping Fu, Anita Grigoriadis, Timothy M Hardman, Lorraine M King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C Maley, Jeffrey R Marks, Brian A Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K Schmidt, Abeer M Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk FA Wessels, E Shelley Hwang, Nicholas E Navin, P Andrew Futreal, Grand Challenge PRECISION consortium, Alastair M Thompson, Jelle Wesseling, Elinor J Sawyer
Jul 10, 2022
Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is...
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.
Esther H Lips, Tapsi Kumar, Anargyros Megalios, Lindy L Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A Ahmed, Mingchu Xu, Alexandra W van den Belt-Dusebout, Wim Brugman, Anna K Casasent, Karen Clements, Helen R Davies, Liping Fu, Anita Grigoriadis, Timothy M Hardman, Lorraine M King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C Maley, Jeffrey R Marks, Brian A Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K Schmidt, Abeer M Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk FA Wessels, E Shelley Hwang, Nicholas E Navin, P Andrew Futreal, Grand Challenge PRECISION consortium, Alastair M Thompson, Jelle Wesseling, Elinor J Sawyer
Jun 14, 2022
Screening for ovarian cancer in women with varying levels of risk, using annual tests, results in high recall for repeat screening tests.
Marielle Ae Nobbenhuis, Elizabeth Bancroft, Eleanor Moskovic, Fiona Lennard, Paul Pharoah, Ian Jacobs, Ann Ward, Desmond Pj Barton, Thomas Ej Ind, John H Shepherd, Jane E Bridges, Martin Gore, Chris Haracopos, Susan Shanley, Audrey Ardern-Jones, Sarah Thomas, Ros Eeles
Dec 06, 2011
Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.
Joseph J Caumanns, Katrien Berns, G Bea A Wisman, Rudolf SN Fehrmann, Tushar Tomar, Harry Klip, Gert J Meersma, E Marielle Hijmans, Annemiek MC Gennissen, Evelien W Duiker, Desiree Weening, Hiroaki Itamochi, Roelof JC Kluin, Anna KL Reyners, Michael J Birrer, Helga B Salvesen, Ignace Vergote, Els Van Nieuwenhuysen, James Brenton, E Ioana Braicu, Jolanta Kupryjanczyk, Beata Spiewankiewicz, Lorenza Mittempergher, René Bernards, Ate GJ van der Zee, Steven de Jong
Sep 10, 2018
Purpose: Advanced-stage ovarian clear cell carcinoma (OCCC) is unresponsive to conventional platinum-based chemotherapy. Frequent alterations in OCCC include deleterious mutations in the tumor suppressor ARID1A and activating...
Adenocarcinoma Clear Cell Animals Cell Line Tumor Cell Proliferation Class I Phosphatidylinositol 3-Kinases DNA-Binding Proteins Female Gene Expression Regulation Neoplastic Heterografts Humans Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Mice Morpholines Mutation Nuclear Proteins Ovarian Neoplasms Signal Transduction Transcription Factors
Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects.
Anna R Duncan, Antonio Vitobello, Stephan C Collins, Valerie E Vancollie, Christopher J Lelliott, Lance Rodan, Jiahai Shi, Ann R Seman, Emanuele Agolini, Antonio Novelli, Paolo Prontera, Maria J Guillen Sacoto, Teresa Santiago-Sim, Aurélien Trimouille, Cyril Goizet, Mathilde Nizon, Ange-Line Bruel, Christophe Philippe, Patricia E Grant, Monica H Wojcik, Joan Stoler, Casie A Genetti, Marieke F van Dooren, Saskia M Maas, Marielle Alders, Laurence Faivre, Arthur Sorlin, Grace Yoon, Binnaz Yalcin, Pankaj B Agrawal
Feb 10, 2021
KDM4B is a lysine-specific demethylase with a preferential activity on H3K9 tri/di-methylation (H3K9me3/2)-modified histones. H3K9 tri/di-demethylation is an important epigenetic mechanism responsible for silencing of gene...
JMJD2B KDM4B Agenesis of the corpus callosum dysmorphic hippocampi global developmental delay heterozygous variant Intellectual Disability neurodevelopmental disorder Animals Brain Developmental Disabilities Epigenesis Genetic Female genetic variation Heterozygote Hippocampus Histones Humans Jumonji Domain-Containing Histone Demethylases Magnetic Resonance Imaging Male Methylation Mice Nervous System Malformations Protein Processing Post-Translational Seizures Signal Transduction
Immuno-transcriptomic profiling of extracranial pediatric solid malignancies.
Andrew S Brohl, Sivasish Sindiri, Jun S Wei, David Milewski, Hsien-Chao Chou, Young K Song, Xinyu Wen, Jeetendra Kumar, Hue V Reardon, Uma S Mudunuri, Jack R Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J Zhu, Katherine E Masih, Marielle E Yohe, Jack F Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J Orentas, Igor B Kuznetsov, Nicolas J Llosa, John A Ligon, Brian K Turpin, Daniel G Leino, Shintaro Iwata, Irene L Andrulis, Jay S Wunder, Silvia RC Toledo, Paul S Meltzer, Ching Lau, Beverly A Teicher, Heather Magnan, Marc Ladanyi, Javed Khan
Jan 07, 2022
We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657 pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally utilize transcriptomes of 131 pediatric cancer cell...
PRAME RNA sequencing T cell receptor adoptive cell therapy immunogenomics immunopeptidomics Pediatric oncology tumor-infiltrating lymphocytes Adolescent Antigens Neoplasm Cell Line Tumor Child Child Preschool Female Gene Expression Gene Expression Profiling Humans Immune Checkpoint Proteins immunogenetics Immunotherapy Adoptive Infant Lymphocytes Tumor-Infiltrating Male Neoplasms Receptors Antigen T-Cell Transcriptome Tumor Microenvironment Exome Sequencing
Pf7
Muzamil Mahdi Abdel Hamid, Mohamed Hassan Abdelraheem, Desmond Omane Acheampong, Ambroise Ahouidi, Mozam Ali, Jacob Almagro-Garcia, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Ben Andagalu, Tim Anderson, Voahangy Andrianaranjaka, Ifeyinwa Aniebo, Enoch Aninagyei, Felix Ansah, Patrick O Ansah, Tobias Apinjoh, Paulo Arnaldo, Elizabeth Ashley, Sarah Auburn, Gordon A Awandare, Hampate Ba, Vito Baraka, Alyssa Barry, Philip Bejon, Gwladys I Bertin, Maciej F Boni, Steffen Borrmann, Teun Bousema, Marielle Bouyou-Akotet, Oralee Branch, Peter C Bull, Huch Cheah, Keobouphaphone Chindavongsa, Thanat Chookajorn, Kesinee Chotivanich, Antoine Claessens, David J Conway, Vladimir Corredor, Erin Courtier, Alister Craig, Umberto D'Alessandro, Souleymane Dama, Nicholas Day, Brigitte Denis, Mehul Dhorda, Mahamadou Diakite, Abdoulaye Djimde, Christiane Dolecek, Arjen Dondorp, Seydou Doumbia, Chris Drakeley, Eleanor Drury, Patrick Duffy, Diego F Echeverry, Thomas G Egwang, Sonia Maria Mauricio Enosse, Berhanu Erko, Rick M Fairhurst, Abdul Faiz, Caterina A Fanello, Mark Fleharty, Matthew Forbes, Mark Fukuda, Dionicia Gamboa, Anita Ghansah, Lemu Golassa, Sonia Goncalves, G L Abby Harrison, Sara Anne Healy, Jason A Hendry, Anastasia Hernandez-Koutoucheva, Tran Tinh Hien, Catherine A Hill, Francis Hombhanje, Amanda Hott, Ye Htut, Mazza Hussein, Mallika Imwong, Deus Ishengoma, Scott A Jackson, Chris G Jacob, Julia Jeans, Kimberly J Johnson, Claire Kamaliddin, Edwin Kamau, Jon Keatley, Theerarat Kochakarn, Drissa S Konate, Abibatou Konaté, Aminatou Kone, Dominic P Kwiatkowski, Myat P Kyaw, Dennis Kyle, Mara Lawniczak, Samuel K Lee, Martha Lemnge, Pharath Lim, Chanthap Lon, Kovana M Loua, Celine I Mandara, Jutta Marfurt, Kevin Marsh, Richard James Maude, Mayfong Mayxay, Oumou Maïga-Ascofaré, Olivo Miotto, Toshihiro Mita, Victor Mobegi, Abdelrahim Osman Mohamed, Olugbenga A Mokuolu, Jaqui Montgomery, Collins Misita Morang'a, Ivo Mueller, Kathryn Murie, Paul N Newton, Thang Ngo Duc, Thuy Nguyen, Thuy-Nhien Nguyen, Tuyen Nguyen Thi Kim, Hong Nguyen Van, Harald Noedl, Francois Nosten, Rintis Noviyanti, Vincent Ntui-Njock Ntui, Alexis Nzila, Lynette Isabella Ochola-Oyier, Harold Ocholla, Abraham Oduro, Irene Omedo, Marie A Onyamboko, Jean-Bosco Ouedraogo, Kolapo Oyebola, Wellington Aghoghovwia Oyibo, Richard Pearson, Norbert Peshu, Aung P Phyo, Christopher V Plowe, Ric N Price, Sasithon Pukrittayakamee, Huynh Hong Quang, Milijaona Randrianarivelojosia, Julian C Rayner, Pascal Ringwald, Anna Rosanas-Urgell, Eduard Rovira-Vallbona, Valentin Ruano-Rubio, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Victoria J Simpson, Mahamadou S Sissoko, Christen Smith, Xin-Zhuan Su, Colin Sutherland, Shannon Takala-Harrison, Arthur Talman, Livingstone Tavul, Ngo Viet Thanh, Vandana Thathy, Aung Myint Thu, Mahamoudou Toure, Antoinette Tshefu, Federica Verra, Joseph Vinetz, Thomas E Wellems, Jason Wendler, Nicholas J White, Georgia Whitton, William Yavo, Rob W van der Pluijm
Apr 02, 2023
We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries...
Published by: Wellcome open research